John Caradonna

Professor John Caradonna

Professor John Caradonna

Degrees and Positions

  • BA/MA in Chemistry, Johns Hopkins University, 1979
  • MA/MPhil/PhD, Columbia University, 1985
  • Postdoctoral Fellow, Harvard University, 1985-87

Honors

  • National Research Service Award
  • National Cancer Institute, 1980-82
  • Pegram Award, Columbia University, 1984
  • NIH Postdoctoral Fellowship, Harvard University, 1985-87
  • Camille and Henry Dreyfus Award for Distinguished Faculty in Chemistry, 1987
  • Alfred P. Sloan Foundation Research Award, 1993-95

Research

The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

Associate Professor, Department of Chemistry
Associate Professor of Research, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
Associate Director, Graduate Program in Cellular Biology and Biochemistry
LSE 805
Phone: 617.353.1692
Fax: 617-353-6466
caradonn@bu.edu
Office Hours: By appointment
Caradonna Group Homepage