Tagged: CMLD

Schaus & Virus Research Featured in ScienceDaily

January 18th, 2012 in CMLD, Front Page, Research, Schaus, Scott

Professor Scott Schaus

Professor Scott Schaus

ScienceDaily, has featured the research of a team of Boston University scientists in which they identified a novel compound that inhibits viruses from replicating.

The findings, which were published online in the Journal of Virology, could lead to the development of highly targeted compounds to block the replication of poxviruses, such as the emerging infectious disease, Monkeypox.

Investigators from the Boston University School of Medicine (Dr. Ken Dower and Dr. John Connors) teamed with Professor Scott Schaus to use a library of chemicals from the CMLD-BU to identify compounds that could stop vaccinia from replicating inside human cells.

Professor Schaus is Associate Professor in the Boston University Department of Chemistry. The Center for Chemical Methodology and Library Development at Boston University (CMLD-BU) is an National Institutes of Health Funded Center of Excellence in the area of chemical methodology and library development.

Read the ScienceDaily article at:

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CMLD Researchers Publish Paper on “Remodeling” Natural Products in Nature Chemistry

November 7th, 2011 in Beeler, Aaron, CMLD, Front Page, Porco, John, Publications, Snyder, John

CMLD-BU researchers Bradley Balthaser, Meghan Maloney, Aaron Beeler, John Porco & John Snyder, in a paper published in the journal Nature Chemistry [23 OCTOBER 2011 | DOI: 10.1038/NCHEM.1178], present a new approach to accessing new, biorelevant structures by “remodeling” natural products. In this case, they demonstrate how the natural product derivative fumagillol can been remodeled to access a collection of new molecules using highly efficient chemical reactions.

a, Selective formation of perhydroisoindoles, perhydroisoquinolines or morpholinones with phenylalanine as a reaction partner: (i) phenylalanine (2.0 equiv.), M(OTf)n (50 mol%), DTBMP (1.5 equiv.), toluene, 60 °C; (ii) NaOH (2.0 M), tetrahydrofuran, room temperature, 6 h. DTBMP, 2,6-di-tert-butyl-4-methylpyridine; Phe, phenylalanine. b, Molecular models of phenylalanine-derived morpholinones 18 and 21.

a, Selective formation of perhydroisoindoles, perhydroisoquinolines or morpholinones with phenylalanine as a reaction partner: (i) phenylalanine (2.0 equiv.), M(OTf)n (50 mol%), DTBMP (1.5 equiv.), toluene, 60 °C; (ii) NaOH (2.0 M), tetrahydrofuran, room temperature, 6 h. DTBMP, 2,6-di-tert-butyl-4-methylpyridine; Phe, phenylalanine. b, Molecular models of phenylalanine-derived morpholinones 18 and 21.

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CMLD Symposium 2011

June 10th, 2011 in CMLD

The Boston University Center for Chemical Methodology & Library Development (CMLD) will host their 12th Annual Symposium, Chemical Synthesis: Advances and Applications, on Friday, June 24th, 2011 at the Boston University Photonics Center.

CMLD Symposium 2011

CMLD Symposium 2011

The speakers are:

See the CMLD’s website for the schedule and how to register to attend:

http://cmld.bu.edu/events/symposium/

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Chemistry Faculty Receive BU Ignition Awards to Develop Promising Cancer & Tuberculosis Drugs

July 12th, 2010 in Award, Faculty, Front Page, Ignition Award, Porco, John, Snyder, John

The Ignition Award Program provides funds to evolve BU research to the stage where it can be licensed, form the basis of a new company, or be used to create a new, non-profit social enterprise. In June 2010, two Chemistry faculty, John Porco and John Snyder, received these highly competitive awards for their respective commercially promising projects.

Professor Porco’s research is the “Development of Novel Protein Synthesis Inhibitors as Chemotherapeutic Agents.” The work will involve synthesis of novel silvestrol (rocaglate) derivatives and their evaluation as protein translation inhibitors in the Pelletier laboratory at McGill University. Promising derivatives will be tested in the National Cancer Institute’s 60 cancer cell line panel and then advanced to animal models for B-cell leukemias and other cancers that are highly susceptible to translational control.

Professor Snyder’s research focuses on the “Development of New Anti-Tuberculosis Agents.” Three synthetic compounds from the Center for Chemical Methodology and Library Development (CMLD-BU) were determined to be “hits” against Mycobacterium tuberculosis, the tuberculosis-inducing microorganism. The preliminary biological activity data against M. tuberculosis, coupled with the unique structures of the lead compounds have justified advancing these compounds toward commercialization through the biological assays needed to establish the scope of activity and bioavailability.

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Professor John Porco Receives Bristol-Myers Squibb Award in Synthetic Organic Chemistry

September 13th, 2003 in Award, Porco, John

Professor John A. Porco, Jr. has received the distinguished 2003 Bristol-Myers Squibb (BMS) Award in Synthetic Organic Chemistry. The grant provides a total of $300,000 of unrestricted research support over a three-year period and is one of only two given by BMS worldwide each year to support the academic research community.

The award acknowledges the outstanding record of achievement of Professor Porco and his research team in the field of synthetic organic chemistry. Synthetic organic chemistry has long been a critical tool in the drug discovery efforts of pharmaceutical companies and biotechnology firms. Research in the Porco laboratory focuses on the development of new synthetic methodology for the efficient chemical synthesis of complex molecules and the utilization of parallel (or combinatorial) synthesis techniques towards the synthesis of complex chemical libraries.

Recent total synthesis accomplishments include the synthesis of the salicylate enamide natural products lobatamide C and oximidine II, and the epoxyquinoid natural products torreyanic acid, epoxyquinol A, and panepophenanthrin. The Porco team recently employed parallel synthesis approaches to prepare complex spiroketal libraries and highly functional angular structures from epoxyquinol dienes. Professor Porco is the Director of the new Center for Chemical Methodology and Library Development at Boston University (CMLD-BU).

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