Department of Microbiology
Immunology Training Program
Courses
Faculty
Chairman Ronald B. Corley
Director of Graduate Studies Gregory A. Viglianti
Programs of Study
The Department of Microbiology of the Boston University School of Medicine offers MA and PhD degrees in microbiology as well as in interdepartmental programs in immunology and cellular and molecular biology. Students in the graduate program participate in formal coursework, seminars, and directed research in the fields of virology, bacteriology, immunology, and tumor cell biology. Participants also take courses within other basic sciences departments of the Medical School and attend seminars offered by the other universities in the Boston area.
The research interests of the faculty include: regulation of gene expression in pathogenic and sporulating bacteria, mechanisms of drug resistance in bacteria, pathogenesis and molecular biology of immunodeficiency and hepatitis viruses, regulation of humoral and cell mediated immunity, dysregulation of lymphocyte function in autoimmunity, signal transduction and gene expression in lymphocytes, eukaryotic cell growth control and carcinogenesis, and protein structure/function analysis.
Several members of the Department of Microbiology participate
with faculty in the Departments of Pathology, Biochemistry, and
Medicine in an Interdepartmental Immunology Training Grant Program.
The program consists of training both pre- and post-doctoral students.
Pre-doctoral students are prepared for a career in immunological
research and teaching through formal coursework, seminars, and
laboratory research.
Required Courses
Seminars in Ethics in Biomedical Research
Advanced Microbiology Courses
Choose eight credits of the following:
GMS MI 713 Comprehensive Immunology, 4 cr
Elective Courses
Choose eight credits of the following:
GMS BI 776 Gene Targeting in Transgenic Mice, 2 cr
Required Courses
Advanced Microbiology Courses
Choose four credits of the following:
GMS MI 714 Genetics of Microorganisms, 4 cr
Elective Courses
Choose four credits of the following:
GMS BI 776 Gene Targeting in Transgenic Mice, 2 cr
Selwyn A. Broitman PhD, Professor
Iih-Nan (George) Chou PhD, Professor
Ronald B. Corley PhD, Professor
Susan H. Fisher PhD, Associate Professor
Jianming Hu MD, PhD, Assistant Professor
Eva R. Kashket PhD, Professor
Herbert Z. Kupchik PhD, Professor
Elinor M. Levy PhD, Associate Professor
Ann Marshak-Rothstein PhD, Professor
Frederick L. Moolten PhD, Associate Professor
Guillermo E. Taccioli PhD, Assistant Professor
Gregory A. Viglianti PhD, Assistant Professor
Glen B. Zamansky PhD, Associate Professor
David I. Beller PhD, Associate Research Professor (Associate
Research Professor of Medicine)
Donald E. Craven MD, Professor (Professor of Medicine)
Caroline A. Genco PhD, Associate Professor (Associate Professor
of Medicine)
Douglas T. Golenbock MD, Assistant Professor (Assistant
Professor of Medicine)
Stuart M. Levitz MD, Professor (Professor of Medicine)
Joel Maslow MD, Assistant Professor (Assistant Professor
of Medicine)
John R. Murphy PhD, Research Professor (Research Professor
of Medicine)
Peter A. Rice MD, Professor (Professor of Medicine)
Thomas L. Rothstein MD, PhD, Professor (Professor of Medicine)
David C. Seldin MD, PhD, Assistant Professor (Assistant
Professor of Medicine)
Lee Wetzler MD, Assistant Professor (Assistant Professor
of Medicine)
Published by Trustees of Boston University
11 March 1999
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Immunology Training Program
CONVENTIONAL MICROBIOLOGY TRACK
GMS MI 700 Concepts in Microbiology, 4 cr
GMS Biochemistry,
4-8 cr, to be identified based upon specific background
GMS
MI 812 Microbiology Seminar, 2 cr
GMS MI 911, 912 Microbiology
Research, var cr
GMS MI 714 Genetics
of Microorganisms, 4 cr
GMS MI 715 Advanced Immunology, Cellular,
2 cr
GMS MI 716 Bacterial Physiology, 4 cr
GMS MI 717 Growth
Control and Cell Transformation, 4 cr
GMS MI 718 Virology,
4 cr
GMS BI 782
Molecular Biology, 4 cr
GMS BI 783 Structure and Function of
Proteins, 2 cr
GMS BI 788 Enzyme Catalysis, 2 cr
GMS BI
790 Receptor & Signal Transduction, 2 cr
GMS BY 760 Foundations
of Biophysics and Structural Biology, 6 cr
GMS BY 771 Biophysics
of Macromolecular Assemblies, 4 cr
GMS BY 774 Metabolism and
Cellular Functions of Complex Lipids, 2 cr
GMS BY 774 Lipid
Functions, 2 cr
GMS MI 814 Radiation Biology, 2 cr
GMS MS
753 Cell Biology, 4 cr
GMS MS 784 Molecular Basis of Neurological
Disease, 2 cr
GMS PA 500 Introduction to Pathology of Disease,
4 cr
GMS PA 701 Advanced Immunology & Pharmacology, 2 cr
GMS
PM 700 Molecular Neurobiology & Pharmacology, 2 cr
SPH EB 702
Biostatistics-Introduction to Statistical Computing, 2 crIMMUNOLOGY/MICROBIOLOGY TRACK
GMS MI 700 Concepts in Microbiology, 4 cr
GMS MI 713 Comprehensive
Immunology, 4 cr
GMS MI 715 Advanced Immunology, Cellular Aspects,
2 cr
GMS PA 701 Advanced Immunology, Molecular Aspects, 2 cr
GMS
Biochemistry, 4-8 cr, to be identified based upon specific background
GMS
MI 812 Microbiology Seminar, 2 cr
GMS MI 911, 912 Research
Microbiology, var cr
Seminars in Ethics in Biomedical Research
GMS MI 716 Bacterial
Physiology, 4 cr
GMS MI 717 Growth Control and Cell Transformation,
4 cr
GMS MI 718 Advanced Virology, 4 cr
GMS BI 782
Molecular Biology, 4 cr
GMS BI 783 Structure and Function of
Proteins, 2 cr
GMS BI 790 Receptor & Signal Transduction, 2
cr
GMS MS 753 Cell Biology, 4 cr
GMS MS 781 Human Genetics,
4 cr
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Courses
A
medical microbiology course that includes an introduction to bacterial
physiology and genetics and focuses on a survey of the medically
important bacteria and fungi. Includes Infectious Disease lecture
series and labs. Together with GMS MI 518 (Virology and Parasitology),
GMS MI 511 is equivalent to the Medical Microbiology course, GMS
MI 711. Kashket, staff. 4 cr, 1st sem.
Prereq:
consent of instructor. Comprehensive introduction to immunologic
principles and applications. Emphasis is placed on analysis and
interpretation of data from the primary literature. Prior coursework
in genetics and biochemistry is strongly recommended. Corley.
4 cr, 1st sem.
Prereq:
consent of instructor. The structure, replicative cycles, human
immune response, and pathogenesis of medically important viruses
and parasites are presented. Zamansky, staff. 4 cr, 2nd sem.
Prereq:
consent of instructor. This course provides a fundamental understanding
of the world of microbes and the concepts and mechanisms involved
as microbes interact/adapt in changing environments. Lectures
are taught in an interactive manner and are supplemented through
discussions and analyses of the primary literature. Viglianti.
4 cr, 1st sem.
Prereq:
consent of instructor. A medical microbiology course consisting
of a brief introduction to bacterial physiology, bacterial genetics,
and principles of immunology; a survey of medically important
bacteria, fungi, parasites, and viruses. A clinical perspective
is offered by infectious disease specialists. Kupchik. 6 cr, 1st
sem.
Prereq:
biochemistry and consent of instructor. Genetics and biochemical
methodology for studying control of gene expression. Theory of
operon and regulatory genes. Genetic transfer of chromosomal DNA
and plasmids by conjugation, transformation, and transduction.
Use of recombinant DNA technology to study gene expression. Fisher.
4 cr, 2nd sem.
Prereq:
consent of instructor. Analysis of the roles played by T and B
lymphocytes and by antigen-presenting cells, in the development
of the immune response, with emphasis on the in-class discussion
of primary research papers. Marshak-Rothstein. 2 cr, 2nd sem.
Prereq:
consent of instructor. Advanced topics discussed in a seminar
format focusing on the physiological and molecular aspects of
bacterial growth and metabolism, including energy transduction
and regulatory mechanisms. Kashket. 4 cr, 1st sem.
Prereq:
one biochemistry or cell biology course or consent of instructor.
This is a discussion-oriented course covering current topics
in: growth factors and signal transduction, oncogenes and tumor
suppressor genes, cytoskeleton, mechanisms of growth regulation,
cellular and molecular basis of transformation and the biochemistry
of transformed cells, biological response modifiers, tumorigenicity,
metastasis, and multiple drug resistance, with students leading
the discussion of selected research papers. Chou. 4 cr, 2nd sem.
Prereq:
consent of instructor. Current topics in virology are discussed.
An emphasis is placed on the molecular mechanisms by which viral
gene transcription is regulated. Zamansky, staff. 4 cr, 1st sem.
Presentation
and discussion of problems of current interest. Corley. 2 cr,
2nd sem.
Variable
cr
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Faculty
Paul H. Black MD, ProfessorJoint Faculty
Robert D. Arbeit MD, Associate Professor (Associate
Professor of Medicine)
147 Bay State Road
Boston, MA 02215
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