TitleEffect of Maternal CD4+ Cell Count, Acquired Immunodeficiency Syndrome, and Viral Load on Disease Progression in Infants with Perinatally Acquired Human Immunodeficiency Virus Type 1 Infection. New York City Perinatal HIV Transmission Collaborative Study Group
AuthorsLambert G., Thea D. M., Pliner V., Steketee R. W., Abrams E. J., Matheson P., Thomas P. A., Greenberg B., Brown T. M., Bamji M., Kalish M. L.
PublicationJ Pediatr. 1997 Jun; 130(6):890-7.
AbstractAmong a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers, we correlated infant outcome with material CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category C disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.