Welcome to the Biomolecular Systems Laboratory. The lab is organized as part of the Center for Advanced Genomic Technology (CAGT). CAGT evolved from the Molecular Engineering Research Lab, which was founded in 1990 by Dr. Charles DeLisi as a new interdisciplinary program in the Department of Biomedical Engineering within Boston University's College of Engineering.

The Biomolecular Systems Laboratory develops and applies computational/mathematical methods, and high throughput experimental methods, to analyze changes in gene and protein expression profiles of cells in response to various endogenous and exogenous signals. In collaboration with the Fraunhofer Center for Manufacturing Innovation, and the Departments of Chemistry, Physics, and Electrical Engineering, we are developing and applying new DNA and peptide microarray technologies for fingerprinting the complete molecular state of a cell. Examples include the response to ligands (drugs, toxins, hormones etc), and changes that occur as normal cells mature, differentiate, progress toward disease. The long range goal is to relate expression patterns to pathways, pathways to networks and networks to function.

Current Research
Development and application of experimental and computational methods for high throughput genomic and proteomic analysis. Computational methods for determining protein function and the topology of information processing networks Biological applications range from fundamental ( e.g. understanding how specific signals are detected, transduced, amplified, processed and stored) to applied; especially to cancer and immune reactions.

Research Flow

Code of Conduct
The Biomolecular Systems Lab follows the Code of Conduct as outlined by the Graduate School of Arts and Sciences. All students participating in the Biomolecular Systems Lab are required to be aware of the Academic Conduct Code’s contents and abide by its provisions.