Computational Genomics

Website: http://sites.bu.edu/phenogeno/

Principal Investigator: Simon Kasif

The research we pursue in partnership with major genomic centers and several other laboratories involves the development of new biotechnology and computational frameworks for the analysis, computational representation, measurement and modeling of biological systems. We are interested in human cells (e.g. insulin signaling networks) as well as bacterial genomics. 1) Computational Functional Genomics: new gene identification, functional classification and gene expression analysis. 2) Computational comparative genomics: methods for comparing complete genomic sequences at different levels of detail. 3) Discovery and modeling of biological pathways using probabilistic networks. 4) Genomic Biotechnology: new computer-assisted genomic and proteomic technologies. 5) Clinical Research focusing on Diabetes and Cancer.