Lateral Flow HPV Test for Cervical Cancer Screening in Low-Resource Settings
Rebecca Richards-Kortum, Ph.D., Rice University
Cervical cancer is a leading cause of cancer death among women in the developing world. Screening programs to detect HPV, the cause of cervical cancer, have reduced the incidence and mortality of cervical cancer in the developed world. However, these screening programs are not appropriate for low-resource settings due to their high cost and need for infrastructure and trained personnel. To enable global cervical cancer prevention efforts, Kortum’s team proposes to develop an inexpensive, robust, and rapid HPV DNA test that does not require lab equipment and is as simple to use as a rapid HIV test.
The proposed work will allow the team to optimize sample preparation methods, fully characterize test performance in the lab, and assess usability of the device in a point-of-care setting. Results of this work will enable efficient identification and resolve any infield challenges before proceeding to subsequent field evaluation studies.