Corey R. J. Stephenson

Assistant Professor

Organic Chemistry

Office: SCI 287 -- Lab: SCI 292/293
Phone: (617) 358-5089 (Office)
Fax: (617) 353-6466
E-mail: crjsteph@bu.edu

Office hours: Tuesdays 11 to 12

• Post Doctoral Fellow, 2005 to 2007, ETH- Hönggerberg, Zürich, Switzerland

• Ph.D., Organic Chemistry, 2004, University of Pittsburgh, Pittsburgh, PA, USA

• B.Sc., Honours Applied Chemistry, 1998, University of Waterloo, Waterloo, ON, Canada

• Wallace Prize, University of Pittsburgh, 2002

• Phi Lambda Upsilon Travel Award, 2002

• Chair’s Scholar Grant, University of Pittsburgh, 1998

CH642-Organic Reactions and Mechanisms

My research interests include complex molecule synthesis and the development of new synthetic methodologies for the rapid generation or molecular complexity from readily available building blocks.

Stephenson Group Homepage

• “Spiroketals via Oxidative Rearrangement of Enol Ethers.” Waller, D. L.; Stephenson, C. R. J.; Wipf, P. Org. Biomol. Chem. 2007, 5, 58.

• “Highly Enantioselective Access to Primary Propargylamines: 4-Piperidinone as a Convenient Protecting Group.” Aschwanden, P.; Stephenson, C. R. J.; Carreira, E. M. Org. Lett. 2006, 8, 2437.

• “Use of transcriptional synergy to augment sensitivity of a splicing reporter assay.” Levinson, N.; Hinman, R.; Patil, A.; Stephenson, C. R. J.; Werner, S.; Woo, G. H. C.; Xiao, J.; Wipf, P.; Lynch, K. W. RNA 2006, 12, 925.

• “Divergent Multi-Component Reactions for the Synthesis of a Library of Cyclopropane Amino Acid Derived Peptidomimetics.” Wipf, P.; Werner, S.; Woo, G. H. C.; Stephenson, C. R. J.; Walczak, M. A. A.; Coleman, C. M.; Twining, L. A. Tetrahedron 2005, 61, 11488.

• “Catalytic Asymmetric Synthesis with Rh-Diene Complexes: 1,4-Addition of Arylboronic Acids to Unsaturated Esters.” Paquin, J.-F.; Stephenson, C. R. J.; Defieber, C.; Carreira, E. M. Org. Lett. 2005, 7, 3821.

• “Asymmetric Synthesis of 3,3-Diarylpropanals with Chiral Diene-Rhodium Catalysts.” Paquin, J.-F.; Defieber, C.; Stephenson, C. R. J.; Carreira, E. M. J. Am. Chem. Soc. 2005, 127, 10850.

• “A Pregnane X Receptor Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development.” Mu, Y.; Stephenson, C. R. J.; Kendall, C.; Saini, S. P. S.; Toma, D.; Ren, S.; Cai, H.; Strom, S. C.; Day, B. W.; Wipf, P.; Xie, W. Mol. Pharm. 2005, 68, 403.

• “Microwave-Assisted “Libraries from Libraries” Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides.” Wipf, P.; Coleman, C. M.; Janjic, J.; Iyer, P. S.; Fodor, M. D.; Shafer, Y. A.; Stephenson, C. R. J.; Kendall, C.; Day, B. W. J. Comb. Chem. 2005, 7, 322.

• “Three-Component Synthesis of a,b-Cyclopropyl-g-Amino Acids.” Wipf, P.; Stephenson, C. R. J. Org. Lett. 2005, 7, 1137.

• “New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylamides.” Janjic, J. M.; Mu, Y.; Kendall, C.; Stephenson, C. R. J.; Balachandran, B.; Raccor, B. S.; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. Biorg.Med. Chem. 2005, 13, 157.

• “Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.” Brisson, M.; Nguyen, T.; Vogt, A.; Yalowich, J.; Giorgianni, A.; Tobi, D.; Bahar, I.; Stephenson, C. R. J.; Wipf, P.; Lazo, J. S. Mol. Pharml. 2004, 66, 824.

• “Diversity-Oriented Synthesis of Azaspiroalkanes.” Wipf, P.; Stephenson, C. R. J.; Walczak, M. A. A. Org. Lett. 2004, 6, 3009.

• “Microwave-Assisted Synthesis of Allylic Amines: Considerable Rate Acceleration in the Hydrozirconation-Transmetalation-Aldimine Addition Sequence.” Wipf, P.; Janjic, J.; Stephenson, C. R. J. Org. Biomol. Chem. 2004, 2, 443.

• “Transition-Metal-Mediated Cascade Reactions: C,C-Dicyclopropylmethylamines by Way of Double C,C-s-Bond Insertion into Bicyclobutanes.” Wipf, P.; Stephenson, C. R. J.; Okumura, K. J. Am. Chem. Soc 2003, 125, 14694.

• “Dimethylzinc-Mediated Addition of Alkenylzirconocenes to a-Keto and a-Imino Esters.” Wipf, P.; Stephenson, C. R. J. Org. Lett. 2003, 5, 2449.

• “Dimethylzinc-Mediated Additions of Alkenylzirconocenes to Aldimines. New Methodologies for Allylic Amine and C-Cyclopropylalkylamine Syntheses.” Wipf, P.; Kendall, C.; Stephenson, C. R. J. J. Am. Chem. Soc. 2003, 125, 761.
• “Three-Component Aldimine Addition-Cyclopropanation. An Efficient New Methodology for Amino Cyclopropane Synthesis.” Wipf, P.; Kendall, C.; Stephenson, C. R. J. J. Am. Chem. Soc. 2001, 123, 5122.