China Adherence through Technology Study (CATS)
The CATS project is designed to increase our understanding of interventions that are feasible and effective in helping injection drug users (IDU) who are HIV-positive maintain a high ART adherence. The study will involve: (1) assessing the feasibility and acceptability of using real-time feedback; (2) using a wireless technology approach to promote ART adherence among Chinese IDU; (3) generating preliminary effectiveness data of real-time feedback on adherence, CD4 count, and HIV viral load; and (4) identifying the factors that explain how real-time feedback influences intervention success or failure.
The study will be implemented over 2.5 years through a randomized controlled trial to assess real-time feedback, an intervention that utilizes wireless technology via an electronic pill container device (‘Wisepill’), and investigating the mechanisms by which the intervention operates using quantitative and qualitative research methods. 120 IDU patients will be enrolled in a HIV clinic in Nanning, capital of Guangxi province, a border province with high rates of HIV and IDU. Enrolled patients will be randomized to intervention vs. comparison group for the 6-month intervention. The study will follow all patients for an additional 3 months to determine sustainability of intervention impact. In addition to adherence and clinical data, quantitative and qualitative data will be collected using survey instruments, focus groups, and in-depth interviews. Analysis of these data will enable achievement of the specific aims and contribute to the scientific evidence base on effective approaches to promoting ART adherence among IDU and other patients.
|Principal Investigator||Lora Sabin|
|Boston University Co-Investigators||Mary Bachman DeSilva, Allen Gifford, Christopher Gill, Taryn Vian, Wubin Xie, Bram Brooks|
|Collaborators||Zhong Li, FHI360 China|
|Dates of Research||2012-2014|
|Donor/Funder||National Institutes of Health (NIH)|