Donald M. Thea
Professor, Global Health
London School of Hygiene and Tropical Medicine, MSc
Columbia University, MD
- Office: Crosstown Center, CT391
- Phone: 617-414-1271
- Email: firstname.lastname@example.org
Dr. Thea received his MD from Columbia University College of Physicians and Surgeons and a Masters of Science in tropical medicine from the London School of Hygiene and trained in infectious diseases in the Department of Geographic Medicine at New England Medical Center. He has pursued a full time career in both domestic and international clinical and epidemiological infectious disease research, primarily in issues related to child survival and in particular mother to child transmission of HIV/AIDS and pneumonia. Dr. Thea was an early member of Project SIDA (Kinshasa, Zaire), the first international clinical HIV/AIDS research field site, where he did work on the etiology of diarrhea in perinatally acquired HIV infection and was the director of the Clinical Research Unit. He pursued his interest in perinatal transmission of HIV as the Principal Investigator of the New York City Collaborative Perinatal HIV Transmission Study. In 1998 he then joined the Health and Social Development Unit of the Harvard Institute for International Development where he focused on international field research in Acute Respiratory Illness, Malaria and HIV. Dr. Thea joined the Global Health department along with the other members of the Harvard team where he is currently a Professor of Global Health and the Director of the Center for Global Health and Development (CGHD). In this capacity, Dr. Thea provides senior technical leadership of a portfolio of projects addressing community treatment of neonatal sepsis, management of acute respiratory illness in children, community and facilities-based management of acute malaria, presumptive prophylaxis of malaria in pregnancy, social and behavioral aspects of HIV transmission and child sexual abuse. Dr. Thea has been the Principal Investigator of several large studies and program implementation projects including a prospective cohort study of postnatal HIV through breastmilk (the Zambia Exclusive Breastfeeding Study), the Zambia Boston University Malaria Project (ZAMBUMP), the Boston University PMTCT Integration Projects (BUPIP) – Southern Province Zambia. He is the Zambia Site PI for the Bill and Melinda funded Pneumonia Etiology Research in Child Health (PERCH) through a subcontract with Johns Hopkins University. Dr. Thea is also on the Board of Directors for the Zambian Center for Applied Health Research and Development (ZCAHRD), a local Zambian NGO organization which works closely with Boston University to implement public health research and programs.
- AIDS and the Private Sector in Africa
- Applied Diarrheal Disease Research (ADDR) Project
- Applied Research on Child Health (ARCH) Project
- Barriers to Acceptance and Adherence for ARVs in Urban Zambian Women: A Qualitative Study
- Boston University Prevention of Mother-to-Child Transmission Integration Project (BUPIP)
- Cotrimoxazole in Zambian Infants (TZI)
- External Evaluation of the Malaria Control and Evaluation Partnership in Africa (MACEPA) Project
- Hala Community Management of Pneumonia Study (HACOMP)
- Health and Development Discussion Papers
- Palliative Care and Support: Early Infant Diagnosis and Co-Trimoxazole
- Pneumonia Etiology Research for Child Health (PERCH)
- Prevention of Mother-to-Child Transmission
- Project mUbumi
- Protocol for Program Evaluation of the Antiretroviral – Antenatal Care Integration Project in Southern Zambia
- Protocol for Program Evaluation of the Rapid Syphilis Test Implementation Project in Southern Zambia
- Saving Mothers Giving Life (SMGL)
- Southern Africa Mother Infant Pertussis Study (SAMIPS)
- Supporting Healthy Exclusive Breastfeeding (SHEBA)
- Testing Oral Antibiotics Versus Injectable Antibiotics in the Treatment of Severe Pneumonia (APPIS)
- Testing Which Antibiotics Work Best for the Treatment of Very Severe Pneumonia in Infants (SPEAR)
- The Care and Treatment of Severe Pneumonia in HIV-exposed and Infected Children in Zambia
- Traditional Birth Attendants PMTCT Pilot Program (TRAP)
- Zambia Chlorhexidine Application Trial (ZamCAT)
- Zambia Exclusive Breastfeeding Study (ZEBS)
Engagement of the Community, Traditional Leaders, and Public Health System in the Design and Implementation of a Large Community-Based, Cluster-Randomized Trial of Umbilical Cord Care in Zambia
Am. J. Trop. Med. Hyg.. 2015 Feb; 92(3):666-672.
Low Rates of Treatment Failure in Children 2-59 Months Treated for Severe Pneumonia: A Multi-site Pooled Analysis
Clinical Infectious Diseases. 2013 Jan; 56(7):978-987.
Frequency and Trajectory of Abnormalities in Respiratory Rate, Temperature and Oxygen Saturation in Severe Pneumonia In Children
Pediatric Infectious Disease Journal. 2012 Aug; 31(8):863-865.
Early infant diagnosis of HIV infection in Zambia through mobile phone texting of blood test results
WHO Bulletin. 2012 May; 90(5):321-400.
Quality and safety of integrated community case management of malaria using rapid diagnostic tests and pneumonia by community health workers
Pathogens and Global Health. 2012 Mar; 106(1):32-39.
Community case management of severe pneumonia with oral amoxicillin in children aged 2–59 months in Haripur district, Pakistan: a cluster randomised tria. 2011 Nov;.
The Lancet. 2011 Nov;.
American Journal of Obstetrics & Gynecology. 2011 Jun;.
Outpatient Treatment of Children With Severe Pneumonia with Oral Amoxicillin in Four Countries: The MASS Study
Tropical Med Int Health. 2011 May;.
Community Case Management of Fever Due to Malaria and Pneumonia in Children Under Five in Zambia: A Cluster Randomized Controlled Trial
PLoS Med. 2010 Sep; 7(9).
Potential Impact of New WHO Criteria for Antiretroviral Treatment for Prevention of Mother-to-Child HIV Transmission
AIDS. 2010 Jun; 24(9):1374-7.
Int J Epidemiol. 2010 May;.
Restriction of HIV-1 Genotypes in Breast Milk does not Account for the Population Transmission Genetic Bottleneck that Occurs Following Transmission
PLoS One. 2010 Apr; 5(4):e10213.
4E10-resistant HIV-1 Isolated from Four Subjects with Rare Membrane-proximal External Region Polymorphisms
PLoS One. 2010 Mar; 5(3):e9786.
Elevations in Mortality Associated with Weaning Persist into the Second Year of Life among Uninfected Children Born to HIV-infected Mothers
Clin Infect Dis. 2010 Jan; 50(3):437-44.
HIV Prevention is Not Enough: Child Survival in the Context of Prevention of Mother to Child HIV Transmission
J Int AIDS Soc. 2009 Dec; 12(1):36.
58th Annual Meeting of the American Society of Tropical Medicine and Hygiene; 2009 Nov 1; Washington, DC.
High Concentrations of Interleukin 15 in Breast Milk are Associated with Protection Against Postnatal HIV Transmission
J Infect Dis. 2009 Oct; 200(10):1498-502.
Detection of Low Levels of Human Immunodeficiency Virus (HIV) May be Critical for Early Diagnosis of Pediatric HIV Infection by Use of Dried Blood Spots
J Clin Microbiol. 2009 Jul; 47(9):2989-91.
Growth Faltering due to Breastfeeding Cessation in Uninfected Children Born to HIV-infected Mothers in Zambia
Am J Clin Nutr. 2009 Jun; 90(2):344-53.
Differential Effects of Early Weaning for HIV-free Survival of Children Born to HIV-infected Mothers by Severity of Maternal Disease
PLoS One. 2009 Jun; 4(6):e6059.
Mortality and Virologic Outcomes After Access to Antiretroviral Therapy Among a Cohort of HIV-infected Women who Received Single-Dose nevirapine in Lusaka, Zambia
J Acquir Immune Defic Syndr. 2009 Jun; 52(1):132-6.
Pediatr Pulmonol. 2009 Mar; 44(4):379-86.
Effect of Presumptive Co-Trimoxazole Prophylaxis on Pneumococcal Colonization Rates, Seroepidemiology and Antibiotic Resistance in Zambian Infants: A Longitudinal Cohort Study
Bull World Health Organ. 2009 Jan; 86(12):929-38.
Reuse of Single-dose Nevirapine in Subsequent Pregnancies for the Prevention of Mother-to-child HIV Transmission in Lusaka, Zambia: a Cohort Study
BMC Infect Dis. 2009 Jan; 8:172.
Role of Breastfeeding Cessation in Mediating the Relationship between Maternal HIV Disease Stage and Increased Child Mortality among HIV-exposed Uninfected Children
Int J Epidemiol. 2008 Dec; 38(2):569-76.
Barriers to Acceptance and Adherence of Antiretroviral Therapy in Urban Zambian Women: A Qualitative Study
AIDS Care. 2008 Dec; 21(1):78-86.
57th Annual Meeting of the American Society of Tropical Medicine and Hygiene; 2008 Dec 1; New Orleans, LA.
Value of Chest Radiography in Predicting Treatment Response in Children Aged 3-59 Months with Severe Pneumonia
Int J Tuberc Lung Dis. 2008 Oct; 12(11):1320-6.
N Engl J Med. 2008 Jun; 359(2):130-41.
Lancet. 2008 Jun; 371(9628):1893-5.
Impact of Human Immunodeficiency Virus Infection on Streptococcus Pneumoniae Colonization and Seroepidemiology among Zambian Women
J Infect Dis. 2008 Apr; 197(7):1000-5.
Temporal and Lateral Dynamics of HIV Shedding and Elevated Sodium in Breast Milk among HIV-positive Mothers During the First 4 Months of Breast-feeding
J Acquir Immune Defic Syndr. 2008 Apr; 47(3):320-8.
Reduced Mortality Associated with Breast-feeding-acquired HIV Infection and Breast-feeding among HIV-infected Children in Zambia
J Acquir Immune Defic Syndr. 2008 Mar; 48(1):90-6.
Chloramphenicol Versus Ampicillin Plus Gentamicin for Community Acquired Very Severe Pneumonia among Children Aged 2-59 Months in Low Resource Settings: Multicentre Randomised Controlled Trial (SPEAR Study)
BMJ. 2008 Jan; 336(7635):80-4.
Ambulatory Short-Course High-Dose Oral Amoxicillin for Treatment of Severe Pneumonia in Children: A Randomised Equivalency Trial
Lancet. 2008 Jan; 371(9606):49-56.
PLoS One. 2007 Dec; 2(12):e1363.
Inferiority of Single-Dose Sulfadoxine-Pyrimethamine Intermittent Preventive Therapy for Malaria during Pregnancy among HIV-Positive Zambian Women
J Infect Dis. 2007 Nov; 196(11):1577-84.
Two-dose Versus Monthly Intermittent Preventive Treatment of Malaria with Sulfadoxine-pyrimethamine in HIV-seropositive Pregnant Zambian Women
J Infect Dis. 2007 Nov; 196(11):1585-94.
J Acquir Immune Defic Syndr. 2007 Nov; 46(5):517-8.
PLoS One. 2007 Oct; 2(10):e969.
Veterinary Field Test as Screening Tool for Mastitis and HIV-1 Viral Load in Breastmilk from HIV-Infected Zambian Women
Breastfeed Med. 2007 Oct; 2(3):172-5.
Lancet. 2007 Sep; 370(9590):824-5; author reply 826-7.
Low and Undetectable Breast Milk Interleukin-7 Concentrations are Associated with Reduced Risk of Postnatal HIV Transmission
J Acquir Immune Defic Syndr. 2007 Aug; 46(2):200-7.
Impact of HIV-1 Status on the Radiological Presentation and Clinical Outcome of Children with WHO Defined Community-acquired Severe Pneumonia
Arch Dis Child. 2007 Jun; 92(11):976-9.
Re: HIV-1 Disease Progression in Breast-feeding and Formula-feeding Mothers: a Prospective 2-year Comparison of T cell Subsets, HIV-1 RNA Levels, and Mortality
J Infect Dis. 2007 May; 195(11):1728-9; author reply 1729-30.
No Benefit of Early Cessation of Breastfeeding at 4 Months on HIV-free Survival of Infants Born to HIV-infected Mothers in Zambia: the Zambia Exclusive Breastfeeding Study. Abstract #74
14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 23; Los Angeles.
Brief Hospitalization and Pulse Oximetry for Predicting Amoxicillin Treatment Failure in Children with Severe Pneumonia
Pediatrics. 2006 Dec; 118(6):e1822-30.
HIV-specific Secretory IgA in Breast Milk of HIV-positive Mothers is not Associated with Protection Against HIV Transmission among Breast-fed Infants
J Pediatr. 2006 Nov; 149(5):611-6.
Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV-infected Women with Low CD4 Cell Counts
J Infect Dis. 2006 Nov; 194(11):1510-8.
J Nerv Ment Dis. 2006 Aug; 194(8):610-5.
AIDS. 2006 Jul; 20(11):1539-47.
Nevirapine Resistance Viral Mutations after Repeat use of Nevirapine for Prevention of Perinatal HIV Transmission
J Acquir Immune Defic Syndr. 2006 Jun; 42(2):260-2.
Trop Med Int Health. 2006 Jun; 11(6):800-3.
Failure of Standard Antimicrobial Therapy in Children Aged 3-59 Months with Mild or Asymptomatic HIV Infection and Severe Pneumonia
Bull World Health Organ. 2006 Apr; 84(4):269-75.
Cotrimoxazole Prophylaxis and Adverse Birth Outcomes among HIV-infected Women in Lusaka, Zambia. Abstract #126
13th Conference on Retroviruses and Opportunistic Infections; 2006 Feb 5; Denver.
Adherence to Zidovudine for the Prevention of Perinatal Transmission in HIV-infected Pregnant Women: the Impact of Social Network Factors, Side Effects, and Perceived Treatment Efficacy
Women Health. 2006 Jan; 42(1):99-115.
Response to Bangsberg et al., Regarding our Article ‘No Room for Complacency About Adherence to Antiretroviral Therapy in Africa’
AIDS. 2006 Jan; 20(1):141-142.
Dose Dependent Efficacy of SP for Intermittent Presumptive Therapy of Pregnancy among HIV Infected Zambian Women. Abstract 432
55th Annual Meeting of the American Society of Tropical Medicine and Hygiene; 2006 Jan 1; Atlanta, GA.
Predictors of Nonadherence to Single-dose Nevirapine Therapy for the Prevention of Mother-to-child HIV Transmission
J Acquir Immune Defic Syndr. 2005 Dec; 41(1):114-8.
Does Severity of HIV Disease in HIV-infected Mothers Affect Mortality and Morbidity Among Their Uninfected Infants?
Clin Infect Dis. 2005 Nov; 41(11):1654-61.
Treatment of Paediatric Malaria during a Period of Drug Transition to Artemether-Lumefantrine in Zambia: Cross Sectional Study
BMJ. 2005 Oct; 331(7519):734.
Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study
BMJ. 2005 Oct; 331(7519).
Prolonged Breast-feeding and Mortality up to Two Years Post-partum among HIV-positive Women in Zambia
AIDS. 2005 Sep; 19(15):1677-81.
AIDS. 2005 Jul; 19(12):1243-9.
J Acquir Immune Defic Syndr. 2005 May; 39(2):138-42.
Women in Couples Antenatal HIV Counseling and Testing are not More Likely to Report Adverse Social Events
AIDS. 2005 Apr; 19(6):603-9.
Intermittent Preventive Treatment of Malaria with Sulfadoxine-pyrimethamine in HIV Seropositive Pregnant Zambian Women. Abstract 0-7
Acta Tropica; 2005 Jan 1; Boston, MA.
Oral Amoxicillin Versus Injectable Penicillin for Severe Pneumonia in Children Aged 3 to 59 Months: a Randomised Multicentre Equivalency Study
Lancet. 2004 Sep; 364(9440):1141-8.
Challenges in the Design of Antibiotic Equivalency Studies: The Multicenter Equivalency Study of Oral Amoxicillin versus Injectable Penicillin in Children aged 3-59 Months with Severe Pneumonia
Clin Infect Dis. 2004 Sep; 39(4):526-31.
Issues in the Design of a Clinical Trial with a Behavioral Intervention — The Zambia Exclusive Breast-feeding Study
Control Clin Trials. 2004 Aug; 25(4):353-65.
AIDS. 2004 Apr; 18(2):317-24.
Journal of Business in Developing Countries. 2004 Jan; 8(1):1-38.
Questions Regarding the Effectiveness of Trimethoprim-Sulfamethoxazole (Cotrimoxazole) Prophylaxis in African Children
Clin Infect Dis. 2003 Sep; 37(6):863-4; author reply 864.
J Clin Microbiol. 2003 Jun; 41(6):2465-70.
Harv Bus Rev. 2003 Feb; 81(2):80-7, 125.
Maternal Adherence to the Zidovudine Regimen for HIV-exposed Infants to Prevent HIV Infection: a Preliminary Study
Pediatrics. 2002 Sep; 110(3):e35.
J Virol. 2002 Jul; 76(15):7365-73.
Lack of Evidence of Endogenous Avian Leukosis Virus and Endogenous Avian Retrovirus Transmission to Measles, Mumps, and Rubella Vaccine Recipients
Emerg Infect Dis. 2001 Mar; 7(1):66-72.
Early Detection of Reverse Transcriptase Activity in Plasma of Neonates Infected with HIV-1: A Comparative Analysis with RNA-based and DNA-based Testing Using Polymerase Chain Reaction
J Acquir Immune Defic Syndr. 2001 Feb; 26(1):93-102.
Evidence of Avian Leukosis Virus Subgroup E and Endogenous Avian Virus in Measles and Mumps Vaccines Derived from Chicken Cells: Investigation of Transmission to Vaccine Recipients
J Virol. 1999 Jun; 73(7):5843-51.
The Mode of Delivery and the Risk of Vertical Transmission of Human Immunodeficiency Virus Type 1–A Meta-Analysis of 15 Prospective Cohort Studies. The International Perinatal HIV Group
N Engl J Med. 1999 Apr; 340(13):977-87.
Am J Clin Nutr. 1999 Mar; 69(3):432-9.
The Evolution of HIV. Crandall K.. Baltimore, MD: Johns Hopkins University Press; 1999.
Development Discussion Paper. Boston, MA: Harvard Institute for International Development; 1999.
Distinct Risk Factors for Intrauterine and Intrapartum Human Immunodeficiency Virus Transmission and Consequences for Disease Progression in Infected Children. Perinatal AIDS Collaborative Transmission Study
J Infect Dis. 1998 Dec; 179(1):52-8.
Thymic Dysfunction and Time of Infection Predict Mortality in Human Immunodeficiency Virus-infected Infants. CDC Perinatal AIDS Collaborative Transmission Study Group
J Infect Dis. 1998 Sep; 178(3):680-5.
Sensitivity and Specificity of a Qualitative RNA Detection Assay to Diagnose HIV Infection in Young Infants. Perinatal AIDS Collaborative Transmission Study
AIDS. 1998 Sep; 12(12):1545-9.
Association of Human Immunodeficiency Virus (HIV) Load Early in Life with Disease Progression Among HIV-infected Infants. New York City Perinatal HIV Transmission Collaborative Study Group
J Infect Dis. 1998 Jul; 178(1):101-8.
Science. 1998 Jun; 280(5366):1073-7.
Incubation Period of HIV-1 in Perinatally Infected Children. New York City Perinatal HIV Transmission Collaborative Study Group
AIDS. 1998 Jun; 12(7):759-66.
Neutralizing Antibody and Perinatal Transmission of Human Immunodeficiency Virus Type 1. New York City Perinatal HIV Transmission Collaborative Study Group
AIDS Res Hum Retroviruses. 1998 May; 14(6):475-81.
Child Health Research Special Report. Cambridge, MA: Child Health Resource Consortium; 1998.
Effect of Maternal CD4+ Cell Count, Acquired Immunodeficiency Syndrome, and Viral Load on Disease Progression in Infants with Perinatally Acquired Human Immunodeficiency Virus Type 1 Infection. New York City Perinatal HIV Transmission Collaborative Study Group
J Pediatr. 1997 Jun; 130(6):890-7.
Vitamin A Deficiency and Maternal-infant Transmissions of HIV in Two Metropolitan Areas in the United States
AIDS. 1997 Mar; 11(3):325-32.
Timing of Maternal-infant HIV Transmission: Associations Between Intrapartum Factors and Early Polymerase Chain Reaction Results. New York City Perinatal HIV Transmission Collaborative Study Group
AIDS. 1997 Mar; 11(4):429-35.
Early Detection of Perinatal Human Immunodeficiency Virus (HIV) Type 1 Infection Using HIV RNA Amplification and Detection. New York City Perinatal HIV Transmission Collaborative Study
J Infect Dis. 1997 Mar; 175(3):707-11.
The Effect of Maternal Viral Load on the Risk of Perinatal Transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group
AIDS. 1997 Mar; 11(4):437-44.
Prospective Study of Human Immunodeficiency Virus 1-related Disease among 512 Infants Born to Infected Women in New York City. The New York City Perinatal HIV Transmission Collaborative Study Group
Pediatr Infect Dis J. 1996 Oct; 15(10):891-8.
Lack of Increased Risk for Perinatal Human Immunodeficiency Virus Transmission to Subsequent Children Born to Infected Women
Pediatr Infect Dis J. 1996 Oct; 15(10):886-90.
Sensitivity of HIV-1 DNA Polymerase Chain Reaction in the Neonatal Period. The New York City Perinatal HIV Transmission Collaborative Study Group
AIDS. 1996 Sep; 10(10):1181-2.
Heterosexual Behavior during Pregnancy and Perinatal Transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group
AIDS. 1996 Sep; 10(11):1249-56.
Plasma Cytokines, Cytokine Antagonists, and Disease Progression in African Women Infected with HIV-1
Ann Intern Med. 1996 Apr; 124(8):757-62.
Benefit of Primary Prophylaxis before 18 Months of Age in Reducing the Incidence of Pneumocystis Carinii Pneumonia and Early Death in a Cohort of 112 Human Immunodeficiency Virus-infected Infants. New York City Perinatal HIV Transmission Collaborative Study Group
Pediatrics. 1996 Jan; 97(1):59-64.
Comparison of Methods of Estimating the Mother-to-Child Transmission Rate of Human Immunodeficiency Virus Type 1 (HIV-1). New York City Perinatal HIV Transmission Collaborative Study Group
Am J Epidemiol. 1995 Oct; 142(7):714-8.
Neonatal Predictors of Infection Status and Early Death Among 332 Infants at Risk of HIV-1 Infection Monitored Prospectively from Birth. New York City Perinatal HIV Transmission Collaborative Study Group
Pediatrics. 1995 Sep; 96(3 Pt 1):451-8.
Efficacy of Antenatal Zidovudine in Reducing Perinatal Transmission of Human Immunodeficiency Virus Type 1. The New York City Perinatal HIV Transmission Collaborative Study Group
J Infect Dis. 1995 Aug; 172(2):353-8.
N Engl J Med. 1995 Mar; 332(13):892.
N Engl J Med. 1993 Dec; 329(23):1696-702.
Med Clin North Am. 1993 Jul; 77(4):795-814.
Trans R Soc Trop Med Hyg. 1993 May; 87(3):263-6.
Identification and Partial Purification of a Lectin on the Surface of the Sporozoite of Cryptosporidium Parvum
J Parasitol. 1992 Oct; 78(5):886-93.
Acta Paediatr Suppl. 1992 Sep; 381:45-8.
Infect Dis Clin North Am. 1989 Sep; 3(3):553-70.
Mechanisms of microbial disease. Schaechter Moselio, Medoff Gerald, Schlessinger David. Baltimore: Williams & Wilkins; 1989.
Metabolism. 1988 Dec; 37(12):1163-70.
Effective Pharmacologic Retardation of Dietary Carbohydrate Absorption without Fecal Caloric Wastage
Am J Clin Nutr. 1985 Apr; 41(4):827-835.