Research Interests

Synthetic and systems biology in immune cells.

Current Research

We are interested in applying metabolic engineering and immune cell engineering to rapidly and predictably engineer desired properties in human immune cells to treat diseases.

Selected Recent Publications

Wong, W.W*.,Wei, P*., Park, J.S., Corcoran, E. E., Peisajovich, S. G., Onuffer, J, J., Weiss, A., Lim, W.A. “Using Bacterial Effector Proteins as Tools to Rewire MAPK Signaling in Yeast and Immune Cells” (*co-first author, under revision)

Wong, W.W., Liu, L., Corcoran, E. E., Weiss, A., Lim, W.A. “Reshaping T-cell signaling dynamic through synthetic feedback loops” (In Preparation)

Wong, W.W., Liao, J.C. “Microbial maximal specific growth rate as a square-root function of biomass yield and two kinetic parameters” Metabolic Engineering. 11(6): 409-14. (2009)

Wong, W.W., Tran, L.M., Liao, J.C. “A hidden square-root boundary between growth rate and biomass yield” Biotechnology and Bioengineering. 1(102): 73-80. (2009)

Wong, W.W., Tsai T.Y., Liao, J.C. “Single-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator” Molecular Systems Biology. 3(130): 1-8. (2007)

Xie, X., Wong, W.W., Tang, Y. “Improving simvastatin bioconversion in Escherichia coli by deletion of bioH” Metabolic Engineering. 9(4): 379-386. (2007)

Wong, W.W., Liao, J.C. “The Synthetic Approach for Regulatory Circuits and Metabolism” Systems Biology and Synthetic Biology. John Wiley & Sons, Chapter 14. (2009)

Wong, W.W., Liao, J.C. “A Synthetic Approach to Transcriptional Regulatory Engineering” The Metabolic Pathway Engineering Handbook: Fundamentals. CRC Press. (2009)

Wong, W.W., Liao, J.C. “The design of intracellular oscillators that interact with metabolism” Cellular and Molecular Life Science. 63(11): 1215-1220. (2006)

Brynildsen, M.P., Wong, W.W., Liao, J.C. “Transcriptional regulation and metabolism” Biochemical Society Transactions. 33(6): 1423-1426. (2005)

Fung, E., Wong, W.W., Suen, J.K., Bulter, T., Lee, S., Liao, J.C. “A synthetic gene-metabolic oscillator” Nature. 435(5): 118-122. (2005)

Bulter, T., Lee, S., Wong, W.W., Fung, E., Connor, M. and Liao, J.C. “Design of artificial cell-cell communication for gene and metabolic circuits” Proceedings of the National Academy of Science, USA. 101(8): 2299-2304. (2004)

Highlighted in Commentary: Gerchman Y, and Weiss R. Teaching bacteria a new language. Proceedings of the National Academy of Science, USA. 101(8): 2221-2222.

Wong, W.W., and Newman, J.S. “Monte Carlo Simulation of the Open-Circuit Potential and the Entropy of Reaction in Lithium Manganese Oxide” Journal of the Electrochemical Society. 149(4): A493-A498. (2002)

Wang, J., Chun, H.J., Wong, W.W., Spencer, D.M., and Lenardo, M.J. “Caspase-10 is an initiator caspase in death receptor signaling” Proceedings of the National Academy of Science, USA. 98(24): 13884-13888. (2001)