Tom Tullius

Professor, Department of Chemistry

Professor of Pharmacology and Professor of Experimental Therapeutics, Boston University School of Medicine

Bioinorganic and Biophysical Chemistry

Office: LSEB 1005
Phone: 617-353-2482
Fax: 617-353-3535
E-mail: tullius@bu.edu

Office hours: By appointment

• PhD, Stanford University, 1979
• NIH Postdoctoral Fellow, Columbia University, 1979-1982

• Herbert A. Sober Lecturer, American Society for Biochemistry and Molecular Biology, 1998
• Fellow of the American Association for the Advancement of Science, 1996
• Camille and Henry Dreyfus Teacher-Scholar, 1988-1993
• Fellow of the Alfred P. Sloan Foundation, 1988-1992
• Research Career Development Award, National Institutes of Health, 1987-1992
• Searle Scholar, 1984-1987
• National Research Service Award, National Cancer Institute, 1979-1981

National Institutes of Health

• CH 101/102 - General Chemistry
• CH 232 - Inorganic Chemistry

• My laboratory is concerned with developing and applying new methods for determining the structure of DNA and DNA-protein complexes. My group introduced the use of the hydroxyl radical as a high-resolution chemical footprinting reagent, and developed the missing nucleoside experiment as a rapid method for revealing the thermodynamically-important contacts made by a protein with its DNA binding site. At present we are using these methods to study DNA flexibility, and structural features of complexes of DNA with RNA polymerase, homeodomains, and a variety of other proteins. We are using deuterium kinetic isotope experiments to obtain detailed information on the mechanism of hydroxyl radical cleavage of DNA. We also are developing a new method for performing hydroxyl radical footprinting in vivo.

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