Tien Group

Website: people.bu.edu/jtien

Principal Investigator: Joe Tien

Research applying techniques adopted from microlithography, self-assembly, microfluidics, and developmental biology to develop methods of assembling cells into ordered three-dimensional aggregates and use these aggregates as artificial tissue and as in vitro models of disease. Current work focuses on the fabrication of branched networks such as vasculature and pulmonary trees, and spatially complex organoids such as liver acini. This laboratory is a part of the Micro and Nano Biosystems Research facilities. The Tien Group is developing new techniques to vascularize biomaterials. Current areas of interest are: the synthesis of microfluidic biomaterials (materials that contain open channels for perfusion), the quantitative physiology of engineered microvessels, and the computational design of vascular systems.