Engineering a Robust Fully Automated, Closed-loop Control Unit for Glucose Regulation in Type 1 Diabetes

Edward Damiano, Ph.D.
Associate Professor – Biomedical Eng
Boston University – Engineering
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Steven J. Russell, M.D., Ph.D.
Massachusetts General Hospital
Harvard Medical School – Instructor of Medicine
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Artificial Pancreas Website

OBJECTIVE: To develop a closed-loop system that enables automated tight glycemic control by integrating glucose sensor data with drug infusion pump technology through a novel control algorithm.

The development of this drug delivery device that responds to glucose concentrations to automatically avoid both high and low blood glucose, a so-called artificial endocrine pancrease, has been a long-term goal of diabetes therapy.  Although it is well known that people with diabetes do not make enough insulin, it is also true that their pancreas does not release glucagon, a blood-raising hormone, in response to hypoglycemia.  Previous artificial pancreas designs did not include the capability to administer glucagon.

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