Mark W. Grinstaff, Ph.D.

Professor, Biomedical Engineering
Professor, Chemistry

Center for Nanoscience and Nanobiotechnology

Ph.D., University of Illinois at Urbana-Champaign
A.B., Chemistry Honors, Occidental College
Curriculum Vitae

Email: mgrin@bu.edu
Website: people.bu.edu/mgrin/
Office: SCI 518
Office hours: By appointment

Research Interests

Biomaterials, tissue engineering, drug delivery, macromolecular chemistry and engineering, self-assembly, nanodevices.

Current Research

My group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of our current research projects, we are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, we are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, we are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, we are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Selected Recent Publications

Full List of Publications

Xin Huang, Stefan Zauscher, Bruce Klitzman, George A. Truskey, William M. Reichert, Daniel J. Kenan, and Mark W. Grinstaff “Peptide Interfacial Biomaterials Improve Endothelial Cell Adhesion and Spreading on Synthetic Polyglycolic Acid Materials” Annals of Biomedical Engineering. 38, 1965-1976. (2010)

Rong Liu, Jesse B. Wolinsky, Joseph Walpole, Emily Southard, Lucian R. Chirieac, Mark W. Grinstaff, and Yolonda L. Colson “Prevention of Local Tumor Recurrence Following Surgery Using Low-Dose Chemotherapeutic Polymer Films” Annals of Surgical Oncology. 17, 1203-1213. (2010)

Neel S. Joshi, Prashant N. Bansal, Rachel C. Stewart, Brian D. Snyder, and Mark W. Grinstaff “The Effect of Contrast Agent Charge on Visualization of Articular Cartilage Using Computed Tomography: Exploiting Electrostatic Interactions for Improved Sensitivity” Journal of the American Chemical Society. 131, 13234-13235. (2009)

Xiaojuan Khoo, Paul Hamilton, George A. O’Toole, Brian D. Snyder, Daniel J. Kenan, and Mark W. Grinstaff “Directed Assembly of PEGylated-Peptides for Infection-resistant Titanium Implant Coatings” Journal of the American Chemical Society. 131, 10992-10997. (2009)

Aaron P. Griset, Joseph Walpole, Rong Liu, Ann Gaffey, Yolonda L. Colson, and Mark W. Grinstaff “Expansile Nanoparticles: Synthesis, Characterization, and In vivo Efficacy of an Acid-Responsive Polymeric Drug Delivery System” Journal of the American Chemical Society. 131, 2469-2471. (2009)

Claire Ceballos, Carla A.H. Prata, Suzanne Giorgio, Frédéric Garzino, Dominique Payet, Philippe Barthélémy, Mark W. Grinstaff, and Michel Camplo “Cationic Nucleoside Lipids Based on a 3-Nitropyrrole Universal Base for siRNA Delivery” Bioconjugate Chemistry. 20, 193–196. (2009)

John P. Berdahl, C. Stark Johnson, Alan D. Proia, Mark W. Grinstaff, and Terry Kim “Comparison of Sutures and New Dendritic Polymer Adhesives for Corneal Laceration Repair in an In Vivo Chicken Model” Archives of Ophthalmology. 127, 442-447. (2009)

William C. Ray III, Mark W. Grinstaff “Polycarbonate and Polycarbonate-esters Synthesized from Biocompatible Building Blocks of Glycerol and Lactic Acid” Macromolecules. 36: 3557-3562. (2003)

Daijiro Miki, Anne Pfister-Serres, Kourosh A. Dastghieb, Kimberly A. Smeds, Makoto Inoue, Diane L. Hatchell, Mark W. Grinstaff “A Photopolymerized Sealant for Corneal Lacerations” Cornea. 21: 393-399. (2002)

Michael A. Carnahan, Crystan Middleton, Jitek Kim, Terry Kim, Mark W. Grinstaff “Hybrid Dendritic-Linear Polyester-ethers for In Situ Photopolymerization” J. Am. Chem. Soc. 124: 5291-5293. (2002)

Geoffrey S. Hird, Thomas J. McIntosh, Anthony A. Ribeiro, Mark W. Grinstaff “Synthesis and Characterization of Carbohydrate-Based Phospholipids” J. Am. Chem. Soc. 124: 5983-5992. (2002)

Mark W. Grinstaff “Biodendrimers: New Polymeric Biomaterials for Tissue Engineering” Chem. Eur. J. 8: 2838-2846. (2002)