Cycle VI Projects: 2011-2012

  • Targeting IgE-mediated Diseases

Lisa Ganley-Leal, Ph.D., Joyce Wong, Ph.D., John Connor, Ph.D.

Development of an effective allergy treatment with reduced side effects would mitigate the impact of disease for the 75 million Americans suffering from chronic allergies, particularly in children who suffer the greatest from sleep disturbances, increased co-morbidities and side effects from current medications.

  • Improving Health Choices with Wireless Devices

Dan Imler, M.D., and David Mountain, Ph.D.

A novel software platform connecting real world health actions (activity, nutrition, medication compliance, etc.) to gaming applications where intrinsic mechanics can influence a child’s motivation to make healthier decisions.

  • PharmaCheck: Robust, High-throughput Microfluidic Platform for Rapid Testing of Counterfeit and Substandard Drugs

Muhammad Zaman, Ph.D. and Christopher Gill, M.D.

An improved, easy-to-use, and cost-effective technology (PharmaCheck) for screening prescription medicines in order to prevent poor treatment of life-threatening illnesses and protect against counterfeit and substandard medicines in resource-limited countries.

  • Compound Multimodality Breast Biopsy Clip

Nicolas Bloch, M.D. and Mark Grinstaff, Ph.D.

A breast biopsy marker or clip that is comprised of materials that can be readily seen on all imaging modalities (ultrasound, mammogram, MRI).

  • Multiplexed, Compact, Point of Care Device to Quantify Specific IgE to Common Allergens (continuation project)

M. Selim Unlu, Ph.D. and Frederic Little, M.D.

A tabletop sensor that more specifically and rapidly determines allergic sensitization to food and airborne allergen triggers via quantification of allergen-specific IgE.

  • FNA Tools for ESS:  Clinical Application to Thyroid Cancer (continuation project)

Irving Bigio, Ph.D., Jennifer Rosen, M.D., and Stephanie Lee, M.D.

Develop and clinically test a disposable tool that integrates an ESS fiberoptic probe into an FNA needle to be used in patients with thyroid nodules. The improved diagnostic accuracy, compared to FNA/cytology alone, will significantly reduce the number of unnecessary surgical thyroidectomies, reducing the incidence of patient morbidity and enabling significant cost savings for the healthcare system.

  • Subcutaneous Continuous Glucose Monitoring and Intravenous Dosing of Insulin and Dextrose for Automated Glycemic Control in the Inpatient Setting (continuation project)

Ed Damiano, Ph.D. and Steven J. Russell, M.D.

First-in-humans trial of a fully integrated, automated, closed-loop blood glucose control system designed for inpatient use. This system will utilize the signal from a minimally invasive continuous glucose monitor every 5 minutes to inform an algorithm that will, in turn, automatically regulate intravenous infusions of insulin and dextrose to tightly regulate blood glucose (BG). The system is entirely reactive, with its only input being the weight of the subject at initialization and frequent interstitial fluid glucose measurements.