Bravi Seminar: Albert-László Barabási
Friday – January 28, 2011 – 4:00pm
Dr. Albert-László Barabási
Network Medicine: From Complex Networks to the Human Diseasome
Center of Complex Networks Research, Northeastern University and Department of Medicine, Harvard University.
44 Cummington St. Room 203
Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine offer a platform to explore systematically not only the molecular complexity of a particular disease, leading to the identification of disease modules and pathways, but also the molecular relationships between apparently distinct (patho)phenotypes. I will review some of the tools useful to explore complex networks emerging in biology and medicine, together with the organizing principles that lie behind their effectiveness. Advances in network approaches are essential to identify new disease genes, to uncover the biological significance of disease-associated mutations identified by genome-wide association studies and full genome sequencing, and to identify drug targets and biomarkers for complex diseases.