Category: Seminars

BME seminar: Computational Tools for the Analysis of Brain Structure, Function and Connectivity using MRI

March 26th, 2012 in Seminars

Wednesday – March 28 – 4pm

Bruce Fischl, Ph.D
Associate Professor, Harvard Medical School
Associate in Neuroscience, Massachusetts General Hospital

Computational Tools for the Analysis of Brain Structure, Function and
Connectivity using MRI

44 Cummington St, Room 203

Abstract: Magnetic Resonance Imaging technology has progressed at an astonishing rate in the last decade, with an array of new image contrasts available at higher resolution, higher SNR and/or reduced imaging time. In this talk I will discuss ongoing work at MGH with the goal of automatically extracting information from these images for the purposes of quantifying normal brain structure, function and connectivity as well as detecting departures from normal trajectories. This includes the construction and use of surface-based models of the human cerebral cortex, the modeling of major white matter fascicles from diffusion-weighted MRI, the probing of the laminar properties of the fMRI signal using models of cortical layers, and the use of ultra-high resolution ex vivo MRI to build probabilistic models of the relationship between microscopically defined boundaries and macroscopically observable geometry.

Tagged , , ,

Bravi seminar: Learning to See Late in Life

March 26th, 2012 in Seminars

Learning to See Late in Life
Mar 22, 2012 – 4pm

Learning to See Late in Life
Pawan Sinha, PhD, Brain and Cognitive Sciences, MIT

44 Cummington St, Room 203

Abstract: The hope inherent in pursuing basic research is that sometime in the future the work will prove beneficial to society. This fruition can often take many years. However, in some instances, even the conduct of basic research can yield tangible societal benefits. I shall describe an effort that perhaps fits in this category. Named ‘Project Prakash’, this initiative provides sight to blind children on the one hand and helps address several fundamental questions regarding brain plasticity and learning on the other. Through a combination of behavioral and brain-imaging studies, the effort has provided evidence of visual learning late in childhood and has illuminated some of the processes that might underlie such learning.


Bravi Seminar: Albert-László Barabási

February 10th, 2011 in Seminars

Friday – January 28, 2011 – 4:00pm

Dr. Albert-László Barabási
Network Medicine: From Complex Networks to the Human Diseasome

Center of Complex Networks Research, Northeastern University and Department of Medicine, Harvard University.

44 Cummington St. Room 203

Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine offer a platform to explore systematically not only the molecular complexity of a particular disease, leading to the identification of disease modules and pathways, but also the molecular relationships between apparently distinct (patho)phenotypes. I will review some of the tools useful to explore complex networks emerging in biology and medicine, together with the organizing principles that lie behind their effectiveness. Advances in network approaches are essential to identify new disease genes, to uncover the biological significance of disease-associated mutations identified by genome-wide association studies and full genome sequencing, and to identify drug targets and biomarkers for complex diseases.

Tagged ,