Funded Projects 2012 – 2013

FNA Tools for ESS: Clinical Application to Thyroid Cancer (Renewed)
Bigio, Irving Ph.D., Rosen, Jennifer M.D., and Lee, Stephanie M.D.
Business: Diagnostic

Dr. Bigio, Dr. Rosen, and Dr. Lee are developing and clinically testing a disposable tool that integrates an ESS fiberoptic probe into an FNA needle to be used in patients with thyroid nodules. The improved diagnostic accuracy, compared to FNA/cytology alone, will significantly reduce the number of unnecessary surgical thyroidectomies, reducing the incidence of patient morbidity and enabling significant cost savings for the healthcare system.

Point-of-care diagnostic chip for rapid antibiotic susceptibility testing using reactive oxygen species (ROS) in the clinical setting
Khalil, Ahmad, S. Ph.D. Collins, James J. Ph.D. Klempner, Mark S. Ph.D. Green-Hopkins, Isreal, M.D.
Business: Diagnostic

Dr. Khalil, Dr. Collins, Dr. Klempner, and Dr. Green-Hopkins are developing a point-of-care diagnostic to rapidly identify antibiotic susceptibility will allow for faster, more targeted therapies to combat bacterial infections, thus reducing reliance on empiric therapy and minimizing healthcare burden associated with delayed therapy, antibiotic overuse, and medication adverse events.

Cellphone-based microscopy for blood smear screening and malaria detection
Mertz, Jerome C Ph.D. Gill, Christopher, M.D.
Business: Medical Device

Dr. Mertz and Dr. Gill are developing a simple add-on that enables a standard optical microscope to simultaneously quantify both phase and amplitude in an image (standard microscopes quantify only amplitude), so as to produce highly detailed 3D morphological images. This technology will initially be developed to improve blood smear analyses for malaria detection in resource limited settings.

Compound Multimodality Breast Biopsy Clip (Renewed)
Nicolas Bloch, M.D. and Mark Grinstaff, Ph.D.
Business: Medical Device

Dr. Grinstaff and Dr. Bloch are developing a breast biopsy marker or clip that is comprised of materials that can be readily seen on all imaging modalities (ultrasound, mammogram, MRI). The novel design will enable fast deployment through a needle track along with tissue integration to prevent migration from the site and will significantly improve diagnosis capabilities and treatment regimens for breast cancer patients.

PharmaCheck: Counterfeit and Substandard Drug Detector Device for the Developing World (Renewed)
Zaman, Muhammad, Hamid, Ph.D. Gill, Christopher, M.D.
Business: Medical Device

Dr. Zaman and Dr. Gill are developing an improved, easy-to-use, and cost-effective technology (PharmaCheck) for screening prescription medicines in order to prevent poor treatment of life-threatening illnesses and protect against counterfeit and substandard medicines in resource-limited countries.

Testing Variable Ventilation in human patients with respiratory failure
Suki, Bela, Ph.D. O’Connor, George, T. M.D.
Business: Medical Device

Dr. Suki and Dr. O’Connor are developing and performing human testing of a novel mechanical ventilation strategy, called Variable Ventilation, which improves lung physiology, overall patient condition and minimizes the risk of further injury for patients requiring mechanical ventilation in the ICU.

Constant Therapy: A tablet therapy platform for speech language therapy for individuals with brain damage
Stepp, Cara, Ph.D. Kiran, Swathi, Ph.D.
Business: Healthcare IT

Dr. Stepp and Dr. Kiran are developing Constant Therapy, an online health system that provides ongoing rehabilitation services to patients via iPads, iPhones and the Web. Constant Therapy rehabilitation services currently focus on patients with communication disorders (Speech, Language and Hearing), and can potentially be expanded in the future to patients needing Physical and Occupational therapy.

Implantable Inhibitors of Cancer Metastasis
Grinstaff, Mark W. Ph.D. Sherr, David H. Ph.D.
Business: Pharmaceutical

Dr. Grinstaff and Dr. Sherr are testing an implantable device which, over time, saturates the local microenvironment of breast cancers with potent, novel, non-toxic therapeutics (“AhR modulators”) that specifically block tumor metastasis and cancer stem cell growth. The product is expected to address a critical unmet need for patients with “triple negative” breast cancers and for breast cancer patients who have failed conventional or other targeted therapeutics.

The Prevention of Intraabdominal Adhesion Formation and Reformation Using Drug-Containing Liposomes
Stucchi, Arthur, M.D. Wong, Joyce Ph.D. Burke, Peter, M.D. Agarwal, Suresh, M.D.
Business: Pharmaceutical

Dr. Stucchi, Dr. Wong, Dr. Burke, and Dr. Agarwal are developing a highly effective drug-containing lipid-coated microbubble to prevent the formation and reformation of abdominal adhesions. The use of this product in patients undergoing abdominopelvic surgery could drastically reduce postoperative morbidity and overall healthcare costs.