Bela Suki, Ph.D.
Professor, Biomedical Engineering
Mechanical properties of living tissues; Mechanotransduction; The ensemble behavior of complex biological systems; Nonlinearities in biological systems.
Dr. Suki’s current research involves evaluating the effects of variability in mechanical stretch on cell function. Specifically, mechanotransduction in the laboratory is always studied using sinusoidal stretching. However, in the body, cells are never exposed to strictly monotonous mechanical perturbations. Variability itself appears to influence essential cell functions such as ATP production. His other fields of interest is the coupling between enzyme activity and mechanical forces in the extracellular matrix as well as applying statistical mechanical concepts to large biological networks.
Selected Recent Publications
Suki, B., J.H.T. Bates, U. Frey. “Complexity and emergent phenomena” Comprehensive Physiology, The Respiratory System, Respiration Mechanics: Organ, Cell Molecule, Vol. 1, eds. Fredberg J. J., Sieck ,G. C., Gerthoffer, W. T., Wiley-Blackwell. pp. 995–1029. (2011)
Parameswaran, H., Majumdar, A., Suki, B. “Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3d computational model” Plos Comp. Biol. 7(4): e1001125. (2011)
Araújo, A., Majumdar, A., Parameswaran, H., Yi, E., Spencer, J., Nugent, M., and Suki, B. “Dynamics of enzymatic digestion of elastic fibers and networks under tension” Proc. Natl. Acad. Sci. 108(23): 9414-9419. (2011)
Hamakawa, H, E Bartolák-Suki, H Parameswaran, A Majumdar, KR Lutchen and Suki, B. “Structure-function relations in an elastase-induced mouse model of emphysema” Am. J. Respir. Cell Mol. Biol. 45: 517-524. (2011)
Jesudason, R, S Sato, H Parameswaran, AD Araujo, A Majumdar, PG Allen, E Bartolák-Suki and B. Suki. “Mechanical forces regulate elastase activity and binding site availability in lung elastin” Biophys J. 99(9): 3076-3083. (2010)
Arold, S.P., E. Bartolák-Suki and B. Suki. “Variable stretch pattern enhances surfactant secretion in alveolar type II cells in culture” Am. J. Physiol.: Lung Cell Mol Physiol. 296(4): L574-581. (2009)
Ritter, M.C., R. Jesudason, A. Majumdar, D. Stamenović, J.A. Buczek-Thomas, P.J. Stone, M.A. Nugent, and B. Suki. “A zipper network model of the failure mechanics of extracellular matrices” Proc. Natl. Acad. Sci. 106: 1181-1186. (2009)
Frey, U., and B. Suki. “Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control” The Lancet. 372 (9643): 1088-1099. (2008)
Suki, B., A Majumdar, MA Nugent, JHT Bates. “In silico modeling of interstitial lung mechanics: implications for disease development and repair” Drug Discovery Today: Disease Models. 4 (3): 139-145. (2007)
Frey, U., T. Brodbeck, A. Majumdar, D.R. Taylor, G.I. Town, M. Silverman and B. Suki. “Risk of severe asthma episodes predicted from fluctuation analysis of airway function” Nature. 438: 667-670. (2005)