TitleHIV-specific Secretory IgA in Breast Milk of HIV-positive Mothers is not Associated with Protection Against HIV Transmission among Breast-fed Infants
AuthorsKuhn L., Trabattoni D., Kankasa C., Sinkala M., Lissoni F., Ghosh M., Aldrovandi G., Thea D., Clerici M.
PublicationJ Pediatr. 2006 Nov; 149(5):611-6.
AbstractOBJECTIVES: To test whether secretory immunoglobulin A (sIgA) to human immunodeficiency virus (HIV) antigens in breast milk of HIV-positive women is associated with protection against HIV transmission among breast-fed infants. STUDY DESIGN: Nested, case-control design in which HIV-specific sIgA was measured in breast milk collected from 90 HIV-positive women enrolled in a study in Lusaka, Zambia. Milk samples were selected to include 26 HIV-positive mothers with infected infants (transmitters) and 64 mothers with uninfected infants (nontransmitters). RESULTS: HIV-specific sIgA was detected more often in breast milk of transmitting mothers (76.9%) than in breast milk of nontransmitting mothers (46.9%, P = .009). There were no significant associations between HIV-specific sIgA in breast milk and other maternal factors, including HIV RNA quantities in breast milk, CD4 count, and plasma RNA quantities. CONCLUSIONS: HIV-specific sIgA in breast milk does not appear to be a protective factor against HIV transmission among breast-fed infants.
Related ProjectsZambia Exclusive Breastfeeding Study (ZEBS)