ScienceDaily, has featured the research of a team of Boston University scientists in which they identified a novel compound that inhibits viruses from replicating.
The findings, which were published online in the Journal of Virology, could lead to the development of highly targeted compounds to block the replication of poxviruses, such as the emerging infectious disease, Monkeypox.
Investigators from the Boston University School of Medicine (Dr. Ken Dower and Dr. John Connors) teamed with Professor Scott Schaus to use a library of chemicals from the CMLD-BU to identify compounds that could stop vaccinia from replicating inside human cells.
Professor Schaus is Associate Professor in the Boston University Department of Chemistry. The Center for Chemical Methodology and Library Development at Boston University (CMLD-BU) is an National Institutes of Health Funded Center of Excellence in the area of chemical methodology and library development.
Read the ScienceDaily article at:
CMLD-BU researchers Bradley Balthaser, Meghan Maloney, Aaron Beeler, John Porco & John Snyder, in a paper published in the journal Nature Chemistry [23 OCTOBER 2011 | DOI: 10.1038/NCHEM.1178], present a new approach to accessing new, biorelevant structures by “remodeling” natural products. In this case, they demonstrate how the natural product derivative fumagillol can been remodeled to access a collection of new molecules using highly efficient chemical reactions.
The Boston University Center for Chemical Methodology & Library Development (CMLD) will host their 12th Annual Symposium, Chemical Synthesis: Advances and Applications, on Friday, June 24th, 2011 at the Boston University Photonics Center.
The speakers are:
- Professor Jef K. DeBrabander, University of Texas Southwestern Medical Center
- Natural Products: An Opportunity for Discovery
- Professor Wilfred A. van der Donk, University of Illinois at Urbana-Champaign
- Post-translational Modifications in Natural Product Biosynthesis
- Doctor Deborah T. Hung, Harvard Medical School
- Chemical Biological Approaches to Tuberculosis
- Professor Erik J. Sorensen, Princeton University
- Design and Synthesis of Molecular Scaffolds with Anti-Infective Activity
See the CMLD’s website for the schedule and how to register to attend:
The Ignition Award Program provides funds to evolve BU research to the stage where it can be licensed, form the basis of a new company, or be used to create a new, non-profit social enterprise. In June 2010, two Chemistry faculty, John Porco and John Snyder, received these highly competitive awards for their respective commercially promising projects.
Professor Porco’s research is the “Development of Novel Protein Synthesis Inhibitors as Chemotherapeutic Agents.” The work will involve synthesis of novel silvestrol (rocaglate) derivatives and their evaluation as protein translation inhibitors in the Pelletier laboratory at McGill University. Promising derivatives will be tested in the National Cancer Institute’s 60 cancer cell line panel and then advanced to animal models for B-cell leukemias and other cancers that are highly susceptible to translational control.
Professor Snyder’s research focuses on the “Development of New Anti-Tuberculosis Agents.” Three synthetic compounds from the Center for Chemical Methodology and Library Development (CMLD-BU) were determined to be “hits” against Mycobacterium tuberculosis, the tuberculosis-inducing microorganism. The preliminary biological activity data against M. tuberculosis, coupled with the unique structures of the lead compounds have justified advancing these compounds toward commercialization through the biological assays needed to establish the scope of activity and bioavailability.
Professor John A. Porco, Jr. has received the distinguished 2003 Bristol-Myers Squibb (BMS) Award in Synthetic Organic Chemistry. The grant provides a total of $300,000 of unrestricted research support over a three-year period and is one of only two given by BMS worldwide each year to support the academic research community.
The award acknowledges the outstanding record of achievement of Professor Porco and his research team in the field of synthetic organic chemistry. Synthetic organic chemistry has long been a critical tool in the drug discovery efforts of pharmaceutical companies and biotechnology firms. Research in the Porco laboratory focuses on the development of new synthetic methodology for the efficient chemical synthesis of complex molecules and the utilization of parallel (or combinatorial) synthesis techniques towards the synthesis of complex chemical libraries.
Recent total synthesis accomplishments include the synthesis of the salicylate enamide natural products lobatamide C and oximidine II, and the epoxyquinoid natural products torreyanic acid, epoxyquinol A, and panepophenanthrin. The Porco team recently employed parallel synthesis approaches to prepare complex spiroketal libraries and highly functional angular structures from epoxyquinol dienes. Professor Porco is the Director of the new Center for Chemical Methodology and Library Development at Boston University (CMLD-BU).