Bioinorganic Chemistry of Titanium in Medicine and the Environment


Professor Ann Valentine

Department of Chemistry

Yale University



            Titanium is not widely appreciated as a “biological metal,” even though it accumulates in (and can be used to image or treat) tumors, it gets transported around the body and affects bacterial growth, and it is sequestered to remarkable concentrations by some marine organisms. The aqueous chemistry of Ti(IV) is challenging because the ion is so prone to hydrolysis. This talk will report on our studies of titanium coordination chemistry under biologically and environmentally relevant conditions, and of the interactions of titanium ions and complexes with biological molecules.



Tinoco, A. D.; Eames, E. A.; Valentine, A. M. “Reconsideration of Serum Ti(IV) Transport: Albumin and Transferrin Trafficking of Ti(IV) and Its Complexes” J. Am. Chem. Soc. 2008, in press.


Cole, K. E.; Valentine, A. M. “Spermidine and Spermine Catalyze the Formation of Nanostructured Titanium Oxide” Biomacromolecules 2007, 8, 1641-1647


Tinoco, A. T.; Incarvito, C. D.; Valentine, A. M. “Calorimetric, Spectroscopic, and Model Studies Provide Insight Into the Transport of Ti(IV) by Human Serum Transferrin”  J. Am. Chem. Soc. 2007, 129, 3444-3454.


Cole, K. E.; Ortiz, A. N.; Schoonen, M. A., Valentine, A. M. “Peptide- and Long-Chain Polyamine- Induced Synthesis of Micro- and Nanostructured Titanium Phosphates” Chem. Mater. 2006, 18, 4592-4599.


Uppal, R.; Incarvito, C. D.; Lakshmi, K. V.; Valentine, A. M. “Aqueous Spectroscopy and Redox Properties of Carboxylate-Bound Titanium” Inorg. Chem. 2006, 45, 1795-1804.


Cole, K. E.; Valentine, A. M. “Titanium Biomaterials: Titania Needles in the Test of the Foraminiferan Bathysiphon argenteusDalton Transactions 2006, 3, 430-432.


Tinoco, A. D.; Valentine, A. M. “Ti(IV) Binds to Human Serum Transferrin More Tightly Than Does Fe(III)” J. Am. Chem. Soc. 2005, 127, 11218-11219.


Collins, J. M.; Uppal, R.; Incarvito, C. D.; Valentine, A. M. “Titanium(IV) Citrate Speciation and Structure under Environmentally and Biologically Relevant Conditions” Inorg. Chem. 2005, 44, 3431-3440.


Jan 2008