TitleEffects of Moderate Doses of Vitamin A as an Adjunct to the Treatment of Pneumonia in Underweight and Normal-Weight Children: A Randomized, Double-Blind, Placebo-Controlled Trial
AuthorsRodriguez A., Hamer D. H., Rivera J., Acosta M., Salgado G., Gordillo M., Cabezas M., Naranjo-Pinto C., Leguisamo J., Gomez D., Fuenmayor G., Jativa E., Guaman G., Estrella B., Sempertegui F.
PublicationAm J Clin Nutr. 2005 Nov; 82(5):1090-6.
AbstractBACKGROUND: Randomized controlled trials have shown inconsistent responses of childhood pneumonia to the use of vitamin A as an adjunct to the standard treatment of pneumonia. OBJECTIVE: We evaluated the effect of a moderate dose of vitamin A as an adjunct to standard antimicrobial treatment on the duration of respiratory signs in children with pneumonia. DESIGN: Children, aged 2-59 mo, with pneumonia and weight-for-age 12-59 mo) vitamin A or a placebo. RESULTS: Of the 287 children enrolled, 145 received vitamin A and 142 received placebo. No overall differences were observed between the 2 groups in the duration of signs of pneumonia. Multiple linear regression showed a significant interaction between basal serum retinol concentration and vitamin A group for the time (in h) to remission of respiratory signs (beta = -3.57, SE = 1.09, P = 0.001). Duration of clinical signs was less in children with basal serum retinol concentrations >200 microg/L who received vitamin A supplements than in children with similar concentrations who received placebo (69.9 +/- 49.9 h compared with 131.3 +/- 143.9 h; P = 0.049). CONCLUSIONS: Overall, we found no effect of a moderate dose of vitamin A supplementation on the duration of uncomplicated pneumonia in underweight or normal-weight children aged <5 y. However, a beneficial effect was seen in children with high basal serum retinol concentrations.
Related ProjectsApplied Research on Child Health (ARCH) Project