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| About Boston |
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| Agenda |
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| Genomics Workshop |
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CRYPTOCOCCUS
& CRYPTOCOCCOSIS |
Scientific
Program
| Friday, June 24, 2005 | ||
| 1:00pm | W1. Genomics Workshop | |
| 6:30pm | Opening Address:
"The Uniqueness of Cryptococcus neoformans" Arturo Casadevall, Albert Einstein College of Medicine, Bronx, NY, USA |
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| SOCIAL EVENT: Welcome Reception | ||
| <top> | ||
| Saturday, June 25, 2005 | ||
| 8:10am | Announcements | |
| S1.
Virulence Conveners: John Perfect and Jennifer Lodge |
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| 8:15am | S1.1. | Cryptococcus
neoformans: The Yeast That Likes It Hot!!!!! John Perfect, Duke University, Durham, NC, USA |
| 8:40am | S1.2. | Mechanisms of
Resistance to Oxidative and Nitrosative Stress Jennifer Lodge, St. Louis University, St. Louis, MO, USA |
| 9:05am | S1.3. | Phenotypic Switching
in Cryptococcus neoformans: Implications for Pathogenesis Bettina Fries, Albert Einstein College of Medicine, Bronx, NY, USA |
| 9:30am | S1.1.Oral: | A Calcium-Selective
Voltage-Gated Channel in the Plasma Membrane of Cryptococcus neoformans Presenter: Angie Gelli |
| 9:45am | S1.2.Oral: | Mass Spectrometry
Reveals Novel Structural Elements in Glucuronoxylomannan that Imply
the Potential for Enormous Antigenetic Variation Presenter: Diane C. McFadden |
| 10:00am | Coffee Break | |
| S2.
Insights from Clinical Studies Conveners: Jack Bennett and Peter Pappas |
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| 10:30am | S2.1. | Immune Reconstitution
Inflammatory Syndrome During AIDS-associated Cryptococcosis Olivier Lortholary, Institut Pasteur, Paris, France |
| 10:55am | S2.2. | Quantitative
Cultures for Assessment of the Fungicidal Activity of Novel Regimens Thomas Harrison, St. George's Hospital, London, England |
| 11:20am | S2.3. | Cryptococcosis
in Transplant Recipients Peter Pappas, University of Alabama School of Medicine, Birmingham, AL, USA |
| 11:45am | S2.1.Oral: | Genotyping
by Multilocus Sequence Typing Reveals Three Genetically Distinct Subpopulations
of Cryptococcus neoformans var. grubii (serotype A),
Including a Unique, Possibly Recombining, Population in Botswana Presenter: Anastasia P. Litvintseva |
| 12:00pm | Lunch Break | |
| S3.Capsule Conveners: Tamara Doering and Thomas Kozel |
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| 1:50pm | S3.1. | Capsule Biosynthesis Guihem Janbon, Institut Pasteur, Paris, France |
| 2:15pm | S3.2. | The Ins and
Outs of Capsule Synthesis Tamara Doering, Washington University, St. Louis, MO, USA |
| 2:40pm | S3.3. | Capsule, Complement
and Antibody Interactions Thomas Kozel, University of Nevada, Reno, NV, USA |
| 3:05pm | S3.4. | GXM as an Immunosuppressive
Agent Anna Vecchiarelli, University of Perugia, Perugia, Italy |
| 3:30pm | Coffee Break | |
| S4.
Sex, Signaling, and the Mating Type Locus Conveners: June Kwon-Chung and Joseph Heitman |
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| 4:00pm | S4.1. | Sex, MAT, and
Virulence of Cryptococcus neoformans Joseph Heitman, Duke University, Durham, NC, USA |
| 4:25pm | S4.2. | Biology of the
Mating System on Cryptococcus Virulence: Is MATa Functionally
the Male, While MATa is a Female? June Kwon-Chung, National Institutes of Health, Bethesda, MD, USA |
| 4:50pm | S4.3. | Regulators of
G-Protein Signaling in Cryptococcal Virulence Ping Wang, Children's Hospital, New Orleans, LA, USA |
| 5:15pm | S4.4. | G-Protein Signaling
in Cryptococcal Virulence Andrew Alspaugh, Duke University, Durham, NC, USA |
| 5:40pm | S4.1.Oral: | Sexual Reproduction
Between Partners of the Same Mating-Type in Cryptococcus neoformans Presenter: Xiaorong Lin |
| 5:55pm | Adjourn | |
| <top> | ||
| Sunday, June 26, 2005 | ||
| 8:10am | Announcements | |
| S5.
Pathogenesis This session is sponsored by the Ellison Medical Foundation. Conveners: Frank Coenjaerts and Maurizio del Poeta |
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| 8:10am | S5.1. | Novel Aspects
in Cryptococcal Pathogenesis Frank Coenjaerts, University Medical Centre Utrecht, Utrecht, The Netherlands |
| 8:40am | S5.2. | Interacting
Regulators of Fungal Virulence Peter Williamson, University of Illinois - Chicago, Chicago, IL, USA |
| 9:05am | S5.3. | Sphingolipid-Mediated
Host-Pathogen Interaction: The Role of Ceramides Maurizio del Poeta, Medical University of South Carolina, Charleston, SC, USA |
| 9:30am | S5.1.Oral: | Secretion of
Cryptococcal Phospholipase B1 (PLB1) is regulated by a Glycosylphosphatidylinositol
(GPI) Anchor Presenter: Julianne T. Djordjevic |
| 9:45am | S5.2.Oral: | CD63 is Selectively
Recruited to Phagosomes Containing Cryptococcus neoformans
in Primary Mouse Bone Marrow Dendritic Cells Presenter: Jatin M. Vyas |
| 10:00am | Coffee Break | |
| S6.
Cryptococcus neoformans: One, Two, or More Species Convener: Ira Salkin |
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| 10:30am | S6.1. | Molecular Characterization
of the Cryptococcus neoformans Species Complex Wieland Meyer, University of Sydney, Sydney, Australia |
| 10:55am | S6.2. | Is it a One,
Two, or More Species System Supported by the Major Species Concept? June Kwon-Chung, National Institutes of Health, Bethesda, MD, USA |
| 11:10am | S6.3. | How Many Species? Teun Boekhout, Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands |
| 11:25am | S6.4. | Debate: How
Many Species and Varietal States Are There? June Kwon-Chung, National Institutes of Health, Bethesda, MD, USA Teun Boekhout, Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands Wieland Meyer, University of Sydney, Sydney, Australia |
| 12:15pm | Lunch Break | |
| S7.
Model Systems from Worms to Rodents to Humans Conveners: Arturo Casadevall and Thomas Harrison |
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| 2:00pm | S7.1. | Cryptococcus
neoformans and Asthma David Goldman, Albert Einstein College of Medicine, Bronx, NY, USA |
| 2:25pm | S7.2. | Worms, Flies,
and the Pursuit of Cryptococcal Pathogenesis: Heterologous Hosts and
the Study of Cryptococcal Host/Pathogen Interactions Eleftherios Mylonakis, Massachusetts General Hospital, Boston, MA, USA |
| 2:50pm | S7.3. | Mechanisms of
Direct Lymphocyte-Mediated Anticryptococcal Activity Christopher Mody, University of Calgary, Calgary, Canada |
| 3:15pm | S7.1.Oral: | Protection Against
Cryptococcosis Using a Cytokine Secreting Cryptococcus neoformans
Strain Presenter: Floyd L. Wormley, Jr. |
| 3:30pm | S8. Poster Session 1 | |
| 5:30pm | Adjourn | |
| SOCIAL EVENT: Harbor Cruise | ||
| <top> | ||
| Monday, June 27, 2005 | ||
| 8:10am | Announcements | |
| S9.
The Road from the Lung to the Brain Conveners: Tania Sorrell and Françoise Dromer |
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| 8:15am | S9.1. | Lung Adherent
Cells - Their Responses During Pulmonary Cryptococcosis Juneann Murphy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| 8:40am | S9.2. | How Do Cryptococcal
Cells Invade the Central Nervous System? Yun Chang, National Institutes of Health, Bethesda, MD, USA |
| 9:05am | S9.3. | What NMR Spectroscopy
Has Revealed About Cryptococcus and Cryptococcosis Tania Sorrell, University of Sydney, Sydney, Australia |
| 9:30am | S9.4. | Cryptococcus
neoformans Crossing of the Blood Brain Barrier Françoise Dromer, Institut Pasteur, Paris, France |
| 9:55am | Coffee Break | |
| S10.
Innate and Acquired Host Immune Responses Conveners: Kazuyoshi Kawakami and Juneann Murphy |
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| 10:25am | S10.1. | The Dynamics
of Cell-Mediated Immunity to Cryptococcus Gary Huffnagle, University of Michigan, Ann Arbor, MI, USA |
| 10:50am | S10.2. | DC-Based Host
Protection from Lethal Infection with Cryptococcus neoformans Kazuyoshi Kawakami, University of the Ryukyus, Okinawa, Japan |
| 11:15am | S10.3. | Immunoprotective
Cryptococcal Proteins Giuseppe Teti, Universita di Messina, Messina, Italy |
| 11:40am | S10.4. | How Dendritic
Cells Recognize Mannoproteins to Initiate a Cell-Mediated Immune Response Stuart Levitz, Boston University, Boston, MA, USA |
| 12:05pm | Luncheon
Session: Optimizing Antifungal Therapy Convener: Marianna Viviani Supported by an unrestricted educational grant from ENZON Pharmaceuticals, Inc. |
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| 1. | How Will Prospective
Databases Help Us Manage Our Patients with Cryptococcosis and Other
Mycoses? John Perfect, Duke University, Durham, NC, USA |
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| 2. | Antifungal Susceptibility
Testing Mahmoud Ghannoum, Case Western Reserve University, Cleveland, OH, USA |
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| 2:00pm | S11. Poster Session 2 | |
| S12.
Genomics: Proteomics and Glycomics Conveners: Jim Kronstad and Fred Dietrich |
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| 3:50pm | S12.1. | Transcriptional
Analysis of Cryptococcus neoformans by Arbitrary-Primed PCR Brian Wickes, University of Texas Health Sciences Center, San Antonio, TX, USA |
| 4:15pm | S12.2. | Exploring the
Serotype A Genome Fred Dietrich, Duke University, Durham, NC, USA |
| 4:40pm | S12.3. | Characterization
of Iron-Regulated Genes That Encode Sensing and Uptake Functions Jim Kronstad, University of British Columbia, Vancouver, Canada |
| 5:05pm | S12.4. | Chitin and Chitosan
Synthesis for the Cryptococcal Cell Wall Charles Specht, Boston University, Boston, MA, USA |
| 5:30pm | Adjourn | |
| 6:00pm | SOCIAL EVENT: Closing Banquet | |
| <top> | ||
| Tuesday, June 28, 2005 | ||
| 8:10am | Announcements | |
| S13.
Ecology and Epidemiology Conveners: David Ellis and Shigeru Khono |
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| 8:15am | S13.1. | Canadian Cryptococcus
gattii - Temporary Visa or Landed Immigrant? Karen Bartlett, University of British Columbia, Vancouver, Canada |
| 8:40am | S13.2. | The Contribution
of Veterinary Medicine to Understanding the Global Epidemiology of
Cryptococcosis Richard Malik, University of Sydney, Sydney, Australia |
| 9:05am | S13.3. | Sex and the
Natural Ecology of Cryptococcus: How Can We Prove It and Why Do We
Want To Know? Dee Carter, University of Sydney, Sydney, Australia |
| 9:30am | S13.1.Oral: | Direct and Indirect
Analysis Identifies Recombination and Mating in Australian Cryptococcus
gattii Isolates Presenter: Leona Campbell |
| 9:45am | S13.2.Oral: | Gene Genealogies
Indicate Multiple Recent Migrations and a Clonal Propagation of at
Least Two Distinct Evolutionary Lineages of Cryptococcus gattii
Isolates in British Columbia Presenter: S.E. Kidd |
| 10:00am | Coffee Break | |
| S14.
New Agents and Therapeutic Approaches Conveners: Marianne Viviani and Itzhack Polacheck |
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| 10:30am | S14.1. | Variety in
Cryptococcal Pathogenesis Shigeru Kohno, Nagasaki University, Nagasaki, Japan |
| 10:55am | S14.2. | Opportunities
for Research and Treatment of Cryptococcosis in Tanzania Gary Cox, Duke University, Durham, NC, USA |
| 11:20am | S14.3. | Towards a Vaccine
for Cryptococcus neoformans Liise-anne Pirofski, Albert Einstein College of Medicine, Bronx, NY, USA |
| 11:45am | S14.1.Oral: | Radiobiological
and Immune Mechanisms of Radioimmunotherapy of Cryptococcus neoformans
Infection Presenter: E. Dadachova |
| 12:00pm | Adjourn | |
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