TitleProlonged Breast-feeding and Mortality up to Two Years Post-partum among HIV-positive Women in Zambia
AuthorsKuhn L., Kasonde P., Sinkala M., Kankasa C., Semrau K., Vwalika C., Tsai W. Y., Aldrovandi G. M., Thea D. M.
PublicationAIDS. 2005 Sep; 19(15):1677-81.
AbstractBACKGROUND: A previously reported association between prolonged lactation and maternal mortality has generated concern that breast-feeding may be detrimental for HIV-positive women. METHODS: As part of a trial conducted in Lusaka, Zambia, 653 HIV-positive women were randomly assigned either to a counseling program that encouraged abrupt cessation of breast-feeding at 4 months (group A) or to a program that encouraged prolonged breast-feeding for the duration of the woman's own informed choice (group B). We examined whether mortality up to 2 years post-partum increased with breast-feeding for a longer duration. RESULTS: There was no difference in mortality 12 months after delivery between 326 HIV-positive women randomly assigned to short breast-feeding [group A: 4.93%; 95% confidence interval (CI), 2.42-7.46] versus 327 women assigned to long breast-feeding (group B: 4.89%; 95% CI, 2.38-7.40). Analysis based on actual practice, rather than random assignment, also demonstrated no increased mortality due to breast-feeding. CONCLUSIONS: Although HIV-related mortality was high in this cohort of untreated HIV-positive women, prolonged lactation was not associated with increased mortality.
Related ProjectsZambia Exclusive Breastfeeding Study (ZEBS)