Respiratory and Physiological Systems Identification

Website: http://www.bu.edu/lungs/

Principal Investigator: Kenneth Lutchen

Development of novel linear and nonlinear systems identification approaches for probing mechanisms associated with healthy and diseased physiological systems. Principal applications in respiratory physiology. Research efforts include:

• Development of measurement, monitoring, and signal processing techniques that provide new insights on the structural airway and tissue conditions of the healthy and diseased lung
• Advanced application of mechanistic and morphometrically based models for interpreting the structure-function relations in the lung with emphasis on the mechanisms that compromise breathing capability and ventilation
• Advancing linear and nonlinear systems identification science, sensitivity analysis, and optimal experiment design to evaluate the efficacy of applying models to physiological data with emphasis on structural lung models and cardiovascular dynamics
• Understanding the origins of linear and nonlinear properties of physiological systems