Orthopaedic and Developmental Biomechanics

Principal Investigator: Elise Morgan

This laboratory uses experimental and computational methods to explore the relationships between structure, mechanical function, and biological function of tissues at multiple length scales. Principles of engineering mechanics, materials science, and cell and molecular biology are employed to investigate how the deformation and failure behavior of biological tissues depend on the tissue microstructure; and conversely, how differentiation and adaptation of tissues and cells are modulated by their local mechanical environment. Current research projects include quantification of functional loading conditions for trabecular bone, the effects of mechanical stimulation on bone and cartilage development, and the biomechanical consequences of damage in bone. The laboratory houses a complete wet lab as well as a separate computational facility for image processing and modeling.