The mandate for the clinical trial team within the CGHD is to design and conduct rigorous clinical trials focused on policy-relevant topics. Historically, these studies have focused on applied research topics, asking fundamental questions such as:
- Can oral antibiotics be safely substituted for injectable antibiotics in the treatment of children with severe community-acquired pneumonia?
- What is the effect of empiric cotrimoxazole prophylaxis on Pneumococcal carriage, seroepidemiology, and antimicrobial resistance among infants who were exposed to HIV at birth?
- Are there simple tools that can be used to improve adherence to antiretroviral medications among patients with HIV?
- What are the most accurate symptoms or clusters of symptoms that identify young infants with emerging sepsis?
- Across Africa, what proportion of Streptococcus pneumoniae and Haemophilus influenzae clinical isolates are resistant to commonly used antibiotics, how does this differ by region, and how has this changed over time?
- What is the average attrition from care among African HIV patients over time?
The clinical trial team consists of clinical epidemiologists, clinicians, economists, and behavioral scientists, and its portfolio of activities includes randomized controlled trials, cohort studies, meta-analyses and systematic reviews, and statistical reviews of large linked data sets.