CTSI Core Assay Laboratory

The Boston University Clinical and Translational Science (BU CTSI) Institute integrates, connects, and expands research and programs across traditional academic departments and schools. The institute acts as a bridge between disciplines to facilitate interactions by incorporating multiple key programs that support the university-wide commitment to a home for translational research. An NIH-funded clinical and translational science award funds the Institute to build on existing strengths to create an environment linking faculty members, trainees and university programs. The ultimate goal is to speed the translation of innovations in medical science in order to improve maintenance of health and diagnosis and treatment of diseases and share these innovations with other University-based Clinical and Translational Science Awards (CTSAs). The BU CTSI environment also supports the bi-directional development and translation of ideas that begin in the clinic to the BU scientific community and back to identify new ways to improve health and delivery of health care services. Moreover, the Institute significantly enhances existing partnerships with Boston’s community health centers, transforming the conduct of clinical and translational research by infusing it with community-based perspectives and needs.

The CTSI Core Assay Laboratory has acquired an Agilent High Performance Liquid Chromatography System Model 1200.

The instrument is equipped with: (1)  Quaternary Pump with Degasser, (2)  Autosampler, (3) Thermostat for ALS/FC/Spotter, (4) Thermostatted Column Compartment, (5) Column Switching device, and (6) Diode Array UV/Visible Detector which includes RFID tracking technology for flow cells and UV lamp. Its primary application is for the isolation, identification and quantification of large and small molecular weight compounds which can absorb light between 190 and 950 nm.

Introduction to the General Clinical Research Unit (GCRU)

The BUMC General Clinical Research Unit supports research services, specialized laboratories and a clinical research-training program for all BU staff including investigators in Medicine, Surgery, Psychiatry, Behavioral Sciences, Dentistry and Public Health.

The facility provides investigators in medicine and dentistry with the nfollowing: the ability to conduct pharmacokinetic studies in a controlled environment in both adult and pediatric inpatients and outpatients the resources for timed collection of specimens and repetitive tests (e.g. polysomnography, stress tests, bone density, etc.) the expertise to conduct esoteric laboratory testing a bioinformatics core with professionals to assist with statistical design, data management and analysis a private environment to explore patterns of behavior the location for education of future physicians, scientists and nutritionists in patient oriented research.

The Core Assay Laboratory is a part of the  General Clinical Research Unit and is accessed through an application to the GCRU.

See General Clinical Research Unit under Investigators. The assays performed are part of a clinical research protocol that is approved by the IRB and the Clinical Research Resources Advisory Committee (CRRAC).

Current assays include but are not limited to:

  1. 25(OH)D
  2. PTH
  3. Osteocalcin
  4. CTX
  5. CRP
  6. TSH
  7. Insulin
  8. Cortisol
  1. Glucagon
  2. Leptin
  3. TNF_alpha
  4. C-peptide
  5. Testosterone (total)
  6. Estradiol
  7. DHT
  8. SHBG
  1. LH
  2. FSH
  3. PSA
  4. Fat tissue D2 and D3
  5. Fat tissue 25D2 and 25D3
  6. Serum D2 and D#
  7. Serum 25D2 and D3
  8. 1,25(OH)2D

    Investigators are often, but not always, asked to cost share through the purchase of assay kits.  For detailed information contact us:

    Tai Chen, PhD, Director
    Phone: 617 -638-4543
    Fax: 617-638-8898

    Fuller Building, M-1022
    85 East Newton St, 10th Floor
    Boston, MA 02118

    Monday – Friday
    9:00 AM to 5:00 PM