TitleComparison of Methods of Estimating the Mother-to-Child Transmission Rate of Human Immunodeficiency Virus Type 1 (HIV-1). New York City Perinatal HIV Transmission Collaborative Study Group
AuthorsMatheson P. B., Weedon J., Cappelli M., Abrams E. J., Shaffer N., Bamji M., Krasinski K., Lambert G., Kaul A., Grimm K., et al.
PublicationAm J Epidemiol. 1995 Oct; 142(7):714-8.
AbstractFour methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388 were born HIV-1 seropositive and 445 were HIV-1 seronegative. The four methods, the Antibody Only, Indirect, Direct, and Virologic Methods, yielded transmission rate estimates of 19-25%, classifying 59-89% of the cohort. Estimation based on persistence of HIV-1 antibody and clinical assessment yielded transmission rates similar to those methods that incorporated virologic testing.