Polysaccharide Surrogates for the Treatment of Osteoarthritis

photo of Dr. GrinstaffMark Grinstaff, Ph.D.
Professor – Biomedical Engineering
Professor – Chemistry
Boston University – College of Engineering

briansnyderBrian Snyder, M.D., Ph.D.
Associate Professor – Orthopaedic Surgery
Harvard Medical School – School of Medicine
Children’s Hospital Boston – Orthopaedic Surgery

OBJECTIVE: To synthesize and evaluate a novel, longer lasting “bio-lubricant” of polysaccharide surrogate polymers for the treatment of arthritic and sport-injured joints.  The current treatment procedure for arthritic and sports-injured knee joints involves repeated injections of of hyaluronic acid (HA) affording sub-optimal patient outcomes likely due to short resident time.

injection

human_knee..flex

Center for Nanoscience and Nanobiotechnology