BMERC Seminar series

Title: Occupy XLMS: Structural biology for the 99%

When: Friday , December 13th; 11:30-12:45am

Where: ERB705

Speaker:  Dr. Valdimir Svetlov (NYU)

Abstract:

Mass spectrometry-assisted mapping of covalently crosslinked peptides (XLMS) recently emerged as low-to-medium resolution method of structural analysis of proteins and their complexes. Here we present a robust workflow for XLMS analysis of bacterial transcriptional machinery and its structural bench-marking and validation. In vitro and in vivo cross-linking of proteins, computational discovery of cross-links and utilization of this information in structural proteomics will be discussed.