Departmental Seminar Series – Spring 2008
Synthesis of Carbohydrate Immunostimulants and Bioactive Alkaloids
David Y. Gin, Ph.D.
Member, Tri-Institutional Professor
Memorial Sloan-Kettering Cancer Center
The development and use of dehydrative glycosylation reactions allow for the synthesis of complex saponin adjuvants for clinical evaluation of conjugate cancer vaccines. The exploration of hetero-cycloaddition reactions reveals new strategies for the synthesis of anti-proliferative and anti-arrhythmia alkaloids.
Refs: JACS 2006, 128, 11915; JACS 2006, 128, 8734.