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Division of Graduate Medical Sciences Bulletin

Doctor of Philosophy Program in Cell and Molecular Biology

Curriculum & Degree Requirements
Faculty

Program Director Vickery Trinkaus-Randall, PhD
Assistant Program Director Raphael A. Zoeller, PhD

The Graduate Program

The interdisciplinary Program in Cell and Molecular Biology takes advantage of the individual resources of the seven academic departments in the Division of Graduate Medical Sciences at the Boston University School of Medicine. The program focuses on basic scientific and clinical issues related to molecular and cellular biology. The participation of more than 80 faculty members offers a diversity of research opportunities and a wealth of productive interactions. Areas of expertise include molecular mechanisms regulating gene expression and developmental programs, cell structure/function relationships, molecular characterization of receptors and signal transduction processes, structural analyses of macromolecules, and the impact of health and disease on all of these areas. The availability of core facilities (i.e., FACS cell sorter, confocal microscope, microscopic imaging, transgenic mouse colony, Universitywide computer network) allows for the state-of-the-art technological approaches to address critical research issues. Students are admitted to the cell and molecular biology program and, after one year of study, enter a participating basic science department. Each student, in consultation with his or her thesis advisor and advisory committee, designs an individual program of specialized coursework built upon a core program of molecular and cellular biology. Students graduate with a PhD in a basic science department, distinguished by the phrase, "Program in Cell and Molecular Biology." Financial support is available in the form of scholarships and stipends, federally funded traineeships and fellowships, and University fellowships. There are currently over 60 students enrolled in the fields of molecular and cellular biology in the Division of Graduate Medical Sciences.

Requirements for Admission

Applicants for PhD training in molecular and cellular biology should have a bachelor's degree with emphasis in the biochemical, biological, or chemical sciences. Post-master's graduate students and MD/PhD students also qualify for admission. Students in the first year of a degree program in one of the academic departments at Boston University School of Medicine may also apply.

Programs of Study

Students entering the Program in Cell and Molecular Biology take a core curriculum during their first year of study. In addition to taking the required core courses, the students participate in three laboratory research rotations. Students do not receive academic credits for the laboratory rotations. At the end of the first year, the Cell and Molecular Biology Student Affairs Committee, in consultation with each student, negotiates placement into a basic science department whose coursework and research program suit his or her needs and interests.

Postbachelor's PhD candidates must complete 64 credits of graduate work, of which 30 to 40 credits must be in formal coursework. Post-master's PhD candidates with an MA degree in a biomedical or cell biology field and MD/PhD candidates must complete 32 credits. The number of formal course credits to be taken depends upon the academic background of each student. Students must complete a minimum of three laboratory rotations before selecting a department and a research advisor. All PhD degree students are required to submit a dissertation that demonstrates their abilities for independent study, original research, and creative scholarship. The Dissertation Advisory Committee consists of five faculty members and will represent at least two (2) departments of the Division. Please refer to the "Academic Policies and Procedures" section for details relating to programs of study.


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Curriculum & Degree Requirements

Each student participating in the Program in Cell and Molecular Biology must satisfy the course requirements and qualifying examinations established by the student's basic science department and the program. The following courses are required. All the required courses except for GMS CM 785, 786 (which will be taken during the second year) form the first-year Core Curriculum (total of 20 credits).

GMS CM 761, 762 Critical Thinking in Cell and Molecular Biology
The purpose of this course is to train students in the art of reasoning and critical thinking in the pursuit of answers to biological questions. An in-depth study of the process of refinement and reasoning which leads to the acceptance or rejection of biological models. 2 cr, 1st and 2nd sem.

GMS CM 765, 766 Mini-Courses in Cell and Molecular Biology
Two six-week mini-courses on specialized current topics in cell and molecular biology will be presented. Topics will vary from semester to semester and from year to year. Current journal articles will be read and discussed. 2 cr, 1st and 2nd sem.

Required Courses
GMS MS 753 Cell Biology 4 cr
GMS BI 751 Biochemistry 6 cr
GMS BI 782 Molecular Biology 4 cr
GMS CM 761, 762 Critical Thinking in Cell and Molecular Biology 2 cr each sem.
GMS CM 785, 786 Minicourses in Cell and Molecular Biology 2 cr

Additional requirements of the student's basic science department and the program must be completed. The second-year programs for students in each basic science department are shown below.

Projected Curricula

The following are projected curricula for second-year cell and molecular biology students, organized according to the student's basic science department:

Anatomy and Neurobiology
At least two of the courses marked (*) must be taken.

Semester 1
*GMS AN 701 Gross Anatomy 8 cr
*GMS AN 705 Microscopic Anatomy 6 cr

Semester 2
*GMS MS 703 Neuroscience 4 cr
Three courses from an approved department list (may also be taken in year 3)
A minimum of two minicourses (2 cr)
Two semesters of Anatomy Seminar (2 cr)
12 cr of research and/or electives (maximum)

Biochemistry
A minimum of three courses (8 cr) from the approved department list
A minimum of two minicourses (2 cr)
Two semesters of Biochemistry Seminar (2 cr)
20 cr of research and/or electives (maximum)

Biophysics
GMS BY 771 Macromolecular Assemblies 4 cr, 1st sem.
A minimum of two minicourses (2 cr)
Two semesters of Biophysics Seminar (4 cr)
22 cr of research and/or electives (maximum)

Microbiology
8 cr of microbiology courses from an approved department list
A minimum of two minicourses (2 cr)
Two semesters of Microbiology Seminar (2 cr)
20 cr of research and/or electives (maximum)

Pathology and Laboratory Medicine

Semester 1
GMS PA 700 Experimental Pathology 6 cr

Semester II
GMS PA 801 Special Topics in Pathology 2 cr
SPH EB 703 Biostatistics 4 cr

A minimum of two minicourses (2 cr)
Two semesters of Pathology Seminar (2 cr)
16 cr of research and/or electives (maximum)

Pharmacology and Experimental Therapeutics

Semester 1
GMS PM 810 Current Topics in Pharmacology 2 cr
Semester 2
GMS PM 700 Molecular Neurobiology 4 cr
A minimum of two minicourses (2 cr)
Two semesters of Pharmacology Seminar (2 cr)
22 cr of research and/or electives (maximum)

Physiology

Semester 1
GMS PH 542 Human Physiology 4 cr
GMS PH 741 Experimental Methods in Physiology 2 cr

Semester 2
GMS PH 543 Human Physiology 4 cr
GMS PH 742 Experimental Methods in Physiology B 2 cr
SPH EB 702 or EB 703 Biostatistics 4 cr, 1st & 2nd sem.
A minicourse (2 components) (2 cr)
Two semesters of Physiology Seminar (2 cr)
12 cr of research and/or electives (maximum)

Elective Courses

Elective courses must be chosen from the following list:

Graduate Medical Sciences
GMS MS 781 Introduction to Human Genetics 4 cr
GMS MS 783 Molecular Basis of Neurological Disease I 2 cr
GMS MS 784 Molecular Basis of Neurological Disease II 2 cr

Anatomy and Neurobiology
GMS AN 709 Neural Development and Plasticity 2 cr
GMS AN 808 Quantitative Methods for Biological Investigations 2 cr

Biochemistry
GMS BI 787 Molecular Mechanisms of Growth and Development 2 cr
GMS BI 790 Receptors and Signal Transduction 2 cr
GMS BI 783 Structure and Function of Proteins 2 cr
GMS BI 788 Enzyme Catalysis 2 cr
GMS BI 786 Biochemical Mechanisms of Aging 2 cr
GMS BI 776 Gene Targeting in Transgenic Mice 2 cr

Biophysics
GMS BY 771 Biophysics of Macromolecular Assemblies 4 cr
GMS BY 774 Metabolism and Cellular Function of Complex Lipids 2 cr

Microbiology
GMS MI 714 Genetics of Microorganisms 4 cr
GMS MI 716 Bacterial Physiology 4 cr
GMS MI 717 Growth Control and Cell Transformation 4 cr
GMS MI 718 Virology 4 cr
GMS PA 715 Advanced Immunology 2 cr

Pathology and Laboratory Medicine
GMS PA 700 Basic and Experimental Pathology 6 cr
GMS PA 725 Molecular Immunology 2 cr
GMS PA 801 Special Topics in Pathology (Transmembrane Signaling) 2 cr

Pharmacology and Experimental Therapeutics
GMS PM 700 Molecular Neurobiology and Pharmacology 4 cr
GMS PM 880 Gene Regulation and Pharmacology 2 cr

Physiology
GMS PH 742 Experimental Methods in Physiology B 2 cr
GMS PH 843 Cellular Physiology I 4 cr
GMS PH 542 Human Physiology A 4 cr
GMS PH 543 Human Physiology B 4 cr
GMS PH 741 Experimental Methods in Physiology A 2 cr

Seminar

Each student is expected to fulfill the seminar requirements of the specific basic science department in which he or she is enrolled.

Research

All students register for research credits using the research course numbers for the basic science department in which they are enrolled. The precise number of research credits depends on the student's needs and background.

Additional PhD Requirements

Information concerning qualifying examinations, the Dissertation Advisory Committee, dissertations, the final oral dissertation defense, and seminars can be found in the "Academic Policies and Procedures" section.

Degree

The basic science departments are the degree-granting entities in the Division of Graduate Medical Sciences. The degree for a student who is enrolled in the Program in Cell and Molecular Biology will read "PhD in (the appropriate basic sciences department), Program in Cell and Molecular Biology."


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Faculty

Carmela R. Abraham PhD, Associate Professor of Medicine, Associate Research Professor of Biochemistry

Karen N. Allen PhD, Assistant Professor of Physiology

Jan K. Blusztajn PhD, Associate Professor of Pathology and Laboratory Medicine and Psychiatry

Victoria Bolotina PhD, Assistant Research Professor of Physiology and Medicine

Norman D. Boyd PhD, Associate Professor of Pharmacology and Experimental Therapeutics

Peter Brecher PhD, Professor of Biochemistry and Research Professor of Biophysics and Medicine

Selwyn A. Broitman PhD, Assistant Dean for Admissions; Professor of Microbiology and Pathology and Laboratory Medicine; Professor of Nutritional Sciences, Goldman School of Dental Medicine

Stuart R. Chipkin MD, Assistant Professor of Medicine and Assistant Research Professor of Physiology

Iih-Nan (George) Chou PhD, Professor of Microbiology and Pathology and Laboratory Medicine

Miyoung Chun PhD, Assistant Professor of Biochemistry

Richard A. Cohen MD, Professor of Medicine and Associate Research Professor of Physiology

Barbara E. Corkey PhD, Associate Professor of Medicine and Associate Research Professor of Biochemistry

Ronald B. Corley PhD, Chairman and Professor of Microbiology

M. Carter Cornwall PhD, Professor of Physiology

Alvin Essig MD, Professor Emeritus of Physiology and Research Professor of Medicine

David H. Farb PhD, Chairman and Professor, Department of Pharmacology and Experimental Therapeutics

Stephen R. Farmer PhD, Professor of Biochemistry

Richard E. Fine PhD, Professor of Biochemistry and Research Professor of Neurology

Susan H. Fisher PhD, Associate Professor of Microbiology

Judith A. Foster PhD, Professor of Biochemistry

Carl Franzblau PhD, Associate Dean and Professor, Division of Graduate Medical Sciences; Chairman, Department of Biochemistry

J. Fernando Garcia-Diaz Licenciado en Ciencias, Doctor en Ciencias, Associate Professor of Physiology

Terrell T. Gibbs PhD, Assistant Professor of Pharmacology and Experimental Therapeutics

Hwai-Chen Gou PhD, Assistant Professor of Biophysics

James A. Hamilton PhD, Professor of Biophysics and Associate Research Professor of Medicine and Biochemistry

James Head PhD, Professor of Physiology

Haya Herscovitz PhD, Instructor of Biophysics

Michael Holick MD, PhD, Professor of Medicine and Physiology

Tohru Ikuta MD, PhD, Assistant Professor of Pharmacology and Experimental Therapeutics

Kevin Jarrell PhD, Assistant Professor of Pharmacology and Experimental Therapeutics

Robin Johnson PhD, Assistant Research Professor of Biochemistry

Gregor Jones PhD, Assistant Professor of Physiology

Herbert Kagan PhD, Professor of Biochemistry

Benjamin Kaminer MB, Bch, Chairman and Professor of Physiology

Konstantin Kandror PhD, Assistant Research Professor of Biochemistry

Eva Kashket PhD, Professor of Microbiology

Neil Kowall MD, Associate Professor of Neurology and Pathology and Laboratory Medicine

David M. Larson PhD, Assistant Professor of Pathology and Laboratory Medicine

William J. Lehman PhD, Professor of Physiology

Simon Levy PhD, Associate Professor of Physiology

Joseph Loscalzo MD, PhD, Director of the Whitaker Cardiovascular Institute; Professor of Medicine and Research Professor of Biochemistry

Hector Alberto Lucero LicBiochem, PhD, Assistant Professor of Physiology

C. James McKnight PhD, Assistant Professor of Biophysics

Edward F. MacNichol Jr. PhD, Professor of Physiology

Richard Mandel PhD, Associate Professor of Pathology and Laboratory Medicine and Assistant Professor of Biochemistry

Robert B. Moreland PhD, Assistant Professor of Urology and Physiology

Mary Johanna Murnane MPhil, PhD, Associate Professor of Pathology and Laboratory Medicine and Assistant Research Professor of Biochemistry

John R. Murphy PhD, Research Professor of Medicine, Microbiology, and Biochemistry

Enrico Nasi PhD, Associate Professor of Physiology

Matthew Nugent PhD, Assistant Professor of Biochemistry and Ophthalmology

Paul F. Pilch PhD, Professor of Biochemistry and Research Professor of Biophysics

Katya Ravid DSc/PhD, Assistant Professor of Biochemistry

Rahul Ray PhD, Assistant Professor of Medicine and Associate Research Professor of Physiology

Thomas L. Rothstein PhD, Associate Professor of Medicine and Assistant Professor of Microbiology

Neil B. Ruderman MD, DPhil, Professor of Medicine and Physiology

Shelley J. Russek PhD, Assistant Professor of Pharmacology and Experimental Therapeutics

Hugues J. P. Ryser MD, Professor of Pathology and Laboratory Medicine, Pharmacology and Experimental Therapeutics, and Biochemistry; Professor of Sociomedical Sciences and Community Medicine and Public Health (Environmental Health), School of Public Health

Judith Dana Saide PhD, Associate Professor of Physiology

Julie H. Sandell PhD, Assistant Professor of Anatomy and Neurobiology

Barbara Seaton PhD, Associate Professor of Physiology

Jacqueline Sharon MPhil, PhD, Professor of Pathology and Laboratory Medicine

Michael A. Shia PhD, Assistant Professor of Medicine and Assistant Research Professor of Biochemistry

Sania Shuja PhD, Assistant Professor of Pathology and Laboratory Medicine

Elizabeth R. Simons PhD, Professor of Biochemistry and Research Professor of Biophysics

Donald M. Small MD, Chairman, Department of Biophysics; Professor of Biophysics, Biochemistry, and Medicine

Barbara Smith PhD, Professor of Biochemistry

Gail E. Sonenshein PhD, Professor of Biochemistry

Raymond E. Stephens PhD, Professor of Physiology

Phillip J. Stone PhD, Professor of Biochemistry

Karen Symes PhD, Associate Professor of Biochemistry

Guillermo Taccioli PhD, Assistant Professor of Microbiology

Douglas L. Tillotson PhD, Associate Professor of Physiology

Keith Tornheim PhD, Associate Professor of Biochemistry

Paul A. Toselli MD, PhD, Associate Professor of Biochemistry

Philip C. Trackman PhD, Assistant Research Professor of Biochemistry; Assistant Professor of Periodontology and Oral Biology

Abdulmaged M. Traish PhD, Associate Professor of Biochemistry

Vickery Trinkaus-Randall PhD, Associate Professor of Ophthalmology and Associate Research Professor of Biochemistry

Robert F. Troxler PhD, Professor of Biochemistry

Gregory Viglianti PhD, Assistant Professor of Microbiology

Mary T. Walsh PhD, Assistant Professor of Biophysics and Research Instructor of Biochemistry

Glen B. Zamansky PhD, Associate Professor of Microbiology

Vassilis I. Zannis PhD, Professor of Biochemistry and Medicine

Zhi-Xiong Jim Xiao PhD, Assistant Professor of Biochemistry

Raphael A. Zoeller PhD, Associate Professor of Biophysics and Assistant Research Professor of Medicine

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11 March 1999
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