Professor Linda Doerrer and fourth year graduate student, Steven Hannigan, were chosen as recipients of a Boston University Ignition Award. This program provides funds to validate early-stage research projects with clear commercial potential.
The Doerrer group has determined that a fully fluorinated copper(II) compound can electrocatalytically reduce nitrate in water. Such a technology would be extremely relevant to today’s market for water treatment systems because it addresses an increasingly significant environmental problem. Nitrate is a common component in all man-made fertilizers and is, therefore, increasingly found in all salt- and fresh-water bodies. The nitrate is a fertilizing food source for microorganisms whose excessive growths are called harmful algal blooms (HABs), which can lead to aqueous “dead zones” in rivers, seas, and lakes that can be seen from satellites.
The Ignition Award Program was launched in 2007 by the Boston University Office of Technology Development. Since then, it has issued 46 awards, 10 of which have been given to Chemistry faculty to advance their innovative ideas.
2015 NSF Graduate Research Fellowship Program (GRFP) award recipient, George Pantelopulos, has joined Chemistry to do his proposed graduate research in theoretical chemistry with Prof. John Straub and his group. George aims to model the kinetics of phase transitions in a system of components (lipids and cholesterol) commonly found in eukaryotic cell membranes using the Generalized ReplicaExchange Method (gREM) developed by the Straub group and constructing a Markov State Model (MSM) of a mixed bilayer. George believes that his study will yield a statistically detailed model of the thermodynamics and kinetics of mixed bilayer phases, something which has been sought for years via experimental techniques and previously out-of-reach for standard simulation methods.
George is no stranger to BU Chemistry. In 2013 he was one of the 10 students selected for Chemistry’s NSF site Research Experience for Undergraduates (REU) program. At the time, he was at the Community College of Philadelphia. During his summer REU program here, he helped to synthesize nanohoops of high electron density, which were hypothesized to serve as high performance coatings for solar cells. In Fall 2013 he transferred to Temple University (Philadelphia, PA), where he did research with Prof. Vincent Voelz on simulation studies of the p53-MDM2 complex. MDM2 is an ubiquitin ligase protein which downregulates the tumor suppressor protein p53. As such, inhibition of the p53-MDM2 complex is a major goal in targeted cancer therapy research.
In addition to chemistry, George’s interests are broad and varied. He has a strong commitment to community service and have volunteered with such organizations as TeenSHARP, a weekend educational program for minority students in Philadelphia and Camden schools, where he was a science instructor and Habitat for Humanity.
A publication from the research group of Professor Adrian Whitty has been selected by the Journal of Biological Chemistry (JBC) as “Paper of the Week.” This distinction is conferred upon JBC papers that the Associate Editors and Editorial Board Members consider to represent the “top 2% of JBC papers in overall importance.” The paper, “Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels,” provides a rare, quantitative view of how activation of a growth factor receptor is linked to signaling and function. The work is significant because it sheds new light on some of the factors that determine what concentration of growth factor is required to achieve a functional response, and how this functional sensitivity relates to the dose-response behavior observed for receptor activation and for intracellular signaling events. The paper also shows that experiments done using high ligand concentrations can obscure quantitative features of receptor signaling. The journal will publish a profile of the paper’s first author, 5th year graduate student Simin Li (pictured). Other Whitty group investigators who contributed to the work include Dr. Devayani Bhave and Dr. Thomas Riera (former Postdoctoral Fellows), Jennifer Chow and Mariya Atanasova (graduate students), Simone Rauch (undergraduate student), and Dr. Richard Cate (Visiting Scientist).
Mr. Chao Qi is the recipient of the 2015 Vertex Scholar Award. He is a 4th year graduate student in the group of Prof. John A. Porco. Chao was selected based on his demonstrated excellence in organic chemistry. He has developed extremely elegant and enabling synthetic methodology towards two different natural products, making reactions work, and building complex natural product architectures. Highly productive, he has two major publications, with a third manuscript nearing completion. In addition, Chao plays a leadership role in the Porco laboratory and is currently mentoring an undergraduate researcher.
The 2015 award is made possible by Vertex Pharmaceuticals which has provided this generous graduate fellowship in organic chemistry for an exceptional 2nd, 3rd or 4th year graduate student in our Ph.D. program. The BU-Vertex Educational Partnership Program, established in 2010, offers scholarships funded by Vertex Pharmaceuticals, a biotechnology company-based in Cambridge, Massachusetts, US.
Ariel Hyre, a first-year graduate student in Professor Linda Doerrer‘s laboratory, has received a 2014 NSF Graduate Research Program Fellowship on her initial attempt. NSF stated that she was awarded the 3-year fellowship based on her “outstanding abilities and accomplishments, as well as [her] potential to contribute to strengthening the vitality of the US science and engineering enterprise.” Ariel, who came to BU after receiving her BS from Brandeis University in 2013 (Cum Laude, High Honors in Chemistry), is deeply committed to materials research that will contribute to environmentally sustainable energy.
As an undergraduate, Ariel explored many aspects of chemistry, working in three different laboratories at Brandeis to learn organometallic techniques and instrumentation (with Professor Christine Thomas); engineering-based materials research (with Professor Seth Fraden); and oscillatory chemical reactions (with Professor Irving Epstein). Coming to BU, she decided to join the Doerrer Group and work on a project that focuses on synthesizing one-dimensional, heterobimetallic nanowires supported and bridged by carboxylate ligands. The infinite chains found in the crystals of these complexes will be tested for electronic conductivity to understand the fundamental design principles needed to produce highly efficient nanoscale wires for electronic devices. Other research directions within the Doerrer lab include C-H and O-H bond oxidation and facile synthesis of zero-valent iron nanoparticles.
Ariel, who minored in political science as an undergraduate, is also committed to scientific outreach, believing that a vibrant scientific community is vital to the health and development of society, at the both local and national levels. She and Professor Doerrer have exciting plans to develop a bilingual English/Spanish outreach program for the elementary school students. Their aim is to engage students from one of the most underrepresented groups in the sciences in the excitement of chemistry.
Jennifer Chow, a third-year graduate student in the group of Professor Adrian Whitty, has received an NIH Ruth L. Kirschstein National Research Service Award (NRSA). Jennifer received the award for her initial submission, which is a singular honor given how competitive this award is each year. Jennifer will receive 4 years of support to pursue her project, “Activation and Signaling Mechanism of the RET Tyrosine Kinase Receptor.”
The goal of Jennifer’s project is to develop a system using Forster resonance energy transfer (FRET) to understand the changes that occur upon binding of ligand to growth factor receptors. Aim 1 will develop the FRET constructs, which will be used in Aim 2 to investigate the mechanism of RET (REarranged during Transfection receptor) activation in cell culture. In Aim 3, potential crosstalk between the RET and vascular endothelial growth factor receptor 2 (VEGFR2) pathways will be investigated. The research will aid in the physical understanding of growth factor (GF) receptor activation and how aberrant GF receptor signaling in cancer might be therapeutically modulated.
Jennifer received her undergraduate degree from San Francisco State University (CA) and worked at an academic lab for three years after graduation. She came to BU in 2011 and joined Prof. Whitty’s research laboratory, which focuses on quantitative approaches to various fields of chemical biology. In addition to her research, Jennifer is currently the president of the Chemistry Department’s student organization, BUYCC.
Matthew Golder is the recipient of the 2013-2014 Vertex Scholar Award. The award is in recognition of his scientific creativity and leadership. Matt is a fourth-year graduate student in the group of Prof. Ramesh Jasti.
Matt has been working for the past 3 years in the development of synthetic procedures to produce cycloparaphenylenes, the simplest sub-segment of a metallic armchair carbon nanotube. His efforts have lead to three publications thus far (most recently a first author paper in Chemical Science) and several presentations at national meetings.
Matt is the fourth Vertex Scholar in the Department. The award is made possible by Vertex Pharmaceuticals, a biotechnology company based in Cambridge, Massachusetts. Each award funds a student’s stipend, fees, and travel to conferences for one year. As part of its aim to promote cooperation between industry and academia, Vertex provides the Scholars with access to mentoring from their scientists. Vertex, with a market capitalization of more than $7.2 billion, is committed to the discovery and development of breakthrough small-molecule drugs for serious diseases.
For a second year in a row, Prof. Ramesh Jasti‘s group has hosted students from the Steppingstone Foundation to share with them the excitement of nanoscale research. Steppingstone is a non-profit that develops and implements programs which prepare urban schoolchildren for educational opportunities that lead to college success.
This year the students learned about nanoscale materials and how their unique properties are a function of their size. The day started with fun demonstrations of liquid nitrogen and an “explosive” Pringles can. The students then paired off to perform two separate hands-on laboratory experiments. The first lab illustrated the principle of chemical sensing. Using glow sticks, students analyzed a number of molecules to determine their anti-oxidant properties. Strong anti-oxidants would result in decreased fluorescence that visually detectable. This approach to sensing molecules is of strong interest for detection of environmental pollutants, food safety, product testing, water treatment, explosives detection and numerous other applications.
The second lab was designed to teach the students about the importance of polymers in modern life, particularly as they relate to material applications. The student pairs synthesized their own Nylon strands. To “up the fun factor,” they were challenged to a contest to see who could produce the longest continuous piece. With a prize of candy bars on the line, the students took the challenge seriously.
The day wrapped up with a casual pizza lunch, with the visitors asking lots of questions about not only graduate school, but college life and what being a science major is like. The graduate students had as much fun as the high school visitors, and look forward to the continued partnership of the Steppingstone Foundation and the Jasti Group.
For the second year in a row, Vertex Pharmaceuticals has continued its support of Chemistry’s student organization, Boston University Women in Chemistry (BUWIC). Vertex’s 2013-2014 support will help facilitate professional development opportunities for BUWIC members and advance chemistry education for young women. BUWIC will use the funds to provide 10 conference registration fellowships, pay for seminar expenses associated with outside speakers, and advance chemistry training by bringing three high school students to experience hands-on research in BU Chemistry laboratories.
There were 15 applications from high school students for the summer research opportunity. Of these three were selected:
- Trizzi Lam, a rising high school Senior at the Pioneer Charter School of Science in Everett, MA, is working in Prof. Adrian Whitty’s lab with 2nd-year graduate student, Jennifer Chow, on protein-protein interactions, which are important in understanding signaling pathways and in the discovery of new drug molecules.
- Eden Merdasa, a rising high school Senior at Brighton High School in Brighton, MA, is working alongside first year graduate student Long Nguyen in Prof. Aaron Beeler’s lab. The research in this lab focuses on medicinal chemistry, specifically those areas pertaining to small molecule discovery, Parkinson’s disease, schizophrenia, and cystic fibrosis.
- Kimberly Zaldana, a rising high school Junior, also at the Pioneer Charter School of Science, is working in Prof. Sean Elliott’s lab with 2nd-year graduate student, Bin Li, on researching electron transfer chemistry and the functions of enzymes and proteins.