Tagged: Sean Elliott
Their research provides strong evidence that Flavin Adenine Dinucleotide (FAD) plays a structural role in the formation of tetrameric AidB. While their studies clearly show FAD-dependent oligomerization of AidB, they do not address whether FAD also has a catalytic function. However, the picture of AidB that is emerging invokes a role for the DNA-binding domain in localization of AidB to specific genes, while the protective function appears to reside elsewhere on the protein.
In future work, the collaborators will investigate whether this protective function resides with FAD or whether FAD was retained in the evolutionary process solely for its ability to stabilize the AidB tetramer.
This work was supported by National Institutes of Health Grants R01-GM072663 (to Sean Elliott) and P30-ES002109 (to Catherine Drennan) and National Science Foundation Grant MCB-0543833 (Drennan). Professor Drennan is a Howard Hughes Medical Institute Investigator.
The paper is available at http://pubs.acs.org/doi/full/10.1021/bi201340t, or click on the image below.
Disulfide bonds play critical catalytic, structural and signaling roles throughout nature. However, little is known about what governs their reactivity at the molecular level. To gain insights into disulfide bonds, the National Science Foundation, has funded Professor Sean Elliott and his Research Group to use direct electrochemistry to characterize the influence of protein sequence and structure on the redox properties and reactivity of the thioredoxin superfamily.
The 4-year award, which is valued at nearly $700K will provide a new detailed understanding of how thioredoxins are used in Nature to maintain redox homeostasis. The broader impacts of this work will touch deeply on the interface of chemistry and biology. Whether in plant biochemistry, bioenergy sciences or microbial physiology – thioredoxins will provide insights on how disulfide bonds are used to achieve chemical change in life.
Illuminating this process in a fundamental way will translate into new appreciation of fundamental biology. At the same time, the research will advance the training of at all levels (undergraduates, graduate students, post-doctoral faculty fellows) to think quantitatively and chemically in the field of redox biochemistry.
Professor Sean Elliott has received a second Scialog Award from the Research Corporation for Science Advancement. This very competitive award recognizes the highly innovative nature of his work and its potential to be transformative in solar energy conversion.
The project, “High Spatial Resolution Electrochemistry of Biological Inspired Systems,” is a collaboration between Professor Elliott and two other Scialog Awardees, Professor Stefan Lutz, Emory University, and Professor David Cliffell, Vanderbilt University.
Their goal is to address key bottlenecks in the development of biologically inspired systems for solar to fuel production.
The Department of Chemistry prides itself on faculty who attain an admirable balance between their research and scholarship and their commitment to teaching and advising. Two of our faculty, Professor Sean Elliott and Professor John Caradonna, both renowned researchers, were singularly honored by the College of Arts and Sciences with undergraduate advising and teaching awards.
Sean Elliott received a 2008 Templeton Prize for Excellence in Student Advising. Student recommendations for Professor Elliott were notable for their length and enthusiasm, commenting on how he inspires students and “adds a personal touch to every appointment with his jokes and his clear and present attentiveness.” Prof. Elliott is one of the inaugural recipients of this award, which was endowed by John and Josephine Templeton as a measure of their appreciation for the dedication of members of the Boston University faculty in advising, teaching, and nurturing undergraduates.
John Caradonna received the College of Arts and Sciences’ highest teaching award in 2008, the Gitner Award for Distinguished Teaching. The department’s exit interviews with the graduating majors of the class of 2008 listed him as among the top two professors in the department, and the majority picked his inorganic chemistry course as the very best experience of their undergraduate careers. The Gitner Award for Distinguished Teaching is given every year on Class Day to faculty members whose classroom leadership and student mentoring have been judged outstanding by their departments and by the Dean of the College of Arts and Sciences. The basis of the awards is excellent and distinguished teaching in the broadest sense, including classroom performance, course and curriculum development, advising, and enhancement of the scholarship of teaching and learning.
Professor Sean J. Elliott (Inorganic Chemistry) joined our faculty in Fall 2002. Sean received his B.A. summa cum laude from Amherst College in 1994 in Chemistry and English. He received his Ph.D. with Sunney Chan at Caltech 2000, for his work on the enzymology and biophysical characterization of the copper centers of particulate methane monooxygenase.
Sean comes to us most recents from his postdoctoral studies at the University of Oxford, where he worked with Professor Fraser Armstrong in the Inorganic Chemistry Laboratory (2000-2002). There he used the technique of protein film voltammetry to probe the electron transfer mechanisms of respiratory and oxidoreductase enzymes. We are very pleased to have Dr. Elliott as the newest member of the Chemistry Department.