TitleUsing Electronic Drug Monitor Feedback to Improve Adherence to Antiretroviral Therapy among HIV-Positive Patients in China
AuthorsSabin L. L., DeSilva M. B., Hamer D. H., Xu K., Zhang J., Li T., Wilson I. B., Gill C. J.
PublicationAIDS Behav. 2009 Sep; 14(3):580-9.
AbstractEffective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an adherence intervention among HIV-positive patients in southwestern China. Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining subjects were randomized to intervention/control arms. In months 7-12, intervention subjects were counseled using EDM feedback; controls continued with standard of care. Among randomized subjects, mean adherence and CD4 count were 86.8 vs. 83.8% and 297 vs. 357 cells/microl in intervention vs. control subjects, respectively. At month 12, among 64 subjects who completed the trial, mean adherence had risen significantly among intervention subjects to 96.5% but remained unchanged in controls. Mean CD4 count rose by 90 cells/microl and declined by 9 cells/microl among intervention and control subjects, respectively. EDM feedback as a counseling tool appears promising for management of HIV and other chronic diseases.
Related ProjectsChina Adherence for Life (China AFL) Study
Child and Family Applied Research Project (CFAR)