TitleHigh Concentrations of Interleukin 15 in Breast Milk are Associated with Protection Against Postnatal HIV Transmission
AuthorsWalter J., Ghosh M. K., Kuhn L., Semrau K., Sinkala M., Kankasa C., Thea D. M., Aldrovandi G. M.
PublicationJ Infect Dis. 2009 Oct; 200(10):1498-502.
AbstractGiven the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL-15 in breast milk may protect against postnatal HIV transmission. In a nested case-control study, we compared breast milk IL-15 levels in 22 HIV-infected women who transmitted HIV to their infants to those in 72 nontransmitters. Samples were collected in the first month of life, prior to HIV infection. IL-15 concentrations were associated with a decreased risk of HIV transmission in unadjusted analysis and after adjusting for milk viral load, CD4 cell count, and other cytokines in breast milk. IL-15-mediated immunity may protect against HIV transmission during breast-feeding.
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Related ProjectsZambia Exclusive Breastfeeding Study (ZEBS)