Publications

(95) Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. Tardiff, D. F.; Brown, L. E.; Yan, X.; Trilles, R.; Jui, N. T.; Barrasa, M. I.; Caldwell, K. A.; Caldwell, G. A.; Schaus, S. E.; Lindquist, S. ACS Chem. Neurosci. 2017, DOI: 10.1021/acschemneuro.7b00187

(94) A Photochemical Flow Reactor for Large Scale Syntheses of Aglain and Rocaglate Natural Product Analogues. Yueh, H.; Gao, Q., Porco, J. A., Jr.; Beeler, A. B. Bioorg. Med. Chem. 2017, DOI: 10.1016/j.bmc.2017.06.010

(93)  Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Manier, S.;Huynh,D.; Shen, Y. J.; Zhou, J.; Yusufzai, T.; Salem, K. Z.; Ebright, R. Y.; Shi, J.; Park, J.; Glavey, S. V.; Devine, W. G.; Liu, C.-J.; Leleu, X.; Quesnel, B.; Roche-Lestienne, C.; Snyder, J. K.; Brown, L. E.; Gray, N.; Bradner, J.; Whitesell, L.; Porco, J. A. Jr.; Ghobrial,I. M. Sci. Transl. Med., 2017, 9, eaal2668. DOI: 10.1126/scitranslmed.aal2668

(92) Development of a Potent and Selective HDAC8 Inhibitor. Ingham, O. J.; Paranal, R. M.; Smith, W. B.; Escobar, R. A.; Yueh, H.; Snyder, T.; Porco, J. A., Jr.; Bradner, J. E.; Beeler, A. B. ACS Med. Chem. Lett. 2016, 7, 929-932. DOI: 10.1021/acsmedchemlett.6b00239

(91) Asymmetric Dearomatization/Cyclization Enables Access to Novel Chemotypes. Hayashi, M.; Brown, L. E.; Porco, J. A., Jr. Eur. J. Org. Chem. 201628, 4800-4804. DOI: 10.1002/ejoc.201601003

(90) Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Bhattacharya, B.; Chatterjee, S; Devine, W.G.; Kobzik, L.; Beeler, A.B.; Porco, J.A., Jr.; Kramnik, I. Sci. Rep. 20166, 24409. DOI: 10.1038/srep24409

(89) A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Liu, S.; Wang, W.; Brown, L. E.; Qiu, C.; Lajkiewicz, N.; Zhao, T.; Zhou, J.; Porco, J. A., Jr.; Wang, T. T. EBioMedicine, 2015, 2, 1600-1606. DOI: 10.1016/j.ebiom.2015.09.018

(88) Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Yeo, A. T.; Chennamadhavuni, S.; Whitty, A.; Porco, J. A., Jr.; Gilmore, T. D. Molecules, 2015, 20, 7474-7494. DOI: 10.3390/molecules20057474

(87) Rapid Synthesis of Polyprenylated Acylphoroglucinol Analogs via Dearomative Conjunctive Allylic Annulation. Grenning, A. J.; Boyce, J. H.; Porco, J. A., Jr. J. Am. Chem. Soc., 2014, 136, 11799-11804. DOI: 10.1021/ja5060302

(86) How proteins bind macrocycles. Villar, E. A.; Beglov, D.; Chennamadhavuni, S.; Porco, J. A., Jr.; Kozakov, D.; Vajda, S.; Whitty, A. Nat. Chem. Bio., 2014, 10, 723-731. DOI: 10.1021/nchembio.1584

(85) Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes. Martin, V. I.; Goodell, J. R.; Ingham, O. J.; Porco, J. A., Jr.; Beeler, A. B. J. Org. Chem., 2014, 79, 3838-3846. DOI: 10.1021/jo500190b

(84) Total Syntheses of Secalonic Acids A and D. Qin, T.; Porco, J. A., Jr. Angew. Chemie Int. Ed., 2014, 53, 3107-3110. DOI: 10.1002/anie.201311260

(83) Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction. Grenning, A. J.; Snyder, J. K.; Porco, J. A., Jr. Org. Lett., 2014, 16, 792-795. DOI: 10.1021/ol4035269

(82) Rhodium(II)-Catalyzed Alkyne Amination of Homopropargylic Sulfamate Esters: Stereoselective Synthesis of Functionalized Norcaradienes by Arene Cyclopropanation. Brawn, R. A.; Zhu, K.; Panek, J. S. Org. Lett., 2014, 16, 74-77. DOI: 10.1021/ol403035g

(81) Tandem Dienone Photorearrangement-Cycloaddition for the Rapid Generation of Molecular Complexity. Bos, P. H.; Antalek, M. T.; Porco, J. A.; Stephenson, C. R. J. J. Am. Chem. Soc., 2013, 135, 17978-17982. DOI: 10.1021/ja409992m

(80) Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.. Filone C. M.; Hodges E. N.; Honeyman B.; Bushkin G. G.; Boyd K.; Platt A.; Ni F.; Strom K.; Hensley L.; Snyder J. K.; Connor J. H. Chem. Biol., 2013, 20, 424-433. DOI: 10.1016/j.chembiol.2013.02.011

(79) Metal-Catalyzed Cascade Rearrangements of 3-Alkynyl Flavone Ethers. Xiong, Y.; Schaus, S. E.; Porco, J. A. Jr., Org. Lett., 2013, 15, 1962-1965. DOI: 10.1021/ol400631b

(78) Enantioselective Addition of Boronates to o-Quinone Methides Catalyzed by Chiral Biphenols. Luan, Y.; Schaus, S.E.
J. Am. Chem. Soc., 2012, 134, 19965-19968. DOI: 10.1021/ja309076g

(77) Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne-Alkene Reductive Coupling and Annulation Sequence. Wu, J.; Pu, Y.; Panek, J. S. J. Am. Chem. Soc., 2012, 134, 18440-18446. DOI: 10.1021/ja3083945

(76) Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation. Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A. Jr. J. Am. Chem. Soc., 2012, 134, 19782-19787. DOI: 10.1021/ja3084708

(75) Bifunctional homoallylic carbamates from chiral silane additions to in situ generated N-acyl iminium ions. Wu, J.; Zhu, K.-C.; Yuan, P.-W.; Panek, J. S. Org. Lett., 2012, 14, 3624-3627. DOI: 10.1021/ol301428y

(74) An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Ma, Z.; Ni, F.; Woo, G.H.C.; Lo, S.-M.; Roveto, P.M.; Schaus, S. E.; Snyder, J.K. Beilstein J. Org. Chem., 2012, 8, 829-840. DOI: 10.3762/bjoc.8.93
[ Link to Publication ]

(73) Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Leng, B.; Chichetti, S.; Su, S.; Beeler, A. B.; Porco, J. A., Jr.; Beilstein J. Org. Chem., 2012, 8, 1338-1343. DOI: 10.3762/bjoc.8.153
[ Link to Publication ]

(72) Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Dower, K.; Filone, C. M.; Hodges, E. N.; Bjornson, Z. B.; Rubins, K. H.; Brown, L. E.; Schaus, S.; Hensley, L. E.; Connor, J. H. J.Virol., 2012, 86, 2632-2640. DOI: 10.1128/JVI.05416-11
[ Link to Publication ]

(71) Direct Binding of a Hepatitis C Virus Inhibitor to the Viral Capsid Protein. Kota, S.; Takahashi, V.; Ni, F.; Snyder, J. K.; Strosberg, A. D. PLoS ONE, 2012, 7, e32207. DOI: 10.1371/journal.pone.0032207
[ Link to Publication ]

(70) Synthesis of Azaphilone-Based Chemical Libraries. Achard, M.; Beeler, A. B.; Porco, J. A., Jr. ACS Comb. Sci., 2012, 14, 236-244. DOI:10.1021/co300002x
[ Link to Publication ]

(69) Development of a Photochemical Microfluidics Platform. Pimparkar, K.; Yen, B.; Goodell, J. R.; Martin, V. I.; Lee, W.-H.; Porco, J. A., Jr., Beeler, A. B.; Jensen, K. F. Journal of Flow Chemistry, 2011, 1, 53-55. DOI: 10.1556/jfchem.2011.00006
[ Link to Publication ]

(68) Iron-Catalyzed Rearrangements and Cycloaddition Reactions of 2H-Chromenes. Luan, Y.; Sun, H.; Schaus, S. E. Org. Lett., 2011, 13, 6480-6483. DOI: 10.1021/ol202772k
[ Link to Publication ]

(67) Remodelling of the Natural Product Fumagillol Employing a Reaction Discovery Approach. Balthaser, B. R.; Maloney, M. C.; Beeler, A. B.; Porco, J. A., Jr; Snyder J. K. Nature Chemistry, 2011, 3, 969-973. DOI: 10.1038/nchem.1178
[ Link to Publication ]

(66) Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes. Goodell, J. R.; Poole, J. L.; Beeler, A. B.; Aube, J.; Porco, J. A. Jr. J. Org. Chem., 2011, 76, 9792-9800. DOI: 10.1021/jo2018922
[ Link to Publication ]

(65) Microwave-Based Reaction Screening: Tandem Retro-Diels-Alder/Diels-Alder Cycloadditions of o-Quinol Dimers. Dong, S.; Cahill, K. J.; Kang, M.-I.; Colburn, N. H.; Henrich, C. J.; Wilson, J. A.; Beutler, J. A.; Johnson, R. P.; Porco, J. A., Jr. J. Org. Chem., 2011, 76, 8944-8954. DOI: 10.1021/jo201658y
[ Link to Publication ]

(64) Tandem Visible Light-Mediated Radical Cyclization-Divinylcyclopropane Rearrangement to Tricyclic Pyrrolidinones. Tucker, J. W.; Stephenson, C. R. J. Org. Lett., 2011, 13, 5468-5471. DOI: 10.1021/ol202178t

(63) Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds. Gibeau, A. L.; Snyder, J. K. Heterocycles, 2011, 84, 135-155. DOI: 10.3987/REV-11-SR(P)4

(62) Indium(III)-Catalyzed Hydrative Cyclization of 1,7-Diynyl Ethers. Gibeau, A. L.; Snyder, J. K. Org. Lett., 2011, 13, 4280-4283. DOI: 10.1021/ol201624b

(61) Gold Catalyzed Cyclization of Alkyne-Tethered Dihydropyrimidones. Brown, L. E.; Dai, P.; Porco, J. A., Jr.; Schaus, S. E. Org. Lett., 2011, 13, 4228-4231. DOI: 10.1021/ol2015658

(60) A Cycloisomerization/Friedel-Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles. Medeiros, M. R.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett., 2011, 13, 4012-4015. DOI: 10.1021/ol201532k

(59) Catalytic Diastereoselective Petasis Reactions. Muncipinto, G.; Moquist, P. N.; Schreiber, S. L.; Schaus, S. E. Angew. Chem. Int. Ed., 2011, 50, 8172-8175. DOI: 10.1002/anie.201103271

(58) Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions. Wu, J.; Becerril, J.; Lian, Y.; Davies, H. M. L.; Porco, J. A., Jr.,; Panek, J. S. Angew. Chem. Int. Ed., 2011, 50, 5938-5942. DOI: 10.1002/anie.201101366

(57) Discovery of New Antimalarial Chemotypes Through Chemical Methodology & Library Development. Brown, L. E.; Cheng, K. C.-C.; Wei, W.-G.; Yuan, P.; Dai, P.; Trilles, R.; Ni, F.; Yuan, J.; MacArthur, R.; Guha, R.; Johnson, R. L.; Su, X.-z.; Dominguez, M. M.; Snyder, J. K.; Beeler, A. B.; Schaus, S. E.; Inglese, J.; Porco, J. A. Jr. Proc. Natl. Acad. Sci. USA, 2011, 108, 6775-6780. DOI: 10.1073/pnas.1017666108

(56) Multicomponent Mannich Reactions with Boron Enolates Derived from Diazo Esters and 9-BBN. Luan, Y.; Schaus, S. E. Org. Lett., 2011, 13, 2510-2513. DOI: 10.1021/ol200766t

(55) Potent Inhibitors of Hepatitis C Core Dimerization as New Leads for Anti-hepatitis C Agents.. Ni, F.; Kota, S.; Takahashi, V.; Strosberg, A.D.; Snyder, J.K. Bioorg. Med. Chem. Lett., 2011, 21, 2198-2202. DOI: 10.1016/j.bmcl.2011.03.014

(54) Core as a Novel Viral Target for Hepatitis C Drugs. Strosberg, A. D.; Kota, S.; Takahashi, V. Snyder, J. K. Viruses, 2010, 2, 1734-1751. DOI: 10.3390/v2081734

(53) Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituted Cyclohexadienes. Jones, A. L.; Snyder, J. K. Org. Lett., 2010, 12, 1592-1595. DOI: 10.1021/ol100318f

(52) A Time-Resolved Fluorescence-Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization. Kota, S.; Scampavia, L.; Spicer, T.; Beeler, A. B; Takahashi, V.; Snyder, J. K.; Porco, J. A., Jr; Hodder, P.; Strosberg, A. D. Assay Drug Dev. Technol.2010, 8, 96-105. DOI: 10.1089/adt.2009.0217

(51) Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans. Medeiros, M. R.; Narayan, R. S.; McDougal, N. T.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett., 2010, 12, 3222-3225. DOI: 10.1021/ol101144k

(50) Enantioselective Synthesis of 3,4-Chromanediones via Asymmetric Rearrangement of 3-Allyloxyflavones. Marie, J.-C.; Xiong, Y.; Min, G. K.; Yeager, A. R.; Taniguchi, T.; Berova, N.; Schaus, S. E.; Porco, J. A., Jr. J. Org. Chem., 2010, 75, 4584-4590. DOI: 10.1021/jo100889c

(49) Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones. Goodell, J. R.; Leng, B.; Snyder, T. K.; Beeler, A. B; Porco, J. A., Jr. Synthesis, 2010, 13, 2254-2270. DOI: 10.1055/s-0029-1218813

(48) Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation. Kinoshita, H.; Ingham, O.J.; Ong, W. W.; Porco, J. A., Jr.; Beeler, A. B; J. Org. Chem., 2010, 132, 6412-6418. DOI: 10.1021/ja100346w

(47) Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers. Treece, J.L.; Goodell, J.R.; Vander Velde, D. ; Porco, J. A., Jr.; Aube, J. J. Org. Chem., 2010, 75, 2028-2038. DOI: 10.1021/jo100087h

(46) Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary. Jones, A. L.; Liu, X; Snyder, J.K. Tetrahedron Lett., 2010, 51, 1091-1094. DOI: 10.1016/j.tetlet.2009.12.108

(45) Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles. Liang, B.; Kalidindi, S.; Porco, J. A., Jr.; Stephenson, C. R. J. J. Org. Chem., 2010, 12, 572-575. DOI: 10.1021/ol902764k

(44) New Small Molecule Inhibitors of Hepatitis C Virus. Wei, W.; Cai, C.; Kota, S.; Takahashi, V.; Ni, F.; Strosberg, A. D.; Snyder J. K. Bioorg. Med. Chem. Lett., 2009, 19, 6926-6930. DOI: 10.1016/j.bmcl.2009.10.070

(43) Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds. Goodell, J. R.; McMullen, J. P.; Zaborenko, N.; Maloney, J. R.; Ho, C.-X.; Jensen, K. F.; Porco, J. A., Jr.; Beeler, A. B . J. Org. Chem., 2009, 74, 6169-6180. DOI: 10.1021/jo901073v

(42) Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations. Castaldi, M. P.; Troast, D.M.; Porco, J. A., Jr. Org. Lett., 2009, 11, 3362-3365. DOI: 10.1021/ol901201k

(41) Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols. Zhang, Y.; Panek, J. S. Org. Lett., 2009, 11, 3366-3369. DOI: 10.1021/ol901202t

(40) Enantioselective Addition of Boronates to Acyl Imines Catalyzed by Chiral Biphenols. Bishop, J. A.; Lou, S.; Schaus, S. E. Angew. Chem. Int. Ed., 2009, 48, 4337-4340. DOI: 10.1002/anie.200901023

(39) Reaction Discovery Employing Macrocycles: Transannular cyclizations of macrocyclic bis-lactams. Han, C.; Rangarajan, S.; Voukides, A. C.; Beeler, A. B.; Johnson, R.; Porco, J. A., Jr. Jr. Org. Lett., 2009, 11, 413-416. DOI: 10.1021/ol802729f

(38) Intramolecular Rhodium-Catalyzed [2 + 2 + 2] Cyclizations of Diynes with Enones. Jones, A.; Snyder, J. K. J. Org. Chem., 2009, 74, 2907-2910. DOI: 10.1021/jo9001678

(37) Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor. Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J. A., Jr. Angew. Chem. Int. Ed., 2009, 48, 1494-1497. DOI: 10.1002/anie.200805486

(36) Asymmetric Petasis Reactions Catalyzed by Chiral Biphenols. Lou, S.; Schaus, S. E. J. Am. Chem. Soc., 2008, 130, 6922-6923. DOI: 10.1021/ja8018934

(35) Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds. Zhou, Y.; Beeler, A. B.; Cho, S.; Wang, Y.; Franzblau, S. G.; Snyder, J. K. J. Comb. Chem., 2008, 10, 534-540. DOI: 10.1021/cc800038r

(34) Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidated Dearomatization/[4+2] Dimerization Cascade. Dong, S.; Zhu, J.; Porco, J. A., Jr. J. Am. Chem. Soc., 2008, 130, 2738-2739. DOI: 10.1021/ja711018z

(33) Organocatalytic asymmetric Mannich reactions. New Methodology, Catalyst Design, and Synthetic Applications. Ting, A.; Schaus, S. E. Eur. J. Org. Chem., 2007, 35, 5797-5815. DOI: 10.1002/ejoc.200700409

(32) Asymmetric Mannich Reaction of Dicarbonyl Compounds with a-Amido Sulfones Catalyzed by Cinchona Alkaloids and Synthesis of Chiral Dihydropyrimidones. Lou, S.; Dai, P.; Schaus, S. E. J. Org. Chem., 200772, 9998-10008. DOI: 10.1021/jo701777g

(31) Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes. Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Org. Lett., 2007, 9, 5203-5206. DOI: 10.1021/ol7023778

(30) 1,2-Dihydroisoquinolines as Templates for Cascade Reactions to Access Isoquinoline Alkaloid Frameworks. Su, S.; Porco, J. A., Jr. Org. Lett., 2007, 9, 4983-4986. DOI: 10.1021/ol702176h

(29) Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen. Peng, L. F.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W. H.; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A., Jr.; Schreiber, S. L.; Chung, R. T. Antimicrob. Agents Chemother., 2007, 51, 3756-3759. DOI: 10.1128/AAC.00233-07

(28) Nucleophilic Addition to N-Phosphinylimines Via Rare Earth Metal Triflate/Trifluoroacetic Anhydride Activation. Ong, W.W.; Beeler, A.B.; Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Angew. Chem. Int. Ed., 2007, 46, 7470-7472. DOI: 10.1002/anie.200700694

(27) Skeletal Diversity through Radical Cyclization of Tetrahydropyridine Scaffolds. Dandapani, S.; Duduta, M.; Panek, J. S.; Porco, J. A., Jr. Org. Lett., 2007, 9, 3849-3852. DOI: 10.1021/ol701722z

(26) Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerizaton/Dipolar Cycloaddition. Su, S.; Porco, J. A., Jr. J. Am. Chem. Soc., 2007, 129, 7744-7745. DOI: 10.1021/ja072737v

(25) 1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development. Woo, G.H.C.; Beeler, A.B.; Snyder, J.K. Tetrahedron, 2007, 63, 5649-5655. DOI: 10.1016/j.tet.2007.04.003

(24) An Approach to Skeletal Diversity Using Functional Group Pairing of Multifunctional Scaffolds. Comer, E.; Rohan, E.; Deng, L.; Porco, J. A., Jr. Org. Lett., 2007, 9, 2123-2126. DOI: 10.1021/ol070606t

(23) Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds. Chen, Y.; Porco, J. A., Jr.; Panek, J. S. Org. Lett., 2007, 9, 1529-1532. DOI: 10.1021/ol070321g

(22) Synthesis of Carbamates and Ureas Using Zr(IV)-Catalyzed Exchange Processes. Han, C.; Porco, J. A., Jr. Org. Lett., 2007, 9, 1517-1520. DOI: 10.1021/ol0702728

(21) Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations. Zhou, Y.; Porco, J. A., Jr.; Snyder, J. K. Org. Lett., 2007, 9, 393-396. DOI: 10.1021/ol0625280

(20) Discovery of Chemical Reactions through Multidimensional Screening. Beeler, A. B.; Su, S.; Singleton, C. A.; Porco, J. A., Jr. J. Am. Chem. Soc., 2007, 129, 1413-1419. DOI: 10.1021/ja0674744

(19) Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets. Dandapani, S.; Lan, P.; Beeler, A. B.; Beischel, S.; Abbas, A.; Roth, B. L., Porco, J. A., Jr.; Panek, J. S. J. Org. Chem., 2006, 71, 8934-8945. DOI: 10.1021/jo061758p

(18) Asymmetric Allylboration of Ketones Catalyzed by Chiral Diols. Lou, S.; Moquist, P. N.; Schaus, S. E. J. Am. Chem. Soc., 2006, 128, 12660-12661. DOI: 10.1021/ja0651308

(17) Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds. Yeager, A. R.; Min, G. K.; Porco, J. A., Jr.; Schaus, S. E. Org. Lett., 2006, 8, 5065-5068. DOI: 10.1021/ol0618252

(16) Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes. Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett., 2005, 7, 4435-4438. DOI: 10.1021/ol0516723

(15) A new, chiral anthracene for the Diels-Alder/retro-Diels-Alder sequence in lactam and butenolide synthesis. Sanyal, A.; Yuan, Q.; Snyder, J. K. Tetrahedron Lett., 2005, 46, 2475-2478. DOI: 10.1016/j.tetlet.2005.02.046

(14) Chiral Anthracene and Anthrone templates as Stereocontrolling Elements in Diels-Alder/Retro Diels-Alder Sequences. Burgess, K. l.; Corbett, M. S.; Eugenio, P.; Lajkiewicz; N. J.; Liu, X.; Sanyal, A.; Yan, W.; Yuan, Q.; Snyder, J. K. Bioorg, Med. Chem., 2005, 13, 5299-5309. DOI: 10.1016/j.bmc.2005.06.025

(13) Asymmetric Mannich Reactions of beta- Keto Esters with Acyl Imines Catalyzed by Cinchona Alkaloids. Lou, S.; Taoka, M. B.; Ting, A.; Schaus, S. E. J. Am. Chem. Soc., 2005, 127, 11256-11257. DOI: 10.1021/ja0537373

(12) Chemical Library Synthesis Using Convergent Approaches. Beeler, A. B.; Schaus, S. E.; Porco, J. A., Jr. Curr. Opin. Chem. Bio., 2005, 9, 277-284. DOI: 10.1016/j.cbpa.2005.04.005

(11) Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters. Beeler, A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem., 2005, 7, 673-681. DOI: 10.1021/cc050064b

(10) Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds. Lei, X.; Zaarur, N.; Sherman, M. Y.; Porco, J. A., Jr. J. Org. Chem., 2005, 70, 6474-6483. DOI: 10.1021/jo050956y

(9) Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling. Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J. R.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett., 2005, 7, 2751-2754. DOI: 10.1021/ol051023r

(8) Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger. Lei, X.; Porco, J. A., Jr.; Org. Lett., 2004, 6, 795-798. DOI: 10.1021/ol036502+

(7) Intramolecular Inverse-Electron-Demand Diels-Alder Reactions of Imidazoles with 1,2,4-Triazines : A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles. Lahue, R. B.; Lo, S.-M.; Woo, G. H. C.; Snyder, J. K. J. Org. Chem., 2004, 69, 7171- 7182. DOI: 10.1021/jo040193z

(6) Synthesis of Complex Alkoxyamines Using a Polymer-Supported N-Hydroxyphthalimide. Su, S.; Giguere, J. R.; Schaus, S. E.; Porco, J. A., Jr. Tetrahedron, 2004, 60, 8645-8657. DOI: 10.1016/j.tet.2004.05.109

(5) Stereochemical Diversity through Cyclodimerization : Synthesis of Polyketide-like Macrodiolides. Su, Q.; Beeler, A. B.; Lobkovsky, E.; Porco, J. A., Jr.; Panek, J. S. Org. Lett., 2003, 5, 2149-2152. DOI: 10.1021/ol034608z

(4) The Development of a Chromatography-Free Mitsunobu Reaction : Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent. Lan, P.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Comb. Chem., 2003, 5, 660-669. DOI: 10.1021/cc030028h

(3) Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst. Lan, P.; Berta, D.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Org. Chem., 2003, 68, 9678-9686. DOI: 10.1021/jo035129g

(2) Combinatorial Synthesis of Natural Product-like Molecules Using a First Generation Spiroketal Scaffold. Kulkarni, B. A.; Roth, G. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Comb. Chem., 2002, 4, 56-72. DOI: 10.1021/cc010047w

(1) Parallel Synthesis and Purification using Anthracene-Tagged Substrates. Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett., 2000, 2, 3509-3512. DOI: 10.1021/ol202772k