The National Institute of General Medical Sciences (NIGMS) is continuing its support of the CMLD-BU as one of five Centers of Excellence addressing the problem of how to develop small molecule libraries and techniques for making them that meet all the needs of pharmaceutical and biomedical scientists.

Category: Panek, James

NIGMS Renews Funding for the CMLD-BU

October 1st, 2008 in CMLD, NIH, Panek, James, Porco, John, Schaus, Scott, Smith, Kevin, Snyder, John, Stephenson, Corey

The National Institute of General Medical Sciences (NIGMS) is continuing its support of the CMLD-BU as one of five Centers of Excellence addressing the problem of how to develop small molecule libraries and techniques for making them that meet all the needs of pharmaceutical and biomedical scientists.

The CMLD-BU was originally established in 2002. The renewal is for another 5 years (through 2013) and is worth more than $11.5 million. The first year’s funding, $2.6 million, will be used to develop microfluidics and other strategies to synthesize small molecules for application by the biological community. The program is highly collaborative. Professor John A. Porco, Jr., who is the Director and Principal Investigator, is joined by Co-PI’s Professors Jim Panek, Scott Schaus, John Snyder, and Corey Stephenson, who are leaders in the field of organic chemistry.

The goal of the Center is to develop cutting-edge technologies to generate, analyze, and optimize chemical libraries and synthesize thousands of novel chemical entities using high-throughput techniques. It is also making these methods and libraries broadly available for biomedical research and drug discovery. The CMLD’s PI’s are collaborating with biologist, Professor Tom Gilmore, to determine the physiological activities of new molecules.

CMLD-BU Scientists Awarded National Institutes of Health Grant in Pilot-Scale Libraries for High-Throughput Screening Program

December 15th, 2005 in CMLD, Faculty, Panek, James, Porco, John, Schaus, Scott, Snyder, John

Co-investigators of the Boston University Chemical Methodology and Library Development Center (CMLD-BU) (http://cmld.bu.edu) have been awarded a three-year grant for their joint proposal “Generation of Stereochemically and Structurally Complex Chemical Libraries.” The goal of the work by Professors Porco, and co-Principal Investigators Panek, Schaus, and Snyder, is to generate a number of stereochemically and structurally complex chemical libraries for inclusion in the National Institutes of Health (NIH) Molecular Repository (http://mlsmr.glpg.com/MLSMR_HomePage/index.html). They will develop five library projects that are distinct from ongoing and planned CMLD-BU library projects, but which utilize novel chemistries previously developed in their laboratories. Target pilot libraries include complex dihydropyrimidones, azaphilone-derived libraries, tetracyclic alkaloid-type libraries, exo-methylene scaffolds and derived spirocycles, and macrocyclic lactams. In addition, all planned libraries have been designed to include unique structures that do not overlap in chemical space with molecules currently in the PubChem database. Data will be shared using an internet-based structure-searchable database of synthesis protocols.

The Molecular Libraries and Imaging Initiative is a component of the “New Pathways to Discovery” theme of the NIH Roadmap, which seeks to enable the rapid transformation of new scientific knowledge into tangible benefits for public health. While high-throughput screening (HTS) of small-molecule libraries is widespread in the pharmaceutical industry, the goal of the Molecular Libraries (ML) Roadmap Initiative is to facilitate the use of HTS and chemical libraries within the academic community. It is anticipated that the ML initiative will produce research tools (including novel small-molecule modulators of cellular function and phenotypic assays) to facilitate studies of biology and physiology (http://nihroadmap.nih.gov/molecularlibraries). It is anticipated that the initiative will complement private sector drug development efforts by contributing to the identification and validation of novel drug targets, as well as molecular structure classes with potential for development into therapeutics. The initiative promises benefits to public health, especially for rare or marginalized disorders.

John PorcoProfessor James PanekScott SchausProfessor John Snyder

Professor James Panek Named the First Samour Family Professor in Organic Chemistry

April 15th, 2004 in Faculty, Panek, James

Professor James Panek

Professor James Panek

In April 2004, Professor James Panek was named the first Samour Family Professor in Organic Chemistry. This endowed chair was established by Dr. Carlos Samour, who received his Ph.D. in Chemistry from Boston University in 1950. Dr. Samour is a respected scientist and businessman who has been a committed supporter of the College of Arts and Sciences at Boston University. He is a philanthropist whose generosity to the Department of Chemistry is now being recognized in perpetuity by the Chair that bears his family’s name. Professor Panek is the inaugural incumbent of the Samour Chair in acknowledgment of his nationally and internationally recognized accomplishments in the field of synthetic organic chemistry. Professor Panek is affiliated with Boston University’s new Center for Chemical Methodology and Library Development, established as a Center of Excellence by the National Institute of General Medical Science of the National Institutes of Health.

Professor James Panek Receives Arthur C. Cope Scholar Award

April 1st, 2002 in Award, Faculty, Panek, James

Professor Jim Panek

Professor James Panek

Professor James S. Panek has been named a recipient of the prestigious Arthur C. Cope Scholar Award sponsored by the Arthur C. Cope Fund of the American Chemical Society for his important contributions to the field of asymmetric chemical synthesis.

The award was presented before the Division of Organic Chemistry at the 224th ACS National Meeting in Boston, MA in August 2002.