Funded Projects 2011 – 2012

FNA Tools for ESS: Clinical Application to Thyroid Cancer (Renewed)
Bigio, Irving Ph.D., Rosen, Jennifer M.D., and Lee, Stephanie M.D.
Business: Diagnostic

Dr. Bigio, Dr. Rosen, and Dr. Lee are developing and clinically testing a disposable tool that integrates an ESS fiberoptic probe into an FNA needle to be used in patients with thyroid nodules. The improved diagnostic accuracy, compared to FNA/cytology alone, will significantly reduce the number of unnecessary surgical thyroidectomies, reducing the incidence of patient morbidity and enabling significant cost savings for the healthcare system.

Multiplexed, Compact, Point of Care Device to Quantify Specific IgE to Common Allergens (Renewed)
Selim, Unlu, Ph.D. and Frederic, Little, M.D.
Business: Diagnostic

Dr. Selim and Dr. Frederic are developing a tabletop sensor that more specifically and rapidly determines allergic sensitization to food and airborne allergen triggers via quantification of allergen-specific IgE.

PharmaCheck: Counterfeit and Substandard Drug Detector Device for the Developing World
Zaman, Muhammad, Hamid, Ph.D. Gill, Christopher, M.D.
Business: Medical Device

Dr. Zaman and Dr. Gil are developing an improved, easy-to-use, and cost-effective technology (PharmaCheck) for screening prescription medicines in order to prevent poor treatment of life-threatening illnesses and protect against counterfeit and substandard medicines in resource-limited countries.

Compound Multimodality Breast Biopsy Clip
Nicolas Bloch, M.D. and Mark Grinstaff, Ph.D.
Business: Medical Device

Dr. Grinstaff and Dr. Bloch are developing a breast biopsy marker or clip that is comprised of materials that can be readily seen on all imaging modalities (ultrasound, mammogram, MRI). The novel design will enable fast deployment through a needle track along with tissue integration to prevent migration from the site and will significantly improve diagnosis capabilities and treatment regimens for breast cancer patients.

Subcutaneous Continuous Glucose Monitoring and Intravenous Dosing of Insulin and Dextrose for Automated Glycemic Control in the Inpatient Setting (Renewed)
Edward Damiano, Ph.D./  Steven Russell, M.D. Ph.D.
Business: Medical Device

Dr. Damiano and Dr. Russell are managing the first-in-humans trial of a fully integrated, automated, closed-loop blood glucose control system designed for inpatient use. This system will utilize the signal from a minimally invasive continuous glucose monitor every 5 minutes to inform an algorithm that will, in turn, automatically regulate intravenous infusions of insulin and dextrose to tightly regulate blood glucose (BG).

Improving Health Choices with Wireless Devices
Imler, Dan, M.D. Mountain, David, Ph.D.
Business: Healthcare IT

Dr. Imler and Dr. Mountain are developing a novel software platform connecting real world health actions (activity, nutrition, medication compliance, etc.) to gaming applications where intrinsic mechanics can influence young patients’ motivation to make healthier decisions.

Targeting IgE-mediated Diseases
Ganley-Leal, Lisa Ph.D. Wong, Joyce Ph.D. Connor, John, Ph.D.
Business: Pharmaceutical

Dr. Ganley-Leal, Dr. Wong, and Dr. Connor are developing an effective allergy treatment with reduced side effects would mitigate the impact of disease for the 75 million Americans suffering from chronic allergies, particularly in children who suffer the greatest from sleep disturbances, increased co-morbidities and side effects from current medications.