For the second year in a row, Vertex Pharmaceuticals has continued its support of Chemistry’s student organization, Boston University Women in Chemistry (BUWIC). Vertex’s 2013-2014 support will help facilitate professional development opportunities for BUWIC members and advance chemistry education for young women. BUWIC will use the funds to provide 10 conference registration fellowships, pay for seminar expenses associated with outside speakers, and advance chemistry training by bringing three high school students to experience hands-on research in BU Chemistry laboratories.
There were 15 applications from high school students for the summer research opportunity. Of these three were selected:
- Trizzi Lam, a rising high school Senior at the Pioneer Charter School of Science in Everett, MA, is working in Prof. Adrian Whitty’s lab with 2nd-year graduate student, Jennifer Chow, on protein-protein interactions, which are important in understanding signaling pathways and in the discovery of new drug molecules.
- Eden Merdasa, a rising high school Senior at Brighton High School in Brighton, MA, is working alongside first year graduate student Long Nguyen in Prof. Aaron Beeler’s lab. The research in this lab focuses on medicinal chemistry, specifically those areas pertaining to small molecule discovery, Parkinson’s disease, schizophrenia, and cystic fibrosis.
- Kimberly Zaldana, a rising high school Junior, also at the Pioneer Charter School of Science, is working in Prof. Sean Elliott’s lab with 2nd-year graduate student, Bin Li, on researching electron transfer chemistry and the functions of enzymes and proteins.
BUWIC, formed in 2005 by female graduate students in the Department, has provided its members with industry career seminars, educational workshops, networking opportunities, and with speakers from both ‘traditional’ scientific career paths (pharmaceutical industry, academia, national laboratories), as well as ‘non-traditional’ paths (science journalism, patent law, contract research). While membership is inclusive, the organization focuses on issues of particular relevance to women training for and seeking scientific careers that build on their training in Chemistry. In 2010, BUWIC initiated outreach activities to local area schools in support of chemistry education through volunteers who teach labs, lead chemistry demonstrations, tutor, and assist teachers.
Fourth-year graduate student Thomas Sisto in Prof. Ramesh Jasti’s group has been awarded the 2013-2014 AstraZeneca Fellowship in Organic Chemistry. The award is in recognition of his scientific creativity and productivity.
Tom joined the Jasti research group as a Dean’s Fellow in the Summer of 2010. Since then he has published four papers (three as a first author). Currently Tom’s research aim is to synthesize a carbon nanotube by organic synthesis. Achieving this goal will be an enormous accomplishment for organic chemistry, as well as for materials science. At the same time, he has developed a collaborative project with Prof. Colin Nuckolls‘ group at Columbia University to use cycloparaphenylenes as “seeds” to “grow” uniform carbon nanotubes by traditional chemical deposition methods. The types of nanotubes that would be produced in this proces
s would be of the armchair variety, which has 1000-fold conductivity relative to copper and would be a major achievement. AstraZeneca is a global innovation-driven biopharmaceutical company specializing in the discovery, development, manufacturing, and marketing of prescription medicines healthcare.
This May, the BU Department of Chemistry, in collaboration with the student organization, BU Women in Chemistry (BUWIC), hosted 85 students from English High School and Brighton High School (BHS) for our fifth annual Chemistry Day. The successful day was coordinated by third-year graduate student, Kathryn Summo (Schaus Group), the BUWIC Outreach Coordinator, with the assistance of faculty, graduate students, and undergraduates. Photos taken by the participants can be seen on flickr.
The day started with demonstrations of liquid nitrogen, the sublimation of carbon dioxide with pH indicators, and making “Elephant’s Toothpaste,” which according to BHS teacher, Ralph Bledsoe, created “oohs and aahs.” Students then spent time in undergraduate teaching labs performing experiments in the electrochemistry of metals (a variation on a CH 101 undergraduate lab experiment) and identifying antioxidants using glow sticks. Students then toured state-of-the-art Chemistry and Biology research laboratories with graduate student and postdoctoral researchers who described their work and what it was like to work in a research lab. The high school participants learned about about major instrumentation (e.g., NMR spectrometers and GC/MS instruments). They also entered a fruit fly lab with high-magnification microscopes fitted with video feeds and light filtration apparatuses. The day was capped off with a BBQ sponsored by the Department of Chemistry.
BU Chemistry Day is the conclusion of an outreach program coordinated by BUWIC during the spring semester. Throughout the course of the program, eight BU undergraduate students visited AP, honors, and multilingual chemistry classrooms at English High School and Brighton High School every other week to mentor students, assist teachers with instruction, perform demonstrations, and coordinate hands-on experiments.
The 2013 BU Chemistry Day was made possible by the participation of: members of BUWIC (Elizabeth Hirst, Kathryn Summo, Stephanie Maiocco, Jessica Biagi, Gina Kim, and Elizabeth Villar); teaching lab coordinators (Boris Bezverkhny and Alex Golger); graduate student volunteers (Matt Golder, Evan Judd, Tracy Meehan, and Daniele Ramella); and undergraduate “Outreachers” (Kyle Bannon (English), Zach Bogart (English), Audrey Hertenstein (English), Doug Allison, Kyle Kahveci, Ashley Mellen, Elizabeth Moss, Josh Nelson, and James Priestley.
The American Association of University Women (AAUW) has awarded Liz Hirst, a fifth year graduate student in the Jasti Group, with a year-long American Fellowship that will enable her to complete her dissertation research in the next year.
Hirst’s research is highly interdisciplinary, combining chemistry, physics, and materials science. The focus of her work is the synthesis of novel cycloparaphenylenes (CPPs) with nitrogen incorporated into the backbone. CPPs represent the smallest unit cell of a metallic carbon nanotube (CNT). Also termed carbon nanohoops, CPPs consist of all para linked benzene rings. Nitrogen-doped CPP synthesis will enable a fundamental exploration of the structure-property effects of adding nitrogen to carbon networks. This could serve as an empirical model system for understanding the electronic changes in nitrogen-doped graphitic materials. It will also allow for correlation of theoretical predictions to reality. This synthesis will also enable construction of novel carbon-based materials. Specifically, once the target CPPs are synthesized, Liz will explore incorporation of these molecules into 3-d porous carbon-based frameworks. These frameworks may have uses in energy storage and small molecule detection.
In addition to pursuing her research, Liz Hirst works to promote the representation of women in the sciences. She has played a leadership role in the BU Women in Chemistry, currently serving as the organization’s president. A hallmark of her presidency has been outreach to local area high schools and the Girl Scouts to enable students to participate in and experience chemistry research.
BU Chemistry hosted more than 100 students from the Boston Community Leadership Academy (BCLA) and English High School on May 4, 2012 for the fourth annual Chemistry Day. The morning long program began with a demonstration session given by BU Chemistry undergraduates and coordinated by Postdoctoral Faculty Fellow (PFF) Dr. Seann Mulcahy. The demonstration explored pH, having fun with liquid nitrogen, synthesizing nylon, and making “Elephant’s Toothpaste.” After the demonstration, students spent time in our undergraduate teaching labs performing experiments in electrochemistry of metals (a variation on a CH 101 undergraduate lab experiment), electrolysis of salt water, and identifying antioxidants using glow sticks. These experiments were coordinated by PFF Dr. Katie Frato with assistance by BUWIC (Boston University Women in Chemistry) president Sarah Soltau and undergraduates. Students also attended tours of state-of-the-art chemistry research labs, seeing major instrumentation such as NMR spectrometers and GC/MS instruments and testing a glove box. During these tours, graduate student and postdoctoral researchers also described their work and what it was like to work in a research lab. The morning was capped off with a BBQ sponsored by the department. Photos from the event can be seen at the BU Chemistry Flickr site.
BU Chemistry Day is the culmination of a semester long outreach program created by BUWIC and coordinated by Liz Hirst (BUWIC Outreach Coordinator). During the semester, 2-3 BU students visited classrooms at BCLA, English High School, and Brighton High School every other week to mentor students, assist teachers with instruction, perform demonstrations, and coordinate hands-on experiments.
BU Chemistry is grateful to all of those involved, with special thanks to:
Outreach co-directors: Seann Mulcahy and Katie Frato
BUWIC: Sarah Soltau (President) and Liz Hirst (Outreach Coordinator)
Teaching lab coordinator: Boris Bezverkhny
Undergraduate “Outreachers”: Kyle Kahveci, Will Lyon (English High); Shama Patel, Nicole Buechler, Holly Johnson, Pragya Kalla, James Priestley, Christopher Neil, Zach Bogart (BCLA); and Nick Russo, Josh Nelson, Doug Allison (Brighton High)
The recipient of this year’s Vertex Scholar Award is Tian Qin, a third year student in the Professor John Porco’s Research Group. His selection was based on his development of an extremely elegant and enabling synthetic methodology towards a very difficult series of natural product targets with anticancer and cytotoxic activity. This work was recently published as a Communication in the Journal of the American Chemical Society. His contributions to student mentoring are also recognized by his selection for this award award. Tian came to BU in 2008 from the Graduate University of the Chinese Academy of Science, where he majored in organic materials in chemistry.
The 2011 award is made possible by Vertex Pharmaceuticals who have provided this generous graduate fellowship in organic chemistry for an exceptional 2nd, 3rd or 4th year graduate student in our Ph.D. program. The BU-Vertex Educational Partnership Program, established in 2010, offers scholarships funded by Vertex Pharmaceuticals, a biotechnology company based in Cambridge, Massachusetts, US.
Each award funds a student’s stipend, fees, and research supplies for one year. The Vertex program is an important unencumbered gift to BU Chemistry. As part of its aim to promote cooperation between industry and academia, Vertex provides the Scholars with access to mentoring from their scientists. Vertex, with a market capitalization of more than $7.2 billion, is committed to the discovery and development of breakthrough small-molecule drugs for serious diseases.
Published in PNAS in July 2011, the paper represents their collaborative work with researchers in the BU Department of Mathematics and Statistics, Professor Eric Kolaczyk and Graduate Student Lisa Pham.
It reports on the effectiveness of their novel method, latent pathway identification analysis (LPIA), in providing insights into systemic biological pathways and key cellular mechanisms that dictate disease states, drug response, and altered cellular function. The work was supported by NIH, NSF, and DOD.
The Burroughs Wellcome Fund (BWF) uses Collaborative Research Travel Grants to facilitate biomedical research among laboratories in the US and abroad. This February, two Chemistry groups received these competitive awards.
One of the grants will support Professor Pinghua Liu and his graduate student, Jinzhao Shen, to go to Beijing to work in the laboratory of Professor Xiaoping Chen of the Chinese Academy of Sciences. They will collaborate with Professor Chen’s group to develop new anti-microbial drugs, focusing initially on new anti-malaria drugs for multi-drug resistant strains. Specifically, they will build marine natural product libraries and screen them for anti-malaria activities.
The second grant will support graduate student, Daniel Saltzberg, in the Allen Group. Mr. Saltzberg will work with Dr. Hiro Tsuruta’s group at the Stanford Synchrotron Radiation Lightsource to probe the specific interactions governing ligand binding in a large superfamily of metabolic enzymes. These studies will provide insight into the evolution of functional diversity in this superfamily.
Dr. Philip Moquist has received a postdoctoral research fellowship from the Alexander von Humboldt Foundation to study in Germany with Professor Gerhard Erker at the Westfaelische Wilhelms-Universitaet Muenster Organisch-Chemisches Institut in Muenster.
His research proposal is to work on the asymmetric activation of hydrogen using electron deficient boron complexes. The Humboldt Foundation aims to promote academic cooperation between German scientists and researchers from other countries.
Dr. Moquist received his B.S. in Chemistry at the University of California, San Diego. In 2010, he recieved his Ph.D. in Chemistry under the guidance of Professor Scott Schaus at Boston University. His work at BU included the development of enantioselective boronate reactions.
Due to the large number of e-mails that Dr. Moquist has received, we request that you do NOT contact Dr. Moquist for assistance in applying for the Fellowship.
Christina Rodrigo Receives American Cancer Society Postdoctoral Fellowship.
The goal of the American Cancer Society (ACS) fellowships is to provide talented postdoctoral research associates funding that will lead to an independent career in cancer research. This Fall, Christina Rodrigo, a postdoctoral research associate in the Porco Group received one of these highly sought national awards for her proposed work on silvestrol, a rocaglate derivative isolated from the plant Aglaia foveolata. Silvestrol has been shown to have potency against breast, lung, and prostate cancer cell lines and chronic lymphocytic leukemia B cells but little is known about about its mechanism of action.
Dr. Rodrigo’s goal is to synthesize molecules similar to silvestrol with slight modifications, and to study and compare these molecules to silvestrol to learn more about how silvestrol works as a treatment for cancer. In addition to the excellence of her proposed research and demonstrated productivity, another contributing factor for her receipt of the ACS Fellowship is the quality of the training and mentoring that she receives from Professor Porco and his Group.