Please join us in congratulating Professor Xi Ling who has just been selected to receive a University Provost’s Career Development Professorship. This award is given to a a junior faculty member who shows exceptional promise, and is particularly focussed on advancing the participation and success of women in the area of Life Sciences. This is a three-year award with funding to support research and scholarly expenses.
Congratulations to Professor Ling on the great start to her independent research career!
Professor Whitty was awarded a 4 Year grant by the National Institute of Health (NIH) to further his studies of NF-kB Modulators. The title of the Research Project is: Structure and Mechanism of NF-kB Essential Modulator (NEMO).
This funding will allow Professor Whitty and his Co-PIs Professors Karen Allen of Chemistry and Thomas Gilmore of Biology to advance our understanding of the signaling scaffold protein NF-κB essential modulator (NEMO), a component of the inhibitor of κB kinase (IKK) complex, which is a key regulatory node for NF-κB signaling. In addition to NEMO playing a role in the chronic hyperactivity of NF-κB in human diseases, mutations in NEMO are found in several human immunodeficiency diseases. The long-term goals of the project are to understand how scaffolding proteins such as NEMO use conformational change to regulate the functional interactions between the signaling proteins that are bound to them, to elucidate the structural basis for disease-causing mutations in key regions of NEMO, and to identify new target sites for small molecule drugs that modulate NEMO activity.
Congratulations to Professors Whitty, Allen and Gilmore and their research team!
Congratulations to Professor David Coker for receiving a National Science Foundation Grant (NSF) totally $435,000. This project will fund Dr. Coker and his team’s research into two areas. The first project will focus on extending, first principles, excited state quantum chemical methods and conformational sampling techniques to compute the distributions of parameters in models of the biological light harvesting systems that have received much attention in recent ultrafast nonlinear spectroscopy studies. Such models are usually employed to interpret the results of these averaged experiments. These best-fit, average models have many parameters that can be difficult to estimate and they are not generally unique, often leading to ambiguous interpretation. The theoretical methods being developed by the Coker group, however, enable detailed analysis of fluctuations underlying the average and the sampling of an ensemble of unique models that include, for example, highly performing structural outliers whose characteristics will give important understanding for optimal design, rather than mean behavior. In the second project, dissipative quantum dynamical methods are employed to compute spectroscopic properties and study relaxation processes including energy transport and charge separation using the ensembles of computed models. Preliminary work on these projects was featured in a recent publication in the Journal of the American Chemical Society.
Dr. Coker is a Professor of Theoretical and Physical Chemistry and is the Director for BU’s Center for Computational Science (BU CCS). The Coker Group focus their research the development of new theoretical and computational methods to explore how electronic and vibrational excitation of reactant molecules in different environments can influence the outcome of chemical reactions of these molecules. Because electronic and vibrational relaxation of excited reactants is fundamentally quantum mechanical in nature, the methods they use must accurately describe the transfer of energy between the classical environment and the quantal reactive system.
 “First-Principles Models for Biological Light-Harvesting: Phycobiliprotein Complexes from Cryptophyte Algae”, M.K. Lee, K. Bravaya, and D.F. Coker, J. Am. Chem. Soc., 2017, 139 (23), pp 7803–7814
We are happy to welcome a new colleague to our ranks in Professor Chen Yang. Professor Yang will be moving from the Purdue University Chemistry Department where she also has a joint appointment in Physics. Her work focuses on the development of new nanomaterials with chemically controllable functionality exploiting low dimensionality as well as structural and compositional complexity.
Chen received her PhD in Chemistry from Harvard University working in the laboratory of Professor Charles Lieber before starting her first academic appointment at Purdue in 2007. She will have a 50:50 joint appointment at BU with the Department of Chemistry and Electrical & Computer Engineering Department. She will also be a member of the Materials Science & Engineering Divisioin.
Professor Yang’s materials centered research has applications in plasmonic optical devices, solar energy utilization, nanomedicine and biological imaging, and nanoelectronics. She has won a Seeds of Success Award from Purdue University (awarded to faculty raising over 1 million dollars) and a Career Award (2009-2014) from the National Science Foundation. Her prior work has been supported by grants from NSF, DARPA, ARO and the Keck Foundation.
Please join us in welcoming Dr. Yang to BU’s Chemistry and Electrical & Chemical Engineering Departments starting on July 1st!
|On May 2 BU Nanotechnology Innovation Center (BUnano) held its inaugural symposium “Nanotechnology for Imaging”. The symposium focused on The “Nanotechnology For Imaging” symposium will be focused on highlighting accomplishments of BUnano faculty and students, and featured keynote presentation by 2014 Nobel Prize winner for Chemistry, Professor Stefan Hell.
BUnano Center Director Prof. Mark Grinstaff welcomed the audience in the packed Metcalf Trustee Ballroom. and presented BUnano’s mission to promote a vibrant and dynamic community for nano-related disciplines at BU. What distinguishes BUnano from other nano centers in the Boston area is its connection to the Boston Medical Center and the BUSM. BUnano offers pilot grants to foster and support collaborative research of BU faculty across campuses in their pursuit of finding nano solutions to real life problems in technology and medicine.
The morning session featured a lineup of talks by BUnano faculty. Dr. Luca Dal Negro opened the scientific portion of the symposium with his talk on “Materials and Fields @ the Nanoscale: Optical Engineering of Resonant Nanostructures,” followed by Dr. Allison Dennis’s talk “Cadmium-free Quantum Dots for Imaging in the Visible and Near Infrared” and the joint presentation by Drs. Joyce Wong and Victoria Herrera entitled “Janus Nanoparticles for Cancer Theranostics.” Dr. Luca Dal Negro is an Associate Professor of Electrical and Computer Engineering, Materials Science and Engineering, and Physics at BU. He introduced his group’s research related to the development of novel plasmonic materials and nanostructures for spectroscopy. Dr. Allison Dennis, Biomedical Engineering Assistant Professor, discussed how her group uses cadmium-free Quantum Dot chemistries for applications in fluorescent biosensing and improved biomedical imaging. Dr. Joyce Wang, a Professor in Biomedical Engineering and Professor of Medicine Dr. Victoria Herrera discussed their interdisciplinary collaboration on developing theranostic Janus USPION for enhanced MRI imaging and targeted nucleic acid therapy to treat non-druggable cases, especially in pancreatic cancer.
After lunch break, Dr. Selim Unlu, a BUnano affiliated faculty and professor of Electrical Engineering introduced the keynote speaker of the symposium, Prof. Stefan Hell. He is the current Director at the Max Planck Institute for Biophysical Chemistry in Germany. In 2014 Prof Hell was awarded the Nobel Prize in Chemistry for his pioneering work in the field of ultra high resolution fluorescence microscopy. Stefan Hell succeeded in radically overcoming the resolution limit of conventional optical microscopes – a breakthrough that has enabled new ground‐breaking discoveries in biological and medical research.
Prof. Hell’s exciting talk on flurorescence nanoscopy featured his recent research on how to neutralize diffraction in order to achieve imaging of cells and tissues at the nanoscale. For close to an hour, Prof Hell held the audience’s attention captive, transforming them to the realm of STED microscopy infecting them with the possibility of capturing images of the nanoworld.
Twenty students and postdoctoral fellows were selected to present their posters at the symposium. Ms Qianyun Zhang, a student in Dr. Bjoern Rheinhard’s Lab, received $500 for her poster “Illuminating EGFR clustering and its Effects on Signal.”
The symposium concluded with BUnano’s version of the popular show Shark Tank, “Terrier Tank.” The competition was moderated by Dr. Ahmad Khalil, Biomedical Engineering Assistant Professor at BU. Five finalists presented their innovative translational research idea to a panel of judges. The panel included BUnano Entrepreneur-in-Residence Dr. Jill Becker (CEO and Founder of 02139 Inc), Dr. David Coleman, Chair of the Department of Medicine at BUSM, Peter Marton of BU’s Questrom School of Business and Buzz Lab, Jess McLear of Launchpad Venture Group, and Dr. Terry Russell, Managing Director of Interface Ventures. It was truly exciting to see undergraduate students, graduate students and postdoctoral associates striving to take a nascent idea and translate into a marketable product which would provide tangible benefit to our society.
After careful consideration, the judges awarded the $10,000 prize to CatchAu – an environmentally conscious wastewater treatment idea by a team of graduate students, Mingfu Chen, Uros Kuzmanovic, and Nicolas Shu.
On Friday, May 5th, 2017 the work of 11 students was spotlighted in this year’s Undergraduate Research Symposium (URS). The outstanding quality of the projects presented underscored the importance of the hands-on, challenging research that is the hallmark of BU’s Chemistry major. The even was organized by the Undergraduate Programs Committee, Professor John Snyder and coordinated by our Undergraduate Coordinator, Lauren Jett.
URS was first instituted in 1987 by then Director of Undergraduate Studies, and now Emeritus, Prof. Mort Hoffman, and has been a much anticipated, spring’s-end annual event ever since. The Symposium is modeled along the lines of talks at an American Chemical Society (ACS) meeting: 12 minutes of presentation followed by 3 minutes of questions and discussion. Capping the day was the announcement of the Departmental Awards, followed by a celebratory BBQ for the students, their faculty advisers, graduate mentors, and their guests. To view URS photos, please click here.
Held every three years since 1972, the ACTC is widely attended by chemists from both the United States and abroad. The meeting grew from the biennial Gordon Research Conference on Theoretical Chemistry, held from 1962-1970. Sharon Hammes-Schiffer, University of Illinois at Urbana-Champaign, is the Chair of ACTC 2017. David Coker, Boston University, is the Deputy Chair and Local Organizer, and Todd Martinez, Stanford University, is the Vice Chair.
The lectures will be held at the Boston University Law School Auditorium, lunches will be at the George Sherman Union Back Court, and poster sessions will be held at Metcalf Hall in the George Sherman Union. For breakfasts and dinners, attendees will have many options of nearby restaurants. A boat trip and banquet will be held on Wednesday.
For more information and registration details click here.
New approaches to undergraduate lab classes
Melissa Marquez, a second-year graduate student in Professor Deborah Perlstein’s group, has recently received a 2017 NSF Graduate Research Fellowship. She earned a Bachelor of Science in biochemistry with a minor in mathematics from Mount Saint Mary’s University and as an undergraduate conducted research in Dr. Eric Stemp’s lab focusing on DNA-protein cross-linking resulting from oxidative damage to DNA. She was introduced to Boston by participating in Tufts University’s NSF Research Experience for Undergraduates (REU) program in the summer of 2013 and worked in Dr. Mitch McVey’s lab where she focused on determining the lethality stages in Drosophila melanogaster Werner Syndrome exonuclease mutants. Along with chemistry, Melissa enjoys serving others in their journey toward their science aspirations. She is currently a fellow for the BU NSF GK-12 Global Change Initiative (GLACIER) program where she works at Pierce School in Brookline with a 6th grade science teacher, an officer for BU Women in Chemistry, and a co-leader of the BU Graduate Women in Science and Engineering (GWSE) Girls with Goggles club, an outreach program that provides weekly hands-on activities for middle school girls.
Through the support of the NSF, Melissa aims to obtain a greater understanding of how iron cofactors are biosynthesized through the cytosolic iron sulfur cluster assembly (CIA) pathway. This system is responsible for iron sulfur (FeS) cluster biogenesis for proteins found outside of the mitochondria in eukaryotic organisms. Essential processes such as DNA replication and repair, transcription, and translation, are all dependent on at least one FeS cluster containing enzyme. A key question is: how are these DNA metabolizing enzymes, also termed targets, recognized by the CIA pathway? Melissa plans to discern the mechanism of CIA target recognition by investigating Cia2, a vital component of the CIA targeting complex known for executing target identification in the last step of the system. Not only is cluster targeting poorly understood for the CIA pathway, but it is not known how any cluster biogenesis pathway identifies its targets. By examining how targets are recognized, this work can provide a model for how target recognition is executed for other cluster biogenesis systems. Melissa is primarily interested in pursuing a career in which she can simultaneously work on innovative experimentations closely related to therapeutic development and reigniting students’ appreciation for deeper learning and, ultimately, love for science.
Dr. Sean Elliott Receives 4 Year National Institute of Health Grant to study “Structure, Function and Diversity in the Bacterial Cytochrome c Peroxidase Family”
The new grant will enable studies in the Elliott Group to dissect the way in which nature has made use of a common motif of bioinorganic chemistry, the iron-bearing structure known as a c-type heme, and to utilize it for diverse chemistry. While Elliott has a long-running interest in heme and redox chemistry, here the group studies the titular ‘bacterial cytochrome c peroxidase’ (or, bCCP) family of enzymes. While prototypical bCCPs are found in gram negative microorganisms where they detoxify endogenous or exogenous hydrogen peroxide (H2O2), the Elliott group has realized that there exist in microbes novel bCCPs which engage in unknown chemistry. In the work sponsored by the NIH, the Elliott group will use a combination of biochemistry, electrochemistry, spectroscopy and structural biology to elucidate the bCCPs found in under appreciated microbes, and attempt to rationalize why the enzymes work as they do.
The work to be supported is a team effort where the enzymes discovered and produced in the Elliott Group will be examined here at BU, but also in collaboration with structural biologists at MIT and spectroscopists at Carnegie Mellon and the University of Michigan.
As bCCPs are enzymes on the front-line of the native defenses of NIH Select List pathogens including Pseudomonas aeruginosa, Burkholderia complex species, Vibrio cholerae, Campylobacter jejuni, and Yersinia pestis, these studies will provide fundamental insight into the long-term development of new antimicrobial compounds that will target the novel features of bCCP structure.”
Dr. Elliott, who is also a two time recipient of the Scialog® Award Research Corporation (2010-2011), and received the 2007 Gitner Award for Distinguished Teaching in 2007 and an NSF CAREER Award in 2005 (among other honors), works with the Elliott Research Group to investigate the interplay between biological systems and redox-active species (e.g., metal ions, organic radicals, disulfide bonds, reactive oxygen species). Their emphasis is on the kinetic and thermodynamic basis for catalytic redox chemistry, as well as the molecular basis of how nature tune redox cofactors do the hard work of Life.