SELECTED PUBLICATIONS

 

 
2008
R. Georgescu, D. Khismatullin, R. G. Holt, J. L. Castagner, O. A'Amar and I. J. Bigio, "Design of a system to measure light scattering from individual cells excited by an acoustic wave," Opt. Expr.16(6), 3496-3503 (2008)
 
R. Reif, M. S. Amorosino, K. W. Calabro, O. A'Amar, S. K. Singh and I. J. Bigio, "Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures," J. Biomed. Opt. 13(1), 010502 (2008)
 
2007
C. S. Mulvey, A. L. Curtis, S. K. Singh and I. J. Bigio, "Elastic scattering spectroscopy as a diagnostic tool for apoptosis in cell cultures," IEEE J. of Sel. Top. in Quant. Elect. 13(6), 1663-1670 (2007)
 
R. Reif, O. A'Amar and I. J. Bigio, "Analytical model of light reflectance for the extraction of the optical properties in small volumes of turbid media," Applied Optics 46(29), 7317-7328 (2007)
 
R. Reif, M. Wang, S. Joshi, O. A'Amar and I. J. Bigio, "Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue," J. Biomed. Opt. 12(3), 034036 (2007)
 
JL Castagner and IJ Bigio, "Particle sizing with a fast polar nephelometer," Applied Optics 46: No. 4, 527-532 (2007)
 
2006
Jean-Luc Castagner and Irving J. Bigio, "Polar nephelometer based on a rotational
confocal imaging setup"
Applied Optics 45: No. 10, 2232-2239 (2006)
 
L B Lovat, K Johnson, G D Mackenzie, B R Clark, M R Novelli, S Davies, M O’Donovan, C Selvasekar, S M Thorpe, D Pickard, R Fitzgerald, T Fearn, J Bigio and SG Bown, "Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett’s oesophagus"    Gut 2006;55:1078-1083 (2006).
 
Anjan Dhar, DM, MRCP, Kristie S. Johnson, DPhil, Marco R. Novelli, PhD, FRCPath, Stephen G. Bown, MD, FRCP, Irving J. Bigio, PhD, Laurence B. Lovat, PhD, FRCP, Stuart L. Bloom, DM, FRCPPDF   "Elastic scattering spectroscopy for the diagnosis of colonic lesions:  initial results of a novel optical biopsy technique"  GASTROINTESTINAL ENDOSCOPY, Vol. 63 No. 2, 2579-261 (2006).
 
2004
IJ Bigio and SG Bown, "Spectroscopic sensing of cancer and cancer chemotherapy, current status of translational research," Cancer Biology and Therapy 3, No. 3, 259-267 (2004).
 
O A'Amar, RD Ley, IJ Bigio, "Comparison between UV-visible and NIR elastic-scattering spectroscopy of chemically induced melanomas in an animal model,"  Journal of Biomedical optics 9(6): 1320-1326 (2004).
 
KS Johnson, DW Chicken, DCO Pickard, AC Lee, G Briggs, M Falzon, IJ Bigio, MR Keshtgar, SG Bown, "Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast,"  Journal of Biomedical optics 9(6): 1122-1128 (2004).
 
O A'Amar, MS Hirsch, IJ Bigio, "Optimizing the probe geometry of elastic scattering spectroscopy for the diagnosis of prostate cancer",  Biomedical Optics conference of the Optical Society of America in Miami Beach, Florida (2004).
 
2003
IJ Bigio, O A'Amar, MS Hirsch, "Elastic scattering spectroscopy for detection of prostate cancer: preliminary feasibility study", Diagnostic Optical Spectroscopy in Biomedicine II, Proc. SPIE 5141: 142-146 (2003).
 
2002
Ousama M A’Amar and Irving J Bigio, “Correction of fluorescence spectra using data from elastic scattering spectroscopy and a modified Beer's law.” Optical Society of America Topical Meetings, Miami (2002).
 
2001
O A'Amar, R Ley, P Ripley, I Bigio, "In-vivo diagnosis of chemically induced melanoma in an animal model using UV-visible and NIR elastic-scattering spectroscopy: preliminary testing," Proc. SPIE: Biomedical Diagnostic, Guidance and Surgical-Assist Systems, Proc. SPIE 4254: 144-150 (2001).
 
2000
I. J. Bigio, S.G. Bown, G. Briggs, S. Lakhani, D. Pickard, P.M. Ripley, I.G. Rose and C. Saunders  "Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results" Journal of Biomedical Optics 5: 221-228 (2000)
 
1999
E Bossu, JJ Padilla, O A'Amar, RM Parache, D Notter, C Vigneron, F Guillemin, "Determination of endogenous porphyrins and the maximal HpD tumor/normal skin ratio in SKH-1 hairless mice by light induced fluorescence spectroscopy," Artificial Cells Blood Substitutes and Immobilization Biotechnology 27(2): 109-117 (1999).
 
Judith R. Mourant, Tamara M. Johnson, Gerrit Los, Irving J. Bigio, "Noninvasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements" Journal of Physics in Medicine and Biology 44: 1397-1417 (1999)
 
1998
H Rezzoug, L Bezdetnaya, O A'Amar, M Barberi-Heyob, JL Merlin, F. Guillemin, "Parameters affecting photodynamic activity of Foscan® or meta-tetra (hydroxyphenyl) chlorin (mTHPC) in vitro and in vivo," Lasers in Medical Science 13(2): 119-125 (1998).
 
1997
Irving J. Bigio, Judith R. Mourant  "Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy" Journal of Physics in Medicine and Biology 42: 803-814 (1997)
 
A.H. Hielscher, J.R. Mourant, I. J. Bigio, "Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions" Applied Optics 36: 125-135 (1997)
 
J. R. Mourant, T. Fuselier, J. Boyer, T. Johnson, I. J. Bigio,  "Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms" Applied Optics 36: 949-957 (1997)
 
E Bossu, O A'Amar, RM Parache, D Notter, P Labrude, C Vigneron, F Guillemin, "Determination of the maximal tumor/normal skin ratio after HpD or m-THPC administration in hairless mouse (Skh-1) by fluorescence spectroscopy, a non invasive method," Anti-Cancer Drugs 8: 67-72 (1997).
 
Judith R. Mourant, Irving J. Bigio, Darren A. Jack, Tamara M. Johnson, and Heather D. Miller,  "Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties,"   Applied Optics  36: 5655-5661 (1997).
 
1996
Judith R. Mourant, James Boyer, Andreas H. Hielscher, and Irving J. Bigio "Influence of the scattering phase function on light transport measurements in turbid media performed with small source–detector separations" Optics Letters  21: 546-548 (1996).
 
Judith R. Mourant, Irving J. Bigio, James Boyer, Tamara M. Johnson, JoAnne Lacey, Anthony G. Bohorfoush, and Mark Mellow,  "Elastic Scattering Spectroscopy as a Diagnostic Tool for Differentiating Pathologies in the Gastrointestinal Tract: Preliminary Testing", Journal of Biomedical Optics 1: 192-199 (1996).