TitleIron Chelation as a Chemotherapeutic Strategy for Falciparum Malaria
AuthorsGordeuk V. R., Thuma P. E., Brittenham G. M., Biemba G., Zulu S., Simwanza G., Kalense P., M'Hango A., Parry D., Poltera A. A., et al.
PublicationAm J Trop Med Hyg. 1993 Feb; 48(2):193-7.
AbstractTo examine the effect of iron chelation against human malaria, 37 Zambians with asymptomatic Plasmodium falciparum infections were randomly assigned to 72-hr infusions of desferrioxamine B or placebo. Mean concentrations of ring forms decreased significantly with desferrioxamine B (P < 0.001) but not with a placebo. Over seven days of observation, mean parasite concentrations remained at the initial levels in six individuals originally given placebo, but decreased promptly with administration of desferrioxamine B (P = 0.001). Mean parasitemia was significantly lower for up to four weeks in 16 subjects treated with desferrioxamine B when compared with the eight who had received placebo only (P = 0.027). We conclude that iron chelation has antiplasmodial activity and may offer a new therapeutic strategy for falciparum malaria.