Multiplexed, Rapid, Point of Care Device to Quantify Allergen-Specific IgE
M. Selim Ünlü, Ph.D.
Professor – Biomedical Engineering
Professor – Electrical and Computer Engineering
Frédéric Little, M.D.
Assistant Professor – Pulmonary Medicine
Boston University School of Medicine
OBJECTIVE: To develop a tabletop sensor that more specifically and rapidly determines allergic sensitization to food and airborne allergen triggers via quantification of allergen-specific IgE.
The team is assembling a portable prototype of the CaFE platform, developing chemistries and optimal conditions for detection of allergen-specific IgE on that platform, and focusing proof of concept for platform accuracy and function on 12 clinically relevant allergens. The results from CaFE will then be compared with the in vitro industry standard in the US (Phadia ImmunoCAP) on sera from recruited subjects as well as from sera of asthmatics. This work will be in preparation for a proposed clinical pilot study.