Muhammad Zaman, Ph.D.
Professor, Biomedical Engineering
Professor, Howard Hughes Medical Institute
Ph.D, Chemistry – University of Chicago, 2003
Phone: (617) 358-5881
Fax: (617) 353-6766
Office: 36 Cummington St, Room 315
Systems Biology of Cancer, Cell Adhesion and Migration in 3D environments, Cellular Mechanics, Applications of BME in the developing world.
Research in our lab is focused at the interface of cell biology, mechanics, systems biology and medicine. We are interested in understanding and decoupling the integrated chemical, biological and mechanical basis of tumor invasion that precedes metastasis. We utilize computational and experimental tools rooted in cell biology, chemistry, mechanics and imaging to ask how cells process external information and use it to develop specific responses in native like 3D environments. Our work is also aimed at developing multi-scale models, integrating both first principle and data driven approaches to quantify cell signaling, adhesion and motion in 3D environments.
The second main thrust of our research is focused on developing computational and experimental tools to improve the quality of life, education and the practice of medicine in the developing world. In this regard, we are working closely with the Center for Global Health and various medical schools and engineering institutions around the globe to develop cheap, robust and easy to use solutions to develop improved diagnostics and tools for data analysis.
Selected Recent Publications
(For a complete list, see the Zaman Lab website)
Erin L. Baker, Roger T. Bonnecaze and Muhammad H. Zaman. Multiple Particle-Tracking Microrheology Reveals that Extracellular Matrix Stiffness and Architecture Govern Intracellular Viscoelasticity. Biophysical Journal. 97 (4) 1013-21. 2009.
Mark Kness, Ge Wang and Muhammad H. Zaman. Robustness of Integrin Signaling Network. Journal of Chemical Physics. 130 (23) 235103. 2009.
Tianyi Yang and Muhammad H. Zaman. Cell Adhesion to Nano Ligands: Effects of Ligand Size and Concentration in Solution. Langmuir, 24 (20), 1181911827, 2008.
Heiko Enderling, Nelson Alexander, Emily Clark, Lourdes Estrada, Cornelia Crooke, Jerome Jourquin, Nichole Lobdell, Muhammad H. Zaman, Alexander R.A. Anderson, and Alissa Weaver. A Cellular Automaton Model of Invadopodia-ECM Interactions. Biophysical Journal. 95(5):2203-18. 2008.
Tianyi Yang and Muhammad H. Zaman. Thermodynamics of Clustered and Unclustered Systems in Cell Adhesion. Chemical Physics Letters. 454.362-366. 2008.