Selected Publications - John Caradonna

Non-Heme Iron Tetrahydropterin Dependent Monooxygenases:

"Circular Dichrosism and Magnetic Circular Dichrosism Spectroscopy of the Catalytically Competent Ferrous Active Site of Phenylalanine Hydroxylase and its Interactions with Pterin Cofactor",Kemsley, J.N.; Mitic, N.; Zaleski, K.L.; Caradonna, J.P.; Solomon, E.I. , (J. Am. Chem. Soc., 1999, 121, 1528-1536).

"Spectroscopic Characterization of the Catalytically Competent Ferrous Site of the Resting, Activated, and Substrate-Bound Forms of Phenylalanine Hydroxylase",. Loeb, K.; Westre, T.; Kappock, Mitic, N.; T.J.; Glasfeld, E.; Caradonna, J.P.; Hedman, B.; Hodgson, K.; Solomon, E.I. , (J. Am. Chem. Soc. 1997, 119, 1901-1915).

"Pterin-Dependent Hydroxylases" in Frontiers in Metalloenzyme Chemistry, ,Kappock, T.J.; Caradonna, J.P., (Holm, R.H.; Solomon, E., Eds., 1996, 96, 2659-2756).

"5. Spectroscopic and Kinetic Properties of Unphosphorylated Rat Hepatic Phenylalanine Hydroxylase Expressed in E. coli", Kappock, T.J.; Harkins, P.C.; Friedenberg, S.; Caradonna, J.P., (1995 J. Biol. Chem. 270, 30532-30544).

Rational Protein Design:

"Construction of a Novel Iron Superoxide Dismutase by Rational Design",1. Pinto, A.L.; Hellinga, H.W.; Caradonna, J.P., (Proc. Natl. Acad. Sci. USA, 1997, 94, 5562-5567.).

"The Rational Design and Construction of an Iron-Sulfur Protein", Coldren, C.; Hellinga, H.W.; Caradonna, J.P. , (Proc. Natl. Acad. Sci. USA 1997, 94, 6635-6640. ).
Non-Heme Iron Synthetic Model Chemistry:


"Iodosylbenzene Oxidation of Alkanes, Alkenes and Sulfides Catalyzed by Binuclear Non-heme Iron Systems: Comparison of Non-heme Iron versus Heme Iron Oxidation Pathways", Mukerjee, S.; Stassinopoulos, A.; Caradonna, J.P., ( J. Am. Chem. Soc. 1997, 119, 8097-8098.).

"Binuclear Iron Metalloprotein Reactivity Models", Caradonna, J.P., ( Ed. Thorp, H., ACS Symposium Series , 1994).

"Non-Heme Fe Metalloprotein Reactivity Models", Caradonna, J.P.; Stassinopoulos, A. ,( Advances in Inorganic Biochemistry, Marzilli, L.G.; Eichhorn, G.L. Eds.; Elsevier, New York, 1993).

Metal-Mediated Protein-DNA Interactions:

" High Resolution NMR Solution Structural Studies of Finger 2 and Finger 3 of Transcription Factor Sp1:Insights into DNA Binding", Narayan, V.; Kriwacki, R.; Caradonna, J.P. , ( J. Biol. Chem., 1997, 272, 7801-1809).

"New NMR Methods for the Characterization of Bound Waters in Macromolecules", Kriwacki, R.W.; Hill, R.B.; Caradonna, J.P.; Prestegard, J.H. , ( J. Am. Chem. Soc. 1993, 115, 8907-8911.).

"Sequence-Specific Recognition of DNA by Zinc-Finger Peptides Derived from the Transcription Factor Sp1", Kriwacki, R.W.; Schultz, S.C.; Steitz, T.A.; Caradonna, J.P. ,
( Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9759-9763).