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Division of Graduate Medical Sciences Bulletin

Research and Training Program in Biomolecular Pharmacology

The Training Program
Research
Faculty

Program Director David H. Farb

Program of Study

Pharmacology has historically been an interdisciplinary field, positioned at the point of convergence of physiology, biochemistry, organic chemistry, behavioral science, and medicine. The pharmacology of the next century will bring together an even wider range of disciplines, combining traditional aspects of pharmacology with novel approaches drawn from other disciplines, such as biophysics, biomedical engineering, and molecular genetics.

The predoctoral training program in Biomolecular Pharmacology is based on a training partnership among faculty in the Departments of Pharmacology, Anatomy, Biochemistry, Biophysics, Physiology, Biomedical Engineering, and the Section of Biomolecular Medicine. The curriculum formalizes interdisciplinary predoctoral training in molecular pharmacology. Students receive formal training in the principles of molecular pharmacology, as well as in molecular genetic, biophysical, and structural approaches to the study of drug-receptor interactions. A major benefit of the program is to expand opportunities for students to carry out research in these areas.

Oversight and coordination is provided by a Program Graduate Education Committee composed of faculty representatives from the participating components in the School of Medicine and the College of Engineering. The structure of the program catalyzes continued and expanded collaborations among the participating faculty, and fosters interactions among students and faculty of the participating components. This program produces scientists who have an understanding of and firsthand experience with a broad range of technologies at the cutting edge of research in molecular pharmacology.


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The Training Program

Overall Structure A major component of the training program for PhD candidates is basic research. The average tenure of PhD candidates is five years. Although the emphasis is on didactic coursework for the first year, students in the Biomolecular Pharmacology Training Program are expected to do four laboratory rotations during the first year. The laboratory rotations provide students with the opportunity to investigate potential areas for their dissertation research, while enhancing the breadth of their training. During the last three years in the program, the major emphasis is on dissertation research. Students are also required to complete advanced level coursework, report on their dissertation research, and participate in activities consistent with their development as future scientists. Details of these activities are provided below. Graduates from the program will have received essential training in pharmacology with special emphasis on molecular pharmacology. The training program builds on current graduate programs in pharmacology, biophysics, biomedical engineering, biochemistry, pathology, anatomy, and microbiology.

Students may be accepted into the program through any of the Medical School basic science departments or through the Department of Biomedical Engineering. Each of these PhD programs requires 64 credit hours for completion plus a qualifying examination, a dissertation, and a successful oral defense. Each of the programs has specific requirements, and individual programs of study for the PhD degree are determined by each student in consultation with a faculty advisor and the Program Graduate Education Committee. Students complete the following core courses: GMS BI 751 Biochemistry, GMS PM 700 Molecular Neurobiology and Pharmacology, GMS PM 710 Laboratory Techniques in Modern Pharmacology, GMS PM 800 Advanced General Pharmacology, GMS PM 810 Current Topics in Pharmacological Sciences, and 6 credits of advanced electives. The training plan has been approved by the participating departments as fulfilling their requirements. Students spend summers engaged in full-time research.

Course Requirements

Core Courses (18 credits)
GMS PM 700 Molecular Neurobiology and Pharmacology (4 cr)
GMS PM 710 Laboratory Techniques in Modern Pharmacology (2 cr) (Two semesters required in the first year; students may elect to complete additional laboratory rotations during the summer of the first year.)


GMS BI 751 Biochemistry (6 cr)
GMS PM 800 Advanced General Pharmacology (2 cr)
GMS PM 810 Current Topics in Pharmacological Sciences (2 cr)

Program electives (6 credits)
CAS CN 510 Principles and Methods of Cognitive and Neural Modeling (4 cr)
CAS MA 614 Statistical Methods II (4 cr)
ENG BE 560 Biomolecular Architecture and Design (4 cr)
ENG BE 565 Molecular Biotechnology (2 cr)
GMS BY 771 Biophysics of Macromolecular Assemblies (4 cr)
GMS MS 703 Neuroscience (4 cr)
GMS MS 753 Cell Biology (4 cr)
GMS AN 709 Neural Development and Plasticity (2 cr)
GMS PM 720 General Medical Pharmacology (8 cr)
GMS PM 820 Behavioral Pharmacology (2 cr)
GMS PM 830 Principles of Pharmacokinetics (2 cr)
GMS PM 840 Neuroendocrine Pharmacology (2 cr)
GMS PM 850 Biochemical Aspects of Neurotransmitters and Chemical Mediators (2 cr)
GMS PM 880 Gene Regulation and Pharmacology (2 cr)
GMS BI 782 Molecular Biology (4 cr)
GMS BI 783 Proteins (2 cr)
GMS BI 789 Physical Biochemistry (2 cr)
GMS BI 790 Receptors and Signal Transduction (2 cr)
GMS BY 772 Nuclear Magnetic Resonance Spectroscopy in Biology and Biochemistry (2 cr)
GMS PH 843 Cellular Physiology I (4 cr)
GMS PH 844 Cellular Physiology II (4 cr)

Seminar Courses (2 credits)
GMS BY 871, 872 Biophysics Seminar (2 cr)
GMS PM 810 Current Topics in Pharmacological Sciences (2 cr)
ENG BE 790 Biomedical Engineering Seminar


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Research

Laboratory Rotations During the first year, predoctoral trainees complete four laboratory rotations of seven weeks each. This provides exposure to a variety of experimental approaches to the study of pharmacology. Trainees are encouraged to select rotations in laboratories that approach problems from different perspectives, in keeping with the fundamental goal of providing them with a broad and more complete understanding of research strategies that have been developed to address questions of pharmacological importance. Each student submits a paper summarizing his or her research experience, which should not exceed twenty pages of double-spaced text, including bibliography. The paper is written in journal format, including abstract, introduction, methods, results, and discussion sections. Data should be summarized in figures and tables. The faculty reviews papers and provides evaluations to students.

Seminars The Biomolecular Pharmacology seminar program has been expanded recently through support provided by the endowed Sterling Drug Visiting Professorship, and an award from the Burroughs Wellcome Foundation. All students are expected to attend programmatic seminars given by highly distinguished speakers from around the world. In addition, students generally register for two semesters of Current Topics in Pharmacological Sciences. In this course, the guest lecturer attends student presentations of research paper(s) related to the lecturer's research. This course has proved to be highly successful in providing students with essential background to the seminar speaker's work and thereby preparing the students to participate actively in the department seminar. Trainees are also given a list of seminars in all participating departments and encouraged to attend those seminars relating to their area of research.

Presentation of Research Findings It is expected that trainees will present their research findings at national research meetings. Although graduate students tend to prefer the poster mode of presentation at meetings, all trainees are encouraged to give at least one slide presentation at a national meeting. They are also encouraged to present research findings at regional and local meetings, such as the Boston Area Neuroscience Group (BANG), the Boston Area Graduate Student Symposium, the New England Pharmacologists meetings, and the Boston University Graduate Student Science Day. These are yearly meetings at which there are, in addition to plenary speakers, both oral and poster presentations.

Group Meeting Presentations Both faculty and trainees meet every other month to discuss ongoing projects. At these meetings trainees give informal presentations of their current research and discuss results of recent papers from the literature. This forum also gives trainees the opportunity to discuss with faculty issues related to the training, as well as suggestions for improvement in the program.


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Faculty

Carmela R. Abraham PhD, Associate Professor of Biochemistry

Mark Alexander PhD, Assistant Professor of Pharmacology

David Atkinson PhD, Professor of Biophysics

Michael J. Baum PhD, Professor of Biology

Mark W. Bitensky MD, Research Professor of Biomedical Engineering

Norman D. Boyd PhD, Associate Professor of Pharmacology

Charles R. Cantor PhD, Professor of Biomedical Engineering (Professor of Pharmacology)

Miyoung Chun PhD, Assistant Professor of Biochemistry

Richard A. Cohen MD, Professor of Medicine (Professor of Physiology)

Charles De Lisi PhD, Professor, Department of Biomedical Engineering

Douglas V. Faller MD, PhD, Professor of Medicine

David H. Farb PhD, Professor and Chairman, Department of Pharmacology

Richard Fine PhD, Professor of Biochemistry

Terrell T. Gibbs PhD, Assistant Professor of Pharmacology

James A. Hamilton PhD, Professor of Biophysics

Tohru Ikuta MD, PhD, Assistant Professor of Pharmacology

Kevin A. Jarrell PhD, Assistant Professor of Pharmacology

Conan Kornetsky PhD, Professor of Pharmacology and Psychiatry

Susan E. Leeman PhD, Professor of Pharmacology

Simon Levy PhD, Associate Professor of Physiology

Joseph Loscalzo MD, PhD, Professor of Medicine (Professor of Biochemistry)

Isabelle M. Mintz PhD, Assistant Professor of Pharmacology

John R. Murphy PhD, Professor of Medicine

Enrico Nasi PhD, Associate Professor of Physiology

Susan P. Perrine MD, Professor of Pediatrics

R. Christopher Pierce PhD, Assistant Professor of Pharmacology

Paul F. Pilch PhD, Professor of Biochemistry

Katya Ravid DSc, PhD, Associate Professor of Biochemistry (Professor of Medicine)

Douglas Rosene PhD, Associate Professor of Anatomy and Neurobiology

Shelley J. Russek PhD, Assistant Professor of Pharmacology

G. Graham Shipley PhD, Professor of Biophysics

Elizabeth R. Simons PhD, Professor of Biochemistry

Cassandra L. Smith PhD, Professor of Biomedical Engineering (Professor of Pharmacology)

Temple F. Smith PhD, Professor of Biomedical Engineering (Professor of Pharmacology)

Kosta Steliou PhD, Professor of Chemistry (Professor of Pharmacology)

Ladislav Volicer MD, PhD, Professor of Pharmacology

Carol T. Walsh PhD, Associate Professor of Pharmacology

David J. Waxman PhD, Professor of Biology

John A. White PhD, Assistant Professor of Biomedical Engineering

Jim Z. Xiao PhD, Assistant Professor of Biochemistry

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11 March 1999
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