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Division of Graduate Medical Sciences Bulletin

Doctor of Philosophy Program in Immunology

Departmental Affiliation and General Requirements
Course Requirements
Faculty

Program Director Ann Marshak-Rothstein
617/638-4284, e-mail: itp@bu.edu

Program Codirector Jacqueline Sharon

Program Overview

The Research and Training Program in Immunology offers predoctoral candidates coursework, seminars in contemporary immunology, and research training suitable to prepare them for careers in immunology research. In addition to their required departmental and immunology coursework, students select from supplemental offerings in related disciplines. Full-time research in the laboratory of one of the training faculty is the principal mechanism to develop and enhance creative research skills for those trainees who have completed formal coursework and passed their qualifying exams. The program stresses prior research accomplishment as an important attribute in selecting candidates.

The training faculty consists of a highly interactive group of investigators with particular expertise in topics such as: B cell development and function; transcriptional regulation of macrophage and lymphocyte activity; cytokine mediated signaling pathways; factors predisposing to autoimmune disease; receptor mediated apoptosis; cancer cell biology and lymphocyte transformation; immunotherapy; HIV binding and pathogenesis; vaccine development; and airway hypersensitivity.


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Departmental Affiliation and General Requirements

Students who wish to study immunology at the Boston Medical Center are accepted for admission by one of the two participating basic science departments (Microbiology or Pathology). Each department offers a special curriculum for Immunology Training Program trainees (described below). Prospective students should select a department based on their own background and interests. More detailed information about requirements in each department may be obtained from Dr. Adrianne Rogers (pathology), Dr. Herb Kupchik (microbiology), or the program codirectors.

Students are required to undertake three laboratory rotations (2 cr each), at least two of which must be with Immunology Training Program faculty; take a qualifying examination with both written and oral components; and select a PhD thesis advisor from among the program faculty (this choice is not restricted by departmental affiliation). All students are required to participate in the Pathology or Microbiology Seminar (depend-ing on their department), the Immunology Seminar, and the Immunology Journal Club. Students in pathology without a background in histology or pathology are required to take a six-week non credit course in those subjects.


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Course Requirements

GMS Biochemistry 8 cr, to be identified based upon specific background
GMS MI 700 Concepts in Microbiology 4 cr or
GMS PA 722 Special Pathology 4 cr
GMS MI 713 Comprehensive Immunology 4 cr
GMS MI 715 Advanced Immunology--Cellular Aspects 4 cr
GMS MI 812 Microbiology Seminar 2 cr or
GMS PA 821, 822 Pathology Seminar 2 cr
GMS PA 725 Advanced Immunology--Molecular Aspects 2 cr

An additional 8 elective credits are chosen from the following list:

SPH EB 703 Intermediate Biostatistics 4 cr
GMS MS 753 Cell Biology 4 cr
GMS BI 872 Molecular Biology 4 cr
GMS BI 783 Structure and Function of Proteins 2 cr
GMS BI 776 Gene Targeting in Transgenic Mice 2 cr
GMS BI 790 Receptor and Signal Transduction 2 cr
GMS BI 823, 824 Special Topics in Pathology 2 cr
GMS BI 788 Enzyme Catalysis 2 cr
GMS BY 771 Biophysics of Macromolecular Assemblies 4 cr
GMS MI 714 Genetics of Microorganisms 4 cr
GMS MI 717 Growth Control 4 cr
GMS MI 718 Advanced Virology 4 cr
GMS MI 781 Human Genetics 4 cr
SPH EB 702 Biostatistics--Introduction to Statistical Computing 4 cr


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Faculty

David I. Beller PhD, Associate Professor of Medicine

Steven A. Bogen MD, PhD, Assistant Professor of Pathology and Laboratory Medicine

David Center MD, Professor of Medicine

Bill Cruikshank PhD, Associate Professor of Medicine

Ronald B. Corley PhD, Professor of Microbiology

Douglas V. Faller PhD, MD, Professor of Medicine

Matthew J. Fenton PhD, Associate Professor of Medicine

Douglas Golenbock MD, Associate Professor of Medicine

Dana Graves DDS, DMSc, Professor of Periodontology and Oral Biology

Shyr-Te Ju PhD, Professor of Medicine

Joseph H. Korn MD, Professor of Medicine

Hardy Kornfeld MD, Associate Professor of Pathology and Laboratory Medicine

Ann Marshak-Rothstein PhD, Professor of Microbiology

John R. Murphy PhD, Professor of Medicine

David Seldin MD, PhD, Assistant Professor of Medicine

Thomas L. Rothstein PhD, MD, Professor of Medicine

Jacqueline Sharon PhD, Professor of Pathology and Laboratory Medicine

David H. Sherr PhD, Professor of Pathology and Laboratory Medicine, Professor of Public Health (Environmental Health)

Gail E. Sonenshein PhD, Professor of Biochemistry

Gregory Viglianti PhD, Assistant Professor of Microbiology

Lee Wetzler MD, Assistant Professor of Medicine

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11 March 1999
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